Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aaron DeBono"'
Autor:
Tracy M. Josephs, Le Vi Dinh, Aaron DeBono, Karen J. Gregory, Ben Capuano, Katie Leach, Andrew N. Keller
Publikováno v:
ChemMedChem. 16:3451-3462
The calcium-sensing receptor (CaSR) is a clinical target in the treatment of hyperparathyroidism and related diseases. However, clinical use of approved CaSR-targeting drugs such as cinacalcet ( 1 ) is limited due to adverse side effects including hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae6fb332a8d843eba78579a028bae17
https://doi.org/10.1002/cmdc.202100368
https://doi.org/10.1002/cmdc.202100368
Autor:
Jane E. Bourke, Jiayin Diao, Karen J. Gregory, Ben Capuano, Aaron DeBono, Katie Leach, Tracy M. Josephs
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] The CaSR is a class C G protein-coupled receptor (GPCR) that acts as a multimodal chemosensor to maintain diverse homeostatic functions. The CaSR is a clinical therapeutic target in hyperparathyroidism and has emerged as a putative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490e43c525fe6dc6f3ec03a60ec4e3cc
https://doi.org/10.1021/acsptsci.1c00046
https://doi.org/10.1021/acsptsci.1c00046
Autor:
Elham Khajehali, Aaron DeBono, Christopher J. Langmead, Arthur D. Conigrave, Ben Capuano, Tracy M. Josephs, Karen J. Gregory, Katie Leach, Irina Kufareva, Andrew N. Keller
Publikováno v:
British journal of pharmacology, vol 177, iss 8
Br J Pharmacol
Br J Pharmacol
Background and purpose Negative allosteric modulators (NAMs) that target the calcium-sensing receptor (CaS receptor) were originally developed for the treatment of osteoporosis by stimulating the release of endogenous parathyroid hormone, but failed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9600bc6fa0ab8e4daccda0683b1a0c
https://escholarship.org/uc/item/9kc638dm
https://escholarship.org/uc/item/9kc638dm
Autor:
Richard Callaghan, Ben Capuano, Peter J. Scammells, Divya Muthiah, Aaron DeBono, Georgia K. Henshaw
Publikováno v:
Drug Metabolism and Disposition. 47:164-172
The antitussive agent noscapine has been shown to inhibit the proliferation of cancer cells by disruption of tubulin dynamic. However, the efficacy of several anticancer drugs that inhibit tublin dynamics (vinca alkaloids and taxanes) is reduced by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e777e8487d0009620b28039c3fce43
https://doi.org/10.1124/dmd.118.083188
https://doi.org/10.1124/dmd.118.083188
Autor:
Luigi Aurelio, Sandeep Chhabra, Meghan Hattarki, Matthew L. Dennis, Bim Graham, James D. Swarbrick, Jonathan B. Baell, Ben Cleary, Jeremy Shonberg, Thomas S. Peat, Nicholas Barlow, Michael D. Lee, Zhong-Chang Wang, Noel P. Pitcher, Jitendra R. Harjani, Aaron DeBono, Olan Dolezal, Raphaël Rahmani, Mohamed H. Ahmed
Publikováno v:
Chemistry - A European Journal. 24:1922-1930
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ef357b708d22a224f1f8f67e14e484
https://doi.org/10.1002/chem.201704730
https://doi.org/10.1002/chem.201704730
Autor:
David A. Jans, Lindsay Lundberg, Kylie M. Wagstaff, Sharon Shechter, David R. Thomas, Kylene Kehn-Hall, Shih-Chao Lin, Chelsea Pinkham, Aaron DeBono
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
Therapeutics are currently unavailable for Venezuelan equine encephalitis virus (VEEV), which elicits flu-like symptoms and encephalitis in humans, with an estimated 14% of cases resulting in neurological disease. Here we identify anti-VEEV agents us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c67e302cf36c6349ef0fa81f062d139
http://link.springer.com/article/10.1038/s41598-017-17672-9
http://link.springer.com/article/10.1038/s41598-017-17672-9
Autor:
Elizabeth A. Vecchio, Lauren T. May, Jonathan B. Baell, Silvia C. Teguh, Guy Y. Krippner, Ryan Brady, Daniel L. Priebbenow, Chengxue Qin, Julia G. Beveridge, Minh Deo, Rebecca H. Ritchie, Girdhar Singh Deora, Aaron DeBono
Publikováno v:
Journal of medicinal chemistry. 62(10)
Herein we describe the development of a focused series of functionalized pyridazin-3(2 H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa513b09b2bac30b32f32192bb26f594
https://pubmed.ncbi.nlm.nih.gov/31038950
https://pubmed.ncbi.nlm.nih.gov/31038950
Autor:
Aaron DeBono, David A. Jans, Lindsay Lundberg, Sharon Shechter, Kylie M. Wagstaff, David R. Thomas, Kylene Kehn-Hall, Shih-Chao Lin, Chelsea Pinkham
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports
Scientific Reports
Therapeutics are currently unavailable for Venezuelan equine encephalitis virus (VEEV), which elicits flu-like symptoms and encephalitis in humans, with an estimated 14% of cases resulting in neurological disease. Here we identify anti-VEEV agents us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03f466246ed1fa11527b3c378d9716a
https://doi.org/10.1038/s41598-018-31644-7
https://doi.org/10.1038/s41598-018-31644-7
Autor:
Aaron DeBono, Christine L. Clarke, Kylene Kehn-Hall, David A. Jans, Lindsay Lundberg, David R. Thomas, Ying Cao, Kylie M. Wagstaff, Sharon Shechter, Chelsea Pinkham, J. Dinny Graham
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
There are currently no therapeutics to treat infection with the alphavirus Venezuelan equine encephalitis virus (VEEV), which causes flu-like symptoms leading to neurological symptoms in up to 14% of cases. Large outbreaks of VEEV can result in 10,00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a565232ea83da96e19c5e808937d233
https://pubmed.ncbi.nlm.nih.gov/30796232
https://pubmed.ncbi.nlm.nih.gov/30796232
Autor:
Chelsea Pinkham, Kylene Kehn-Hall, Caroline A. Hick, David R. Thomas, Jonathan B. Baell, Kylie M. Wagstaff, David A. Jans, Lindsay Lundberg, Sharon Shechter, Aaron DeBono
Publikováno v:
Antiviral research. 151
Although the alphavirus Venezuelan equine encephalitis virus (VEEV) has been the cause of multiple outbreaks resulting in extensive human and equine mortality and morbidity, there are currently no anti-VEEV therapeutics available. VEEV pathogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d02278def3d093123aa91df9438f695
https://pubmed.ncbi.nlm.nih.gov/29337164
https://pubmed.ncbi.nlm.nih.gov/29337164