Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Aaron E Darling"'
Autor:
Sidaswar Krishnan, Matthew Z DeMaere, Dominik Beck, Martin Ostrowski, Justin R Seymour, Aaron E Darling
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010683 (2023)
Prokaryotic evolution is influenced by the exchange of genetic information between species through a process referred to as recombination. The rate of recombination is a useful measure for the adaptive capacity of a prokaryotic population. We introdu
Externí odkaz:
https://doaj.org/article/b55bab9d946f48b5937b21ef62a30408
Autor:
Daniela Gaio, Matthew Z DeMaere, Kay Anantanawat, Graeme J Eamens, Linda Falconer, Toni A Chapman, Steven Djordjevic, Aaron E Darling
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270372 (2022)
Intensive farming practices can increase exposure of animals to infectious agents against which antibiotics are used. Orally administered antibiotics are well known to cause dysbiosis. To counteract dysbiotic effects, numerous studies in the past two
Externí odkaz:
https://doaj.org/article/643bb5e608c6405d9c91571509fe83a9
Autor:
Matthew Z DeMaere, Aaron E Darling
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008839 (2021)
Hi-C is a sample preparation method that enables high-throughput sequencing to capture genome-wide spatial interactions between DNA molecules. The technique has been successfully applied to solve challenging problems such as 3D structural analysis of
Externí odkaz:
https://doaj.org/article/fb8f07d6b62e4a17be3222af8fc8d2ca
Autor:
David A Coil, Guillaume Jospin, Aaron E Darling, Corrin Wallis, Ian J Davis, Stephen Harris, Jonathan A Eisen, Lucy J Holcombe, Ciaran O'Flynn
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0214354 (2019)
Taxonomy for bacterial isolates is commonly assigned via sequence analysis. However, the most common sequence-based approaches (e.g. 16S rRNA gene-based phylogeny or whole genome comparisons) are still labor intensive and subjective to varying degree
Externí odkaz:
https://doaj.org/article/baccc647a167433db5fd49cda44502d3
Autor:
Erin A Becker, Phillip M Seitzer, Andrew Tritt, David Larsen, Megan Krusor, Andrew I Yao, Dongying Wu, Dominique Madern, Jonathan A Eisen, Aaron E Darling, Marc T Facciotti
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004784 (2014)
Organisms across the tree of life use a variety of mechanisms to respond to stress-inducing fluctuations in osmotic conditions. Cellular response mechanisms and phenotypes associated with osmoadaptation also play important roles in bacterial virulenc
Externí odkaz:
https://doaj.org/article/e9dc9554f3b8489b89cc3f217baa901f
Autor:
Federico M Lauro, Svend Jacob Senstius, Jay Cullen, Russell Neches, Rachelle M Jensen, Mark V Brown, Aaron E Darling, Michael Givskov, Diane McDougald, Ron Hoeke, Martin Ostrowski, Gayle K Philip, Ian T Paulsen, Joseph J Grzymski
Publikováno v:
PLoS Biology, Vol 12, Iss 9, p e1001947 (2014)
Externí odkaz:
https://doaj.org/article/7065875eca1a40159db15293171ed020
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62510 (2013)
Over 3000 microbial (bacterial and archaeal) genomes have been made publically available to date, providing an unprecedented opportunity to examine evolutionary genomic trends and offering valuable reference data for a variety of other studies such a
Externí odkaz:
https://doaj.org/article/512400c595964b93a45603cd8e1dcb50
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e42304 (2012)
Remarkable advances in DNA sequencing technology have created a need for de novo genome assembly methods tailored to work with the new sequencing data types. Many such methods have been published in recent years, but assembling raw sequence data to o
Externí odkaz:
https://doaj.org/article/d171c67994c14df3adb5755987004490
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11147 (2010)
Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.We describe a new method to
Externí odkaz:
https://doaj.org/article/59f3f81481474677ace8de654549ce38
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10209 (2010)
BackgroundMicrobial life dominates the earth, but many species are difficult or even impossible to study under laboratory conditions. Sequencing DNA directly from the environment, a technique commonly referred to as metagenomics, is an important tool
Externí odkaz:
https://doaj.org/article/869659e109654998920a03203751339b