Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Aaron G Smith"'
Autor:
Kasturee Jagirdar, Kelvin Yin, Matthew Harrison, Wen Lim, George E O Muscat, Richard A Sturm, Aaron G Smith
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78075 (2013)
Ultraviolet radiation (UVR) is one of the most common mutagens encountered by humans and induces the formation of cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone photoproduct (6-4PP) lesions in the genomic DNA. To prevent the acc
Externí odkaz:
https://doaj.org/article/602537e14a0e4b698ed8de6d08e6c349
Autor:
Aaron G. Smith, Richard A. Sturm, Eloise Dray, Mitchell Fane, Yi Chieh Lim, Romain Tropée, Yash Chhabra, Kelvin Yin
Supplementary Fig. S1. Nuclear foci characterisation of wild-type and mutant NR4A2 isoforms in mock and UVB conditions. Supplementary Fig. S2. NR4A2 expression protects cells after UVB radiation. A2058 and HT144 cells stably expressing Empty, NR4A2WT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a12bb05bcfb665a62b2598aba533207
https://doi.org/10.1158/1541-7786.22515003
https://doi.org/10.1158/1541-7786.22515003
Autor:
Robert Schweitzer, Arjun S. Bangalore, Reina Perez, Jeffrey A. Cohen, Heather Gomer, Aaron G. Smith, Shona Stewart, Sandhya Vasudevan, Marlena Darr, J. Christopher Post, Aaron Thomas, Arash Samiei, Srinivas Murali, Patrick J. Treado
Publikováno v:
Journal of Biomedical Optics
Significance: Peripheral pitting edema is a clinician-administered measure for grading edema. Peripheral edema is graded 0, 1 + , 2 + , 3 + , or 4 + , but subjectivity is a major limitation of this technique. A pilot clinical study for short-wave inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5167fc3da7583787c1002b99ebc9a8f
https://doi.org/10.1117/1.jbo.26.10.105002
https://doi.org/10.1117/1.jbo.26.10.105002
Autor:
Mitchell E. Fane, Yash Chhabra, Loredana Spoerri, Jacinta L. Simmons, Raquelle Ludwig, Elise Bonvin, Colin R. Goding, Richard A. Sturm, Glen M. Boyle, Nikolas K. Haass, Michael Piper, Aaron G. Smith
Phenotypic plasticity drives cancer progression, impacts treatment response, and is a major driver of therapeutic resistance. In melanoma, a regulatory axis between the MITF and BRN2 transcription factors has been reported to promote tumor heterogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3042e17f105711e34d1fd1a7ecb80880
https://doi.org/10.1016/j.jid.2020.12.039
https://doi.org/10.1016/j.jid.2020.12.039
Autor:
Ethan K. Scott, Samantha J. Stehbens, Jagat Chauhan, Aaron G. Smith, Glen M. Boyle, David S. Hill, Colin R. Goding, Russell J Jurek, Sheena M. Daignault-Mill, Mitchell Fane, Gency Gunasingh, Brian Gabrielli, Nicholas Matigian, Wolfgang Weninger, Kimberley A. Beaumont, Gilles Vanwalleghem, Crystal A Tonnessen-Murray, Loredana Spoerri, Helmut Schaider, Nikolas K. Haass
Phenotypic heterogeneity of cancer cells plays a critical role in shaping treatment response. This type of heterogeneity is organized spatially with specific phenotypes, such as sharply demarcated clusters of proliferating and cell cycle-arrested cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830ac02b4104d8d31185d81d0ffb827f
https://doi.org/10.1101/2020.06.09.141747
https://doi.org/10.1101/2020.06.09.141747
Publikováno v:
Pigment Cell & Melanoma Research. 32:9-24
The POU domain family of transcription factors play a central role in embryogenesis and are highly expressed in neural crest cells and the developing brain. BRN2 is a class III POU domain protein that is a key mediator of neuroendocrine and melanocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba95a696fcd1627743eb7d0179f82e87
https://doi.org/10.1111/pcmr.12710
https://doi.org/10.1111/pcmr.12710
Autor:
B. Mark Smithers, Andrew Barbour, Michael David, Tavis Read, Janine Thomas, Aaron G. Smith, Matthew Foote, Michael Wagels
Publikováno v:
Journal of Surgical Oncology
Background: Patients with in-transit melanoma metastases frequently experience high rates of recurrence, limited overall survival and reduced quality of life. After promising results within a Phase II, multi-center study, PV-10 treatment was continue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d310805370182858906da623438d7f8
http://europepmc.org/articles/PMC6668008
http://europepmc.org/articles/PMC6668008
Autor:
Frederic A. Meunier, Andreas Papadopulos, Michael J. Waters, Yash Chhabra, Birthe B. Kragelund, Ho Yi Wong, Helena Steinocher, Louise F. Nikolajsen, Kathryn A. Tunny, Aaron G. Smith, Andrew J. Brooks
Publikováno v:
Oncogene
Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J & Waters, M J 2018, ' A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation ', Oncogene, vol. 37, pp. 489-501 . https://doi.org/10.1038/onc.2017.352
Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J & Waters, M J 2018, ' A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation ', Oncogene, vol. 37, pp. 489-501 . https://doi.org/10.1038/onc.2017.352
Both humans and mice lacking functional growth hormone (GH) receptors are known to be resistant to cancer. Further, autocrine GH has been reported to act as a cancer promoter. Here we present the first example of a variant of the GH receptor (GHR) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a81d5f9d47c1a41e18529c63aa687af
https://doi.org/10.1038/onc.2017.352
https://doi.org/10.1038/onc.2017.352
Autor:
Mitchell Fane, Aaron G. Smith, Kelvin Yin, Richard A. Sturm, Eloise Dray, Yi Chieh Lim, Yash Chhabra, Romain Tropée
Publikováno v:
Molecular Cancer Research. 15:1184-1196
Exposure of melanocytes to ultraviolet radiation (UVR) induces the formation of UV lesions that can produce deleterious effects in genomic DNA. Encounters of replication forks with unrepaired UV lesions can lead to several complex phenomena, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416d11bf3537b549e8aee73c1f8a027a
https://doi.org/10.1158/1541-7786.mcr-17-0002
https://doi.org/10.1158/1541-7786.mcr-17-0002