Výsledky vyhledávání - "Aaron D Loewen"

Akademický článek

CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance

Autor: Troy A. McDiarmid, Vinci Au, Aaron D. Loewen, Joseph Liang, Kota Mizumoto, Donald G. Moerman, Catharine H. Rankin

Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 12 (2018)

Our ability to sequence genomes has vastly surpassed our ability to interpret the genetic variation we discover. This presents a major challenge in the clinical setting, where the recent application of whole-exome and whole-genome sequencing has unco

Externí odkaz: https://doaj.org/article/4d19cfd57e27424a95ab8cf6388ff215

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Autophagy Induction by HDAC Inhibitors Is Unlikely to be the Mechanism of Efficacy in Prevention of Retinal Degeneration Caused by P23H Rhodopsin

Autor: Runxia H, Wen, Aaron D, Loewen, Ruanne Y J, Vent-Schmidt, Orson L, Moritz

Publikováno v: Advances in experimental medicine and biology. 1185

We previously found that valproic acid (VPA) and other histone deacetylase inhibitors (HDACis) ameliorate retinal degeneration (RD) caused by P23H rhodopsin in Xenopus laevis larvae and hypothesized that this may be due to enhancement of autophagy. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ea4d4f9b964ef110aab01012c21a572
https://pubmed.ncbi.nlm.nih.gov/31884645

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Autophagy Induction by HDAC Inhibitors Is Unlikely to be the Mechanism of Efficacy in Prevention of Retinal Degeneration Caused by P23H Rhodopsin

Autor: Orson L. Moritz, Ruanne Y.J. Vent-Schmidt, Aaron D Loewen, Runxia H. Wen

Publikováno v: Retinal Degenerative Diseases ISBN: 9783030273774

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76afaa91ea984f86262b4b4665c1b907
https://doi.org/10.1007/978-3-030-27378-1_66

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CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance

Autor: Joseph Liang, Kota Mizumoto, Catharine H. Rankin, Donald G. Moerman, Aaron D Loewen, Vinci Au, Troy A. McDiarmid

Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 12 (2018)
Disease Models & Mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45452ac01b1785e577195101d90aae24
http://dmm.biologists.org/content/11/12/dmm036517

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