Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aaron Fulgham"'
683 A novel mechanism of neuropilin-1 inhibition results in improved tumor growth inhibition in vivo
Autor:
Eric Zhu, Daniel Blom, Shalini Sethumadhavan, Chengfeng Merriman, Katherine Molloy, Alexandria Fink, Shan Lou, Andrew Rogantino, Ameya Apte, Mandana abbassi, Tiffany Liao, Hongyue Dai, Aaron Fulgham, Jonathan Hurov, Pearl Huang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/eb8c2e1b1f54498abc86b8a7c8000d7d
Autor:
Kwok-Kin Wong, Jeffrey A. Engelman, Ulrik B. Nielsen, Youngchul Song, Aaron Fulgham, Lin Nie, Zandra Walton, Emily Pace, Olga Burenkova, Matthew Onsum, Katherine Crosby, Mei-Chih Liang, Danan Li, Anthony C. Faber, Birgit Schoeberl
Supplementary Methods, Figures 1-8, Table 1 from An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156ef0fc867f4fa59fe97a8529ab0e55
https://doi.org/10.1158/0008-5472.22386953
https://doi.org/10.1158/0008-5472.22386953
Autor:
Brian H. White, Yaguang Si, Sarah Cappucci, Zhi Li, Jessica D. Ramirez, Charles M. Ponthier, Erica Visness, Peicheng Du, Minjung Choi, Pieter C. Beerepoot, Paula C. Ortet, Ivan T. Jewett, Josue Alfaro-Lopez, Sorabh Agarwal, Daniel La, Aaron Fulgham, John H. McGee, Keith Orford, Jonathan B. Hurov, Martin R. Tremblay, Gregory L. Verdine
Publikováno v:
Cancer Research. 83:3094-3094
Wnt signaling pathway mutations leading to constitutive activation of the driver oncogene β-catenin occur in at least 20% of all human cancers, but β-catenin itself has remained undruggable by traditional modalities. In order to inhibit the activit
Autor:
YaGuang Si, Minjung Choi, Xinwei Han, Brian White, Ziyang Wu, Erica Visness, Pieter Beerepoot, Elizabeth Jaensch, Jessica Ramirez, Charles Ponthier, Xiaogang Han, Paula Ortet, Peicheng Du, Sorabh Agarwal, Mirek Lech, Aaron Fulgham, Sarah Cappucci, Zhi Li, John McGee, Lihua Yu, Martin Tremblay, Keith Orford, Gregory Verdine, Jonathan Hurov
Publikováno v:
Cancer Research. 83:4972-4972
Genetic and epigenetic alterations in the Wnt signaling pathway leading to constitutive activation of the driver oncogene Β-catenin occur in at least 20% of all human cancers. We have developed conformationally hyperstabilized α-helical peptides (H
Autor:
Ashish Kalra, Jeffrey D. Kearns, Adnan O. Abu-Yousif, Gavin MacBeath, Alexey Lugovskoy, Maria Håkansson, Derek T. Logan, Birgit Schoeberl, Martin Welin, Melissa Geddie, Ulrik B. Nielsen, Neeraj Kohli, Tim Maiwald, Jessica B. Casaletto, Aaron Fulgham, Brian Harms, Shrikanta Chattopadhyay, Stephen Su, Maja Razlog, Antoine Boudot, Kristina Masson, Andreas Raue
Publikováno v:
Proceedings of the National Academy of Sciences. 116:7533-7542
Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, meta
Autor:
Alexandra Lantermann, Eugene Chekler, Bruce Lefker, Garmen Yuen, Vanessa Lam, Matthew Strickland, Justyne Pennacchio, Aaron Fulgham, Dara Bree, Thomas Perekslis, Grazia Piizzi, Hongyue Dai, Tim Zheng, John Wagner, Pearl Huang
Publikováno v:
Cancer Research. 82:166-166
G Protein-Coupled Receptor Kinase 2 (Grk2) is a serine-threonine kinase widely expressed in the human body. The GRK family of kinases is known for its role in GPCR phosphorylation and desensitization upon GPCR activation by agonists. Besides its role
683 A novel mechanism of neuropilin-1 inhibition results in improved tumor growth inhibition in vivo
Autor:
Chengfeng Merriman, Aaron Fulgham, Mandana Abbassi, Alexandria Fink, Pearl S. Huang, Jonathan Hurov, Andrew Rogantino, Tiffany Liao, Eric Franklin Zhu, Hongyue Dai, Daniel Blom, Shalini Sethumadhavan, Ameya Apte, Katherine Molloy, Shan Lou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Neuropilin-1 (NRP1) is a co-receptor that complexes with diverse ligands and their cognate receptors. As such, it plays a role in multiple different biological processes, including axon guidance and angiogenesis. NRP1 contains two CUB doma
Autor:
Jonathan Hurov, Ameya Apte, Kiley Couto, Matthew Strickland, Pearl S. Huang, Mortada Najem, Aaron Fulgham, Alexandra Lantermann, Tiffany Liao
Publikováno v:
Molecular Cancer Therapeutics. 18:LB-C05
The pancreas is highly innervated with sensory, autonomic and enteric neurons, and recent studies have highlighted the crosstalk between neurons and pancreatic cells and their potential role in driving tumorigenesis and promoting metastasis. Publishe
Autor:
Jonathan Fitzgerald, Gavin MacBeath, Aaron Fulgham, Victor Moyo, Brian Harms, Emily Pace, Art Kudla, Gregory J. Finn, Viara P. Grantcharova, Jeff Kearns, Kristina Masson, Bambang Adiwijaya, Michael D. Curley, Gabriela Garcia, Ulrik B. Nielsen, Birgit Schoeberl, Bill Kubasek, Jaeyeon Kim, Olga Burenkova, Rachel Nering, Marisa Wainszelbaum, Sara Mathews, Ashish Kalra, Defne Yarar, Violette Paragas, Akos Czibere, Kip A. West
Publikováno v:
NPJ Systems Biology and Applications
The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR/ErbB1), human EGFR 2 (HER2/ErbB2), ErbB3/HER3, and ErbB4/HER4. The first two members of this family, EGFR and HER2, have been implicated in tu
Autor:
Kristina Masson, Aaron Fulgham, Gavin MacBeath, Ulrik B. Nielsen, Adnan O. Abu-Yousif, Birgit Schoeberl, Melissa Geddie, Jessica Casaletto
Publikováno v:
Cancer Research. 75:1690-1690
Purpose: MM-131 is a purely antagonistic, bispecific antibody that potently inhibits HGF/c-Met signaling by co-targeting the widely expressed tumor antigen EpCAM. The purpose of these studies is to uncover the mechanism by which MM-131 exhibits poten