Výsledky vyhledávání - "Aaron J Schetter"

Akademický článek

Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer.

Autor: Yukiharu Hiyoshi, Aaron J Schetter, Hirokazu Okayama, Kentaro Inamura, Katsuhiro Anami, Giang H Nguyen, Izumi Horikawa, Jason E Hawkes, Elise D Bowman, Suet Yi Leung, Curtis C Harris

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124899 (2015)

The microRNA-34 family (miR-34a, -34b and -34c) have been reported to be tumor suppressor microRNAs (miRNAs) that are regulated by the TP53 and DNA hypermethylation. However, the expression, regulation, and prognostic value of the miR-34 family have

Externí odkaz: https://doaj.org/article/6039234f244441dda979d6fc5a37b6e1

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Akademický článek

The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.

Autor: Xiangli Cui, Erin E Witalison, Alena P Chumanevich, Alexander A Chumanevich, Deepak Poudyal, Venkataraman Subramanian, Aaron J Schetter, Curtis C Harris, Paul R Thompson, Lorne J Hofseth

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53791 (2013)

Protein Arginine Deiminases (PADs) catalyze the post-translational conversion of peptidyl-Arginine to peptidyl-Citrulline in a calcium-dependent, irreversible reaction. Evidence is emerging that PADs play a role in carcinogenesis. To determine the ca

Externí odkaz: https://doaj.org/article/d8a08a5fc2544ca983c8aab0e1822946

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Akademický článek

A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng.

Autor: Deepak Poudyal, Xiangli Cui, Phuong Mai Le, Anne B Hofseth, Anthony Windust, Mitzi Nagarkatti, Prakash S Nagarkatti, Aaron J Schetter, Curtis C Harris, Lorne J Hofseth

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e75034 (2013)

Metastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anti-cance

Externí odkaz: https://doaj.org/article/9952560ba7e6469bb69607747125f1d3

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Akademický článek

Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.

Autor: Jane J Sohn, Aaron J Schetter, Harris G Yfantis, Lisa A Ridnour, Izumi Horikawa, Mohammed A Khan, Ana I Robles, S Perwez Hussain, Akiteru Goto, Elise D Bowman, Lorne J Hofseth, Jirina Bartkova, Jiri Bartek, Gerald N Wogan, David A Wink, Curtis C Harris

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44156 (2012)

BACKGROUND:Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between senescence and DDR with mac

Externí odkaz: https://doaj.org/article/77068782f8484d4388da497fddb461d0

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Akademický článek

Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis.

Autor: Hanyin Cheng, Lina Zhang, David E Cogdell, Hong Zheng, Aaron J Schetter, Matti Nykter, Curtis C Harris, Kexin Chen, Stanley R Hamilton, Wei Zhang

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17745 (2011)

Colorectal cancer (CRC) remains one of the major cancer types and cancer related death worldwide. Sensitive, non-invasive biomarkers that can facilitate disease detection, staging and prediction of therapeutic outcome are highly desirable to improve

Externí odkaz: https://doaj.org/article/27d2b86442c242d8ac46981e967ebf55

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