Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Aaron H. Phillips"'
Autor:
Furqan Dar, Samuel R. Cohen, Diana M. Mitrea, Aaron H. Phillips, Gergely Nagy, Wellington C. Leite, Christopher B. Stanley, Jeong-Mo Choi, Richard W. Kriwacki, Rohit V. Pappu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The functions of biomolecular condensates are thought to be influenced by their material properties, and these will be determined by the internal organization of molecules within condensates. However, structural characterizations of condensa
Externí odkaz:
https://doaj.org/article/c93f7762b30c44859a29f3a08ec49c86
Autor:
Jun Zhan, Frank Harwood, Sara Ten Have, Angus Lamond, Aaron H. Phillips, Richard W. Kriwacki, Priyanka Halder, Monica Cardone, Gerard C. Grosveld
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10042 (2024)
mTOR plays a crucial role in cell growth by controlling ribosome biogenesis, metabolism, autophagy, mRNA translation, and cytoskeleton organization. It is a serine/threonine kinase that is part of two distinct extensively described protein complexes,
Externí odkaz:
https://doaj.org/article/bd0857ad081b45ab8b156bf4a39987f5
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Autor:
Maksym Tsytlonok, Hugo Sanabria, Yuefeng Wang, Suren Felekyan, Katherina Hemmen, Aaron H. Phillips, Mi-Kyung Yun, M. Brett Waddell, Cheon-Gil Park, Sivaraja Vaithiyalingam, Luigi Iconaru, Stephen W. White, Peter Tompa, Claus A. M. Seidel, Richard Kriwacki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation. Here the authors use an integrated a
Externí odkaz:
https://doaj.org/article/68150062dc9d4c4082ba200461d73f70
Autor:
Diana M. Mitrea, Jaclyn A. Cika, Christopher B. Stanley, Amanda Nourse, Paulo L. Onuchic, Priya R. Banerjee, Aaron H. Phillips, Cheon-Gil Park, Ashok A. Deniz, Richard W. Kriwacki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 int
Externí odkaz:
https://doaj.org/article/b0e551cefaf8425ca521312004e29d42
Autor:
Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R. Downing, Tanja A. Gruber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical
Externí odkaz:
https://doaj.org/article/b6c8588bcf0a40118828477b2bfbf11e
Publikováno v:
Biophysical Journal. 122:475a
Autor:
Swati Kinger, Brittany J. Pioso, Swarnendu Tripathi, Aaron H. Phillips, Cheon-Gil Park, Snigdha Maiti, Scott D. Gorman, Gitanjali Asampille, Fnu Wahiduzzaman, Toler Freyaldenhoven, David W. Baggett, Hazheen Shirnekhi, Bappaditya Chandra, Richard Kriwacki
Publikováno v:
Biophysical Journal. 122:345a
Autor:
Brittany J. Pioso, Nicole L. Michmerhuizen, Swarnendu Tripathi, Toler Freyaldenhoven, Aaron H. Phillips, Charles G. Mullighan, Richard Kriwacki
Publikováno v:
Biophysical Journal. 122:486a
Autor:
Aaron H. Phillips, Richard W. Kriwacki
Publikováno v:
Current Opinion in Structural Biology. 60:1-6
Eukaryotic cells are highly complex systems; however, they manage to attain this complexity with a surprisingly small number of protein products. This is due, in part, to the fact that the functions of the eukaryotic proteome can be modulated and con
Autor:
Jacquelyn Powers, Michael R. Clay, Jinling Wang, Suzanne P. MacFarland, Maria N. Formiga, Michael Walsh, Carlos Rodriguez-Galindo, Raul C. Ribeiro, Hadeel Halalsheh, Richard W. Kriwacki, Roya Mostafavi, Aaron H. Phillips, Kim E. Nichols, Kara N. Maxwell, Emilia M. Pinto, Gerard P. Zambetti, Kelsey Breen
Publikováno v:
Mol Cancer Res
Germline TP53 splicing variants are uncommon, and their clinical relevance is unknown. However, splice-altering variants at exon 4–intron 4 junctions are relatively enriched in pediatric adrenocortical tumors (ACT). Nevertheless, family histories o