Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

Autor: Varsha Thoppey Manoharan, Aly Abdelkareem, Gurveer Gill, Samuel Brown, Aaron Gillmor, Courtney Hall, Heewon Seo, Kiran Narta, Sean Grewal, Ngoc Ha Dang, Bo Young Ahn, Kata Osz, Xueqing Lun, Laura Mah, Franz Zemp, Douglas Mahoney, Donna L. Senger, Jennifer A. Chan, A. Sorana Morrissy

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-32 (2024)

Abstract Background Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistance to conventional therapies, and dismal prognosis in patients. A deeper understanding of how components of t

Externí odkaz: https://doaj.org/article/f1033c8340dd4063abee32d40fee97cd

Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer

Autor: Aaron Gillmor, Marco Gallo, Paola Neri, Nizar J. Bahlis, Steven J.M. Jones, Yaoqing Shen, Katrina Ellestad, Divya Singhal, Mathieu Lupien, Michael J. Johnston, Jennifer A. Chan, J. Gregory Cairncross, Ana Nikolic, Sorana Morrissy

Publikováno v: Science Advances

Description
Inferring structural variants in cancer single-cell chromatin accessibility data links genetics to chromatin organization.
Single-cell epigenomic assays have tremendous potential to illuminate mechanisms of transcriptional contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e36b5206d5ca539eca7fe41915acd4c
https://doi.org/10.1126/sciadv.abg6045

The transcriptional landscape of Shh medulloblastoma

Autor: Jaume Mora, Erwin G. Van Meir, Olivier Delattre, Diala Abd-Rabbo, Almos Klekner, Peter Hauser, Roger E. McLendon, Amulya A. Nageswara Rao, David Malkin, James M. Olson, Boleslaw Lach, A. Sorana Morrissy, Xiaoyun Zhang, John J.Y. Lee, Steven J.M. Jones, Young Shin Ra, Ulrich Schüller, Miklós Garami, Joanna J. Phillips, Betty Luu, Hamza Farooq, Johan M. Kros, Karel Zitterbart, Michael K. Cooper, Raul Suarez, William A. Weiss, Quang M. Trinh, Ana Guerreiro Stucklin, Tomoko Shofuda, Carmen de Torres, Marco A. Marra, Enrique López-Aguilar, Hiromichi Suzuki, Patryk Skowron, Eric Bouffet, Karen Mungall, Evan Y. Wang, Tina Zheng, Maria C. Vladoiu, Julien Masliah-Planchon, Ian F. Pollack, Wai Sang Poon, Liam D. Hendrikse, Claudia C. Faria, Yu Chang Wang, Kay Ka Wai Li, Carlos Gilberto Carlotti, Joshua B. Rubin, Gary D. Bader, Aaron Gillmor, Caterina Giannini, Uri Tabori, Shin Jung, Franck Bourdeaut, Chi-chung Hui, Avesta Rastan, Reid C. Thompson, Jennifer A. Chan, Nada Jabado, David Meyronet, Rajeev Vibhakar, Jiannis Ragoussis, Michelle Ly, Olivier Ayrault, Charles G. Eberhart, Andrew J. Mungall, Wiesława Grajkowska, Xiaochong Wu, Jüri Reimand, Ho Keung Ng, Vernon Fong, Michael D. Taylor, Seung-Ki Kim, Florence M.G. Cavalli, Carolina Nor, Helen He Zhu, Eric M. Thompson, Borja L. Holgado, David Zagzag, Craig Daniels, Gelareh Zadeh, Haig Djambazian, G. Yancey Gillespie, Peter B. Dirks, Richard A. Moore, John A. Calarco, Shizhong Dai, Vijay Ramaswamy, Lincoln Stein, Pierre Bérubé, Pim J. French, Toshihiro Kumabe, James Loukides, Swneke D. Bailey, Linda M. Liau, Ronald L. Hamilton, Francois P. Doz, Maria Luisa Garrè, László Bognár

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12, pp.1749. ⟨10.1038/s41467-021-21883-0⟩
Nature communications, vol 12, iss 1
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, 12(1):1749. Nature Publishing Group
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
NATURE COMMUNICATIONS
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2137115d6e36188a53e6a0ba7dbaf248
https://hal.archives-ouvertes.fr/hal-03405528/file/Skowron_Nat_com_2021.pdf

Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Autor: Peter B. Dirks, Stephen W. Scherer, Fiona J. Coutinho, Lucie Lafay-Cousin, Florence M.G. Cavalli, Yussanne Ma, Jennifer A. Chan, Michelle Kushida, Kiran Narta, Mary Hoffman, Michael D Taylor, Michael J. Johnston, Andrew J. Mungall, Mehdi Zarrei, Benjamin D. Simons, Adam C. Resnick, Katrina Ellestad, Marco Gallo, Marco A. Marra, Trevor J. Pugh, Daniel J Kunz, Jennifer King, Richard A. Moore, Douglas Strother, A. Sorana Morrissy, Yuankun Zhu, Betty Luu, Donna L. Senger, Aaron Gillmor, Ngoc Ha Dang, Ana Nikolic

Publikováno v: Cancer Res

Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed whole-genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29be6a58c0d3861151fee1222685e4cb
https://www.repository.cam.ac.uk/handle/1810/290090