Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Aaron J Gruber"'
Publikováno v:
eLife, Vol 9 (2020)
Psychostimulants such as d-amphetamine (AMPH) often have behavioral effects that appear paradoxical within the framework of optimal choice theory. AMPH typically increases task engagement and the effort animals exert for reward, despite decreasing re
Externí odkaz:
https://doaj.org/article/a348e5f11a734524a1f63947c93ab7c3
Publikováno v:
eLife, Vol 7 (2018)
The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat’s position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of t
Externí odkaz:
https://doaj.org/article/ba68373170dc41c89504bae9276c71cb
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85842 (2014)
Antagonists of N-methyl-D-aspartate receptors (NMDAR) have psychotomimetic effects in humans and are used to model schizophrenia in animals. We used high-density electrophysiological recordings to assess the effects of acute systemic injection of an
Externí odkaz:
https://doaj.org/article/6d33609dcfb3406c9a150f8b983732be
Autor:
Aaron J Gruber, Robert J McDonald
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 6 (2012)
Motivated behaviour exhibits properties that change with experience and partially dissociate among a number of brain structures. Here, we review evidence from rodent experiments demonstrating that multiple brain systems acquire information in paralle
Externí odkaz:
https://doaj.org/article/6b82e0cca8cb44cf93856ea41dc24389
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5062 (2009)
Reward intake optimization requires a balance between exploiting known sources of rewards and exploring for new sources. The prefrontal cortex (PFC) and associated basal ganglia circuits are likely candidates as neural structures responsible for such
Externí odkaz:
https://doaj.org/article/6ef6aaf4c2624b9a8671d0684f52ddbb
Autor:
Chelsea E. Matisz, Nadia Semenoff, Al-Shaimaa F. Ahmed, Lateece Griffin, Laurie E. Wallace, Parker McNabb, Robbin Gibb, Keith A. Sharkey, Aaron J. Gruber
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Gastrointestinal tract (gut) inflammation increases stress and threat-coping behaviors, which are associated with altered activity in fear-related neural circuits, such as the basolateral amygdala and hippocampus. It remains to be determined
Externí odkaz:
https://doaj.org/article/71709adf62014e6ea4f070f3e9540d83
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 16 (2022)
When the outcome of a choice is less favorable than expected, humans and animals typically shift to an alternate choice option on subsequent trials. Several lines of evidence indicate that this “lose-shift” responding is an innate sensorimotor re
Externí odkaz:
https://doaj.org/article/ca3cb94829384e9b92f31cd25715ad0e
Publikováno v:
Information Sciences. 639:118999
Publikováno v:
Stress (Amsterdam, Netherlands). 24(5)
Chronic stress evokes wide-ranging behavioral alterations, including risk avoidance, increased motoric output, and reduced consummatory behaviors. These are often interpreted as dysfunctions, but they may subserve adaptations for coping with existent
Publikováno v:
Neuroscience Letters. 692:159-166
Multiple neural systems contribute to choice adaptation following reinforcement. Recent evidence suggests that the lateral habenula (LHb) plays a key role in such adaptations, particularly when reinforcements are worse than expected. Here, we investi