Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Aaron D. Levy"'
Autor:
Aaron D. Levy, Xiao Xiao, Juliana E. Shaw, Suma Priya Sudarsana Devi, Sara Marie Katrancha, Anton M. Bennett, Charles A. Greer, James R. Howe, Kazuya Machida, Anthony J. Koleske
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1523-1535 (2018)
Summary: Hyperactivating mutations in the non-receptor tyrosine phosphatase SHP2 cause Noonan syndrome (NS). NS is associated with cognitive deficits, but how hyperactivation of SHP2 in NS changes neuron function is not well understood. We find that
Externí odkaz:
https://doaj.org/article/2fcf40d6c87c43689141ac463046f066
Autor:
Juliana E. Shaw, Aaron D. Levy, Anthony J. Koleske, Sara Marie Katrancha, Kazuya Machida, Xiao Xiao, Anton M. Bennett, Suma Priya Sudarsana Devi, James R. Howe, Charles A. Greer
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1523-1535 (2018)
Cell reports
Cell reports
In Brief Noonan syndrome (NS) is caused by hyperactive SHP2 and is associated with cognitive deficits. Levy et al. find that NMDA receptor (NMDAR)-mediated currents are disrupted in NS and identify GluN2B Y1252 as a neural substrate of SHP2. Y1252 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512c1e462ad1453864569accdb537471
http://www.sciencedirect.com/science/article/pii/S2211124718310830
http://www.sciencedirect.com/science/article/pii/S2211124718310830
Autor:
TuKiet T. Lam, Richard E. Mains, Megan B. Miller, Aaron D. Levy, Yan Yan, Kazuya Machida, Drew D. Kiraly, Betty A. Eipper, Thomas Abbott, Anthony J. Koleske, Yi I. Wu
Publikováno v:
ACS chemical neuroscience. 8(7)
Kalirin7 (Kal7), a postsynaptic Rho GDP/GTP exchange factor (RhoGEF), plays a crucial role in long term potentiation and in the effects of cocaine on behavior and spine morphology. The KALRN gene has been linked to schizophrenia and other disorders o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e21774578fd22d59054608dcf971660
https://pubmed.ncbi.nlm.nih.gov/28418645
https://pubmed.ncbi.nlm.nih.gov/28418645
Autor:
K. L. Stone, Clare Stokes, Marina R. Picciotto, Aaron D. Levy, Jon Lindstrom, Roger L. Papke, Joel Gelernter, Tristan D. McClure-Begley, Pingxing Xie
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:410-420
Nicotine, the primary psychoactive component in tobacco smoke, produces its behavioral effects through interactions with neuronal nicotinic acetylcholine receptors (nAChRs). α 4 β 2 nAChRs are the most abundant in mammalian brain, and converging ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df10aa204ae6c98da3e737796998333a
https://doi.org/10.1124/jpet.113.209767
https://doi.org/10.1124/jpet.113.209767
Autor:
Michael F. Moran, Ann Marie Pendergast, Anthony J. Koleske, Martin Post, Giulio Superti-Furga, Jeffrey L. Wrana, Jiefei Tong, Jonathan R. Krieger, Yoshinori Matsumoto, Julia Pasquale, Emily Riggs, Marc D. Grynpas, Oliver A. Kent, Mitchell H. Omar, Manuela Ventura, Yaryna Storozhuk, Robert Rottapel, Jose La Rose, Masahiro Narimatsu, Melany J. Wagner, Aaron D. Levy, Behzad Yeganeh
Publikováno v:
The Journal of clinical investigation. 126(12)
Cellular identity in metazoan organisms is frequently established through lineage-specifying transcription factors, which control their own expression through transcriptional positive feedback, while antagonizing the developmental networks of competi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ca318915c71c75e8c9e8076e15a5bf
https://pubmed.ncbi.nlm.nih.gov/27797343
https://pubmed.ncbi.nlm.nih.gov/27797343
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(25)
Immature glutamatergic synapses in cultured neurons contain high-release probability (Pr) presynaptic sites coupled to postsynaptic sites bearing GluN2B-containing NMDA receptors (NMDARs), which mature into low-Pr, GluN2B-deficient synapses. Whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d88a4992970283333a7e86815bce6be
https://pubmed.ncbi.nlm.nih.gov/27335408
https://pubmed.ncbi.nlm.nih.gov/27335408
Publikováno v:
Frontiers in Neuroanatomy
Frontiers in Neuroanatomy, Vol 8 (2014)
Frontiers in Neuroanatomy, Vol 8 (2014)
Dendritic spines are the receptive contacts at most excitatory synapses in the central nervous system. Spines are dynamic in the developing brain, changing shape as they mature as well as appearing and disappearing as they make and break connections.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d0509c71f7ee9413d9c66ccea18b74
http://europepmc.org/articles/PMC4202714
http://europepmc.org/articles/PMC4202714
Autor:
Aaron D. Levy, Anne E. Luebke, Ania K. Majewska, Paul D. Allen, L. J. Bogart, Martha L. Zettel, James R. Ison, M. Gladstone
Publikováno v:
Neural Plasticity
Neural Plasticity, Vol 2011 (2011)
Neural Plasticity, Vol 2011 (2011)
Disturbance of sensory input during development can have disastrous effects on the development of sensory cortical areas. To examine how moderate perturbations of hearing can impact the development of primary auditory cortex, we examined markers of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bff85f53ba7f29612cd440e08ac6d20