Sustained inhibition of NPY/AgRP neuronal activity by FGF1

Autor: Eunsang Hwang, Jarrad M. Scarlett, Arian F. Baquero, Camdin M. Bennett, Yanbin Dong, Dominic Chau, Jenny M. Brown, Aaron J. Mercer, Thomas H. Meek, Kevin L. Grove, Bao Anh N. Phan, Gregory J. Morton, Kevin W. Williams, Michael W. Schwartz

Publikováno v: JCI Insight, Vol 7, Iss 17 (2022)

In rodent models of type 2 diabetes (T2D), central administration of FGF1 normalizes elevated blood glucose levels in a manner that is sustained for weeks or months. Increased activity of NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) is

Externí odkaz: https://doaj.org/article/df6556bb07904915ad6da9a771a2e516

Profiling Mouse Brown and White Adipocytes to Identify Metabolically Relevant Small ORFs and Functional Microproteins

Autor: Thomas F. Martinez, Sally Lyons-Abbott, Angie L. Bookout, Cynthia Donaldson, Joan M. Vaughan, Calvin Lau, Ariel Abramov, Arian F. Baquero, Karalee Baquero, Dave Friedrich, Justin Huard, Ray Davis, Bong Kim, Ty Koch, Aaron J. Mercer, Ayesha Misquith, Sara A. Murray, Sakara Perry, Lindsay K. Pino, Christina Sanford, Alex Simon, Yu Zhang, Garrett Zipp, Maxim N. Shokhirev, Andrew J. Whittle, Brian C. Searle, Michael J. MacCoss, Alan Saghatelian, Christopher A. Barnes

SUMMARYThe absence of thousands of recently annotated small open reading frame (smORF)-encoded peptides and small proteins (microproteins) from databases has precluded their analysis in metabolism and metabolic disease. Given the outsized importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c60053f4cebe996605878d3dbc60b0b
https://doi.org/10.1101/2022.03.12.484025

NPFF Decreases Activity of Human Arcuate NPY Neurons: A Study in Embryonic-Stem-Cell-Derived Model

Autor: Lola Torz, Kristoffer Niss, Sofia Lundh, Jens C. Rekling, Carlos Damian Quintana, Signe Emilie Dannulat Frazier, Aaron J. Mercer, Anda Cornea, Charlotte Vinther Bertelsen, Marina Kjærgaard Gerstenberg, Ann Maria Kruse Hansen, Mette Guldbrandt, Jens Lykkesfeldt, Linu Mary John, J. Carlos Villaescusa, Natalia Petersen

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3260
Torz, L, Niss, K, Lundh, S, Rekling, J C, Quintana, C D, Frazier, S E D, Mercer, A J, Cornea, A, Bertelsen, C V, Gerstenberg, M K, Hansen, A M K, Guldbrandt, M, Lykkesfeldt, J, John, L M, Villaescusa, J C & Petersen, N 2022, ' NPFF Decreases Activity of Human Arcuate NPY Neurons : A Study in Embryonic-Stem-Cell-Derived Model ', International Journal of Molecular Sciences, vol. 23, no. 6, 3260 . https://doi.org/10.3390/ijms23063260

Restoring the control of food intake is the key to obesity management and prevention. The arcuate nucleus (ARC) of the hypothalamus is extensively being studied as a potential anti-obesity target. Animal studies showed that neuropeptide FF (NPFF) red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb1075b5312e468a62bab39485ceb3a
https://doi.org/10.3390/ijms23063260

Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment

Autor: Tess Tsai Hsiu Lu, Kasper Marstal, Lotte Bjerre Knudsen, Knut Conradsen, Casper Gravesen Salinas, Anders Bjorholm Dahl, Jacob Hecksher-Sørensen, Sanaz Gabery, Anna Secher, Aaron J. Mercer, Tomas Alanentalo, Anda Cornea

Publikováno v: Salinas, C B G, Lu, T T H, Gabery, S, Marstal, K, Alanentalo, T, Mercer, A J, Cornea, A, Conradsen, K, Hecksher-Sørensen, J, Dahl, A B, Knudsen, L B & Secher, A 2018, ' Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment ', Scientific Reports, vol. 8, no. 1, 10310 . https://doi.org/10.1038/s41598-018-28496-6
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports, 8:10310. Nature Publishing Group

Light Sheet Fluorescence Microscopy (LSFM) of whole organs, in particular the brain, offers a plethora of biological data imaged in 3D. This technique is however often hindered by cumbersome non-automated analysis methods. Here we describe an approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702f32f44771f707e197f3cd05ced199
https://orbit.dtu.dk/en/publications/6bc1039c-723b-4b61-b42f-1a2e139eb81e

The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform

Autor: Karin, Hultman, Jarrad M, Scarlett, Arian F, Baquero, Anda, Cornea, Yu, Zhang, Casper B G, Salinas, Jenny, Brown, Gregory J, Morton, Erin J, Whalen, Kevin L, Grove, Frank H, Koegler, Michael W, Schwartz, Aaron J, Mercer

Publikováno v: J Comp Neurol

Central activation of fibroblast growth factor (FGF) receptors regulates peripheral glucose homeostasis and reduces food intake in preclinical models of obesity and diabetes. The current work was undertaken to advance our understanding of the recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9fefff4fe1f977b93d215f3e018f224
https://pubmed.ncbi.nlm.nih.gov/30809795