NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF

Autor: Mitchell E. Fane, Yash Chhabra, David E.J. Hollingsworth, Jacinta L. Simmons, Loredana Spoerri, Tae Gyu Oh, Jagat Chauhan, Toby Chin, Lachlan Harris, Tracey J. Harvey, George E.O. Muscat, Colin R. Goding, Richard A Sturm, Nikolas K. Haass, Glen M. Boyle, Michael Piper, Aaron G. Smith

Publikováno v: EBioMedicine, Vol 16, Iss C, Pp 63-75 (2017)

While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to u

Externí odkaz: https://doaj.org/article/1d9c7e7e95224d40a32f42bb4b0ce6d1

SWIR for the Assessment of Heart Failure

Autor: J. Christopher Post, Matthew P. Nelson, Robert C. Schweitzer, Marlena B. Darr, Shona D. Stewart, Aaron G. Smith, Patrick J. Treado

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04b7919c7996598ad98dd5b5dbf27690
https://doi.org/10.1117/3.2604326.ch11

Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion

Autor: Mitchell E. Fane, Yash Chhabra, Loredana Spoerri, Jacinta L. Simmons, Raquelle Ludwig, Elise Bonvin, Colin R. Goding, Richard A. Sturm, Glen M. Boyle, Nikolas K. Haass, Michael Piper, Aaron G. Smith

Phenotypic plasticity drives cancer progression, impacts treatment response, and is a major driver of therapeutic resistance. In melanoma, a regulatory axis between the MITF and BRN2 transcription factors has been reported to promote tumor heterogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3042e17f105711e34d1fd1a7ecb80880
https://doi.org/10.1016/j.jid.2020.12.039

BRN2, aPOUerful driver of melanoma phenotype switching and metastasis

Autor: Aaron G. Smith, Yash Chhabra, Richard A. Sturm, Mitchell Fane

Publikováno v: Pigment Cell & Melanoma Research. 32:9-24

The POU domain family of transcription factors play a central role in embryogenesis and are highly expressed in neural crest cells and the developing brain. BRN2 is a class III POU domain protein that is a key mediator of neuroendocrine and melanocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba95a696fcd1627743eb7d0179f82e87
https://doi.org/10.1111/pcmr.12710

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Autor: Frederic A. Meunier, Andreas Papadopulos, Michael J. Waters, Yash Chhabra, Birthe B. Kragelund, Ho Yi Wong, Helena Steinocher, Louise F. Nikolajsen, Kathryn A. Tunny, Aaron G. Smith, Andrew J. Brooks

Publikováno v: Oncogene
Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J & Waters, M J 2018, ' A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation ', Oncogene, vol. 37, pp. 489-501 . https://doi.org/10.1038/onc.2017.352

Both humans and mice lacking functional growth hormone (GH) receptors are known to be resistant to cancer. Further, autocrine GH has been reported to act as a cancer promoter. Here we present the first example of a variant of the GH receptor (GHR) as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a81d5f9d47c1a41e18529c63aa687af
https://doi.org/10.1038/onc.2017.352