Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Aaron Diantonio"'
Autor:
Laura DeVault, Chase Mateusiak, John Palucki, Michael Brent, Jeffrey Milbrandt, Aaron DiAntonio
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0300539 (2024)
Genetic and pharmacological perturbation of the cytoskeleton enhances the regenerative potential of neurons. This response requires Dual-leucine Zipper Kinase (DLK), a neuronal stress sensor that is a central regulator of axon regeneration and degene
Externí odkaz:
https://doaj.org/article/43b39fdcbbcd4e89a6be7c2cf9545dfb
Publikováno v:
Cells, Vol 13, Iss 3, p 202 (2024)
We evaluated whether inhibiting sterile alpha and (Toll/interleukin receptor (TIR)) motif-containing 1 (SARM1) activity protects retinal ganglion cells (RGCs) following ischemic axonopathy (rodent nonarteritic anterior ischemic optic neuropathy: rNAI
Externí odkaz:
https://doaj.org/article/7710a82ecac24916a2621dbc5ff4a726
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-15 (2022)
Abstract Background In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish autoinhibition leadi
Externí odkaz:
https://doaj.org/article/d65223ac517c430493d55dc723359e47
Autor:
Lorenzo Lones, Aaron DiAntonio
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010581 (2023)
Glial cells play a critical role in maintaining homeostatic ion concentration gradients. Salt-inducible kinase 3 (SIK3) regulates a gene expression program that controls K+ buffering in glia, and upregulation of this pathway suppresses seizure behavi
Externí odkaz:
https://doaj.org/article/1607439a023d4509a337445eee592f88
Autor:
Caitlin B. Dingwall, Amy Strickland, Sabrina W. Yum, Aldrin K.Y. Yim, Jian Zhu, Peter L. Wang, Yurie Yamada, Robert E. Schmidt, Yo Sasaki, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. We identified 2 rare NMNAT2 missense variants in 2 brothers a
Externí odkaz:
https://doaj.org/article/1463d2560add407bbb4937358ec40312
Autor:
Yurie Sato-Yamada, Amy Strickland, Yo Sasaki, Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial abnormalities, but the mechanism underlying the axonal pathology is unknown. Steri
Externí odkaz:
https://doaj.org/article/a22016f1de27458fb151f9e0cd2dd534
Autor:
Mark A Zaydman, Alexander S Little, Fidel Haro, Valeryia Aksianiuk, William J Buchser, Aaron DiAntonio, Jeffrey I Gordon, Jeffrey Milbrandt, Arjun S Raman
Publikováno v:
eLife, Vol 11 (2022)
Cellular behaviors emerge from layers of molecular interactions: proteins interact to form complexes, pathways, and phenotypes. We show that hierarchical networks of protein interactions can be defined from the statistical pattern of proteome variati
Externí odkaz:
https://doaj.org/article/b0777089e53f4af9bf100c53466b6c9d
Autor:
E J Brace, Kow Essuman, Xianrong Mao, John Palucki, Yo Sasaki, Jeff Milbrandt, Aaron DiAntonio
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010246 (2022)
SARM1 is the founding member of the TIR-domain family of NAD+ hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+ hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1 was s
Externí odkaz:
https://doaj.org/article/87f9821d636d4fa39f09839fe6ebf516
Autor:
Margaret Hayne, Aaron DiAntonio
Publikováno v:
Neurobiology of Disease, Vol 163, Iss , Pp 105586- (2022)
Protein phosphatase 2A (PP2A) is a major cellular phosphatase with many protein substrates. As expected for a signaling molecule with many targets, inhibition of PP2A disrupts fundamental aspects of cellular physiology including cell division and sur
Externí odkaz:
https://doaj.org/article/f95786797e5c42bf9dc7b0279173dbed
Publikováno v:
eLife, Vol 10 (2021)
SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in the injured and diseased nervous system. While SARM1 activation and enzyme function are well defined, the cellular events downstream of SARM1 activity but prior t
Externí odkaz:
https://doaj.org/article/4877f3da02fe49ecbeaf4ea689071126