Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Aaron D. Mickle"'
Autor:
Rosalynn R.Z. Conic, Terrie Vasilopoulos, Karthik Devulapally, Rene Przkora, Andrew Dubin, Kimberly T. Sibille, Aaron D. Mickle
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Urologic chronic pelvic pain syndrome (UCPPS), which includes interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis (CP/CPPS), is associated with increased voiding frequency, nocturia, and chronic pelvic pai
Externí odkaz:
https://doaj.org/article/eefe9ea9b554480fa6ace0e78c830992
Autor:
Olivia J. Yang, Gabriella L. Robilotto, Firoj Alom, Karla Alemán, Karthik Devulapally, Abigail Morris, Aaron D. Mickle
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Gene delivery or manipulation with viral vectors is a frequently used tool in basic neuroscience studies. Adeno-associated viruses (AAV) are the most widely used vectors due to their relative safety and long-term efficacy without causing overt immuno
Externí odkaz:
https://doaj.org/article/32a9766552c34ae8bb7a5fb865a9afce
Publikováno v:
HardwareX, Vol 11, Iss , Pp e00271- (2022)
Studying the visceral sensory component of peripheral nervous systems can be challenging due to limited options for consistent and controlled stimulation. One method for mechanical stimulation of hollow organs, including the colon and bladder, is con
Externí odkaz:
https://doaj.org/article/aa9d64fee3794dfebf18efbc724097f8
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Bone metastasis in breast, prostate and lung cancers often leads to chronic pain, which is poorly managed by existing analgesics. The neurobiological mechanisms that underlie chronic pain associated with bone-metastasized cancers are not well underst
Externí odkaz:
https://doaj.org/article/6931f16dff2f42b9aad839e264211e53
Publikováno v:
Pharmaceuticals, Vol 9, Iss 4, p 72 (2016)
Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-gated ion channels constitute the critical detectors and transducers of pain-causing stimuli. Nociceptive TRP channels are predominantly expressed by distinct
Externí odkaz:
https://doaj.org/article/06fda1e5a00143bab1b32ac22cfc2649
Urothelial cells, which play an essential role in the barrier function, are also thought to play a sensory role in bladder physiology by releasing signaling molecules in response to sensory stimuli that act upon adjacent sensory neurons. However, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c3ce2e5057627e12e7c0cd080d3a48e
https://doi.org/10.1101/2023.02.17.528980
https://doi.org/10.1101/2023.02.17.528980
Publikováno v:
European journal of pain (London, England). 26(9)
Transient receptor potential vanilloid-1 (TRPV1), activated by heat, acidic pH, endogenous vanilloids and capsaicin, is essential for thermal hyperalgesia. Under inflammatory conditions, phosphorylation of TRPV1 by protein kinase C (PKC) can sensitiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2223f764df0cebe5f4217252d73699bd
https://pubmed.ncbi.nlm.nih.gov/35900227
https://pubmed.ncbi.nlm.nih.gov/35900227
Autor:
Seunghwan Min, Yeguang Xue, H. Henry Lai, Vijay K. Samineni, John A. Rogers, Aaron D. Mickle, Yonggang Huang, Jianpeng Zhang, Kaitlyn E. Crawford, Kyung Nim Noh, Maria A. Payne, Lisa A. McIlvried, Paulome Srivastava, Sung Il Park, Hokyung Jang, Kathleen Meacham, Do Hoon Kim, Sang Min Won, Yuhang Li, Young Shiuan, Yeojeong Yun, Jangyeol Yoon, Robert W. Gereau, Bryan A. Copits, Bong Hoon Kim
Publikováno v:
Nature
The fast-growing field of bioelectronic medicine aims to develop engineered systems that can relieve clinical conditions by stimulating the peripheral nervous system1–5. This type of technology relies largely on electrical stimulation to provide ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4e3ccc758d63bad556084de5bbac8d
http://europepmc.org/articles/PMC6336505
http://europepmc.org/articles/PMC6336505
Publikováno v:
HardwareX, Vol 11, Iss, Pp e00271-(2022)
Studying the visceral sensory component of peripheral nervous systems can be challenging due to limited options for consistent and controlled stimulation. One method for mechanical stimulation of hollow organs, including colon and bladder, are contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ede310bf4f8c0f916a96afbaa8dd88
https://doi.org/10.1101/2021.03.15.435466
https://doi.org/10.1101/2021.03.15.435466
Autor:
Theodore J. Price, Yuriy M. Usachev, Robert W. Gereau, Eric G. Krause, Pradipta R. Ray, Lisa A. McIlvried, Tayler D. Sheahan, Simon Haroutounian, Annette D. de Kloet, Bryan A. Copits, Satya Murthy Tadinada, Manouela V. Valtcheva, Suraj Kadunganattil, Páll Karlsson, Gregory Dussor, Aaron D. Mickle, Andrew J. Shepherd, Sanjay Jain, Durga P. Mohapatra
Publikováno v:
Shepherd, A J, Copits, B A, Mickle, A D, Karlsson, P, Kadunganattil, S, Haroutounian, S, Tadinada, S M, de Kloet, A D, Valtcheva, M V, McIlvried, L A, Sheahan, T D, Jain, S, Ray, P R, Usachev, Y M, Dussor, G, Krause, E G, Price, T J, Gereau, R W & Mohapatra, D P 2018, ' Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 38, no. 32, pp. 7032-7057 . https://doi.org/10.1523/JNEUROSCI.3542-17.2018
Injury, inflammation, and nerve damage initiate a wide variety of cellular and molecular processes that culminate in hyperexcitation of sensory nerves, which underlies chronic inflammatory and neuropathic pain. Using behavioral readouts of pain hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514c585ec3dee25328b2548a5aa1347a
https://doi.org/10.1523/jneurosci.3542-17.2018
https://doi.org/10.1523/jneurosci.3542-17.2018