Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aaron D. Cabral"'
Autor:
Nabanita Nawar, Shazreh Bukhari, Ashley A. Adile, Yujin Suk, Pimyupa Manaswiyoungkul, Krimo Toutah, Olasunkanmi O. Olaoye, Yasir S. Raouf, Abootaleb Sedighi, Harsimran Kaur Garcha, Muhammad Murtaza Hassan, William Gwynne, Johan Israelian, Tudor B. Radu, Mulu Geletu, Ayah Abdeldayem, Justyna M. Gawel, Aaron D. Cabral, Chitra Venugopal, Elvin D. de Araujo, Sheila K. Singh, Patrick T. Gunning
Publikováno v:
Journal of Medicinal Chemistry. 65:3193-3217
Publikováno v:
RSC Chemical Biology
Proximal multi-site phosphorylation is a critical post-translational modification in protein biology. The additive effects of multiple phosphosite clusters in close spatial proximity triggers integrative and cooperative effects on protein conformatio
Autor:
Nabanita, Nawar, Shazreh, Bukhari, Ashley A, Adile, Yujin, Suk, Pimyupa, Manaswiyoungkul, Krimo, Toutah, Olasunkanmi O, Olaoye, Yasir S, Raouf, Abootaleb, Sedighi, Harsimran Kaur, Garcha, Muhammad Murtaza, Hassan, William, Gwynne, Johan, Israelian, Tudor B, Radu, Mulu, Geletu, Ayah, Abdeldayem, Justyna M, Gawel, Aaron D, Cabral, Chitra, Venugopal, Elvin D, de Araujo, Sheila K, Singh, Patrick T, Gunning
Publikováno v:
Journal of medicinal chemistry. 65(4)
Histone deacetylase 6 (HDAC6) has been targeted in clinical studies for anticancer effects due to its role in oncogenic transformation and metastasis. Through a second-generation structure-activity relationship (SAR) study, the design, and biological
Autor:
Aaron D. Cabral, Daniel Nino, Nafiseh Rafiei, Krimo Toutah, Patrick T. Gunning, Tudor B. Radu, Elvin D. de Araujo, Bronte I. Murcar-Evans, Joshua N. Milstein, Dziyana Kraskouskaya
Publikováno v:
ACS Sensors. 5:2753-2762
Antibiotic resistance is a major problem for world health, triggered by the unnecessary usage of broad-spectrum antibiotics on purportedly infected patients. Current clinical standards require lengthy protocols for the detection of bacterial species
Autor:
Andrew E. Shouksmith, Abootaleb Sedighi, Yasir S. Raouf, Niyati Kachhiyapatel, Ayah Abdeldayem, Paris R. Watson, Krimo Toutah, Olasunkanmi O. Olaoye, David W. Christianson, Patrick T. Gunning, Shazreh Bukhari, Pimyupa Manaswiyoungkul, Justyna M. Gawel, Aaron D. Cabral, Johan Israelian, Muhammad Murtaza Hassan, Nabanita Nawar, Fettah Erdogan, Elvin D. de Araujo, Tudor B. Radu, Mulu Geletu
Publikováno v:
J Med Chem
Histone deacetylase 6 (HDAC6) is involved in multiple regulatory processes, ranging from cellular stress to intracellular transport. Inhibition of aberrant HDAC6 activity in several cancers and neurological diseases has been shown to be efficacious i
Autor:
Muhammad Murtaza Hassan, Yasir S. Raouf, Pimyupa Manaswiyoungkul, Aaron D. Cabral, Abootaleb Sedighi, Rabia Altintas, Fettah Erdogan, Patrick T. Gunning, Giovanni Ganda, David W.J. Armstrong, Olasunkanmi O. Olaoye, Elvin D. de Araujo, Johan Israelian, Fabrizio Angeles, Nabanita Nawar
Publikováno v:
Journal of medicinal chemistry. 63(15)
Histone deacetylases (HDACs) are an attractive therapeutic target for a variety of human diseases. Currently, all four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, exhibiting adverse side effects at therapeutic doses. Alth
Autor:
Abootaleb Sedighi, Yasir S. Raouf, Diana Sina, Krimo Toutah, Johan Israelian, Andrew E. Shouksmith, Patrick T. Gunning, Shazreh Bukhari, Elvin D. de Araujo, Olasunkanmi O. Olaoye, Aaron D. Cabral, Nabanita Nawar, Tudor B. Radu, Justyna M. Gawel, Pimyupa Manaswiyoungkul
Publikováno v:
European journal of medicinal chemistry. 201
Dysregulated Histone Deacetylase (HDAC) activity across multiple human pathologies have highlighted this family of epigenetic enzymes as critical druggable targets, amenable to small molecule intervention. While efficacious, current approaches using
Autor:
Elvin D. de Araujo, Andrew E. Shouksmith, Abootaleb Sedighi, Aaron D. Cabral, Patrick T. Gunning, Pimyupa Manaswiyoungkul, Diana Sina, Shazreh Bukhari, Yasir S. Raouf, Justyna M. Gawel, Liying He, Alexandra E. Johns, Nabanita Nawar, Olasunkanmi O. Olaoye
Publikováno v:
ACS Med Chem Lett
[Image: see text] The HDAC inhibitor 4-tert-butyl-N-(4-(hydroxycarbamoyl)phenyl)benzamide (AES-350, 51) was identified as a promising preclinical candidate for the treatment of acute myeloid leukemia (AML), an aggressive malignancy with a meagre 24%
Autor:
Fettah Erdogan, Aaron D. Cabral, Patrick T. Gunning, Elvin D. de Araujo, Pimyupa Manaswiyoungkul, Olasunkanmi O. Olaoye
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 184
Signal transducer and activator of transcription 5B (STAT5B) is constitutively activated in multiple cancers as a result of hyperactivating mutations or dysregulation of upstream effectors. Therapeutic strategies have predominantly targeted the Src h
Autor:
Angelika Berger-Becvar, Elvin D. de Araujo, Angel Lai, Bronte I. Murcar-Evans, Krimo Toutah, Dziyana Kraskouskaya, Patrick T. Gunning, Aaron D. Cabral, Peter M. Macdonald
Publikováno v:
The Analyst. 142(23)
Membrane-embedded negatively charged phospholipids (MENCP) can be used as biomarkers for a range of biological processes, including early detection of apoptosis in animal cells, drug-induced phospholipidosis, and selective detection of bacterial over