Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Aaron J. Oakley"'
Autor:
Zhi-Qiang Xu, Slobodan Jergic, Allen T. Y. Lo, Alok C. Pradhan, Simon H. J. Brown, James C. Bouwer, Harshad Ghodke, Peter J. Lewis, Gökhan Tolun, Aaron J. Oakley, Nicholas E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader complexes (CLCs). Detailed understanding of the mechanisms by which CLCs open and place
Externí odkaz:
https://doaj.org/article/9e8880c9aa2c40dbb2212545d9c48737
Autor:
Aaron J. Oakley
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1240 (2023)
With the development of accurate protein structure prediction algorithms, artificial intelligence (AI) has emerged as a powerful tool in the field of structural biology. AI-based algorithms have been used to analyze large amounts of protein sequence
Externí odkaz:
https://doaj.org/article/a889c1b2f1fe4d9b9c516e11400045d6
Autor:
Timothy P. Newing, Aaron J. Oakley, Michael Miller, Catherine J. Dawson, Simon H. J. Brown, James C. Bouwer, Gökhan Tolun, Peter J. Lewis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled transcription complexes. Here the authors provide mechanistic insights into this process by determining the cryo-EM structures of the Bacillus subti
Externí odkaz:
https://doaj.org/article/5ba51ba3f90b4dc994ae7757d1617c0b
Publikováno v:
MicrobiologyOpen, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Efficient control of transcription is essential in all organisms. In bacteria, where DNA replication and transcription occur simultaneously, the replication machinery is at risk of colliding with highly abundant transcription complexes. This
Externí odkaz:
https://doaj.org/article/e42de38e8b27420b80d2dd5bee1e21e4
Autor:
Bishnu P Paudel, Zhi-Qiang Xu, Slobodan Jergic, Aaron J Oakley, Nischal Sharma, Simon H J Brown, James C Bouwer, Peter J Lewis, Nicholas E Dixon, Antoine M van Oijen, Harshad Ghodke
Publikováno v:
Nucleic Acids Research. 50:5688-5712
Elongation by RNA polymerase is dynamically modulated by accessory factors. The transcription-repair coupling factor (TRCF) recognizes paused/stalled RNAPs and either rescues transcription or initiates transcription termination. Precisely how TRCFs c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d754bc44b6afec8ffad4a76fb6ce965
https://doi.org/10.1093/nar/gkac449
https://doi.org/10.1093/nar/gkac449
Autor:
Dmitry Shishmarev, Emily Rowland, Shouvik Aditya, Srinivasan Sundararaj, Aaron J. Oakley, Angela F. Dulhunty, Marco G. Casarotto
Publikováno v:
Protein Science. 31
Excitation-contraction coupling (ECC) is the physiological process in which an electrical signal originating from the central nervous system is converted into muscle contraction. In skeletal muscle tissue, the key step in the molecular mechanism of E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd4797b0fd3af0888031a6d45862e7a
https://doi.org/10.1002/pro.4311
https://doi.org/10.1002/pro.4311
Autor:
Aaron J Oakley
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154899 (2016)
A range of enzymes in DNA replication and repair bind to DNA-clamps: torus-shaped proteins that encircle double-stranded DNA and act as mobile tethers. Clamps from viruses (such as gp45 from the T4 bacteriophage) and eukaryotes (PCNAs) are homotrimer
Externí odkaz:
https://doaj.org/article/3e5f31723b16458f91b2ba6d326495e4
Autor:
Catherine J. Dawson, James C. Bouwer, Aaron J. Oakley, Timothy P. Newing, Michael Miller, Gökhan Tolun, Simon H. J. Brown, Peter J. Lewis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbd5a86daf62c7e4affdce7537a600d
https://doaj.org/article/5ba51ba3f90b4dc994ae7757d1617c0b
https://doaj.org/article/5ba51ba3f90b4dc994ae7757d1617c0b
Autor:
Girdhar Singh Deora, Aaron J. Oakley, Philip G. Board, Yuji Nakano, Jayme L. Dahlin, Padmaja Tummala, Jonathan B. Baell, Jessica M. Strasser, Yiyue Xie, Michael A. Walters, Melissa Rooke, Matthew E. Cuellar, Marco G. Casarotto
Publikováno v:
Journal of Medicinal Chemistry. 63:2894-2914
Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-molecule inhibitors are sought. The potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d34d91fc9b9fcdcb3312475033c026
https://doi.org/10.1021/acs.jmedchem.9b01391
https://doi.org/10.1021/acs.jmedchem.9b01391
Autor:
Zorik Chilingaryan, Stephen J. Headey, Allen T. Y. Lo, Zhi-Qiang Xu, Gottfried Otting, Nicholas E. Dixon, Martin J. Scanlon, Aaron J. Oakley
Publikováno v:
Antibiotics, Vol 7, Iss 1, p 14 (2018)
In bacteria, the DnaG primase is responsible for synthesis of short RNA primers used to initiate chain extension by replicative DNA polymerase(s) during chromosomal replication. Among the proteins with which Escherichia coli DnaG interacts is the sin
Externí odkaz:
https://doaj.org/article/9c5e2099c6f7403fa551c8523a04181d