A novel method for quantifying axon degeneration.

Autor: Aaron D Johnstone, Robin M Hallett, Andrés de Léon, Bruno Carturan, Julien Gibon, Philip A Barker

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0199570 (2018)

Axons normally degenerate during development of the mammalian nervous system, but dysregulation of the same genetically-encoded destructive cellular machinery can destroy crucial structures during adult neurodegenerative diseases. Nerve growth factor

Externí odkaz: https://doaj.org/article/6268038ca52446609ffc32b01461f43d

Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy

Autor: Bradley Kievit, Aaron D. Johnstone, Julien Gibon, Philip A. Barker

Publikováno v: Frontiers in molecular neuroscience. 15

Axons that are physically separated from their soma activate a series of signaling events that results in axonal self-destruction. A critical element of this signaling pathway is an intra-axonal calcium rise that occurs just prior to axonal fragmenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bce5f919e91686803d43c67d4d0f2d
https://pubmed.ncbi.nlm.nih.gov/35370552

Developmental Axon Degeneration Requires TRPV1-Dependent Ca

Autor: Aaron D, Johnstone, Andrés, de Léon, Nicolás, Unsain, Julien, Gibon, Philip A, Barker

Publikováno v: eNeuro

Visual Abstract
Development of the nervous system relies on a balance between axon and dendrite growth and subsequent pruning and degeneration. The developmental degeneration of dorsal root ganglion (DRG) sensory axons has been well studied in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14df96e6394e52a28b7909b81e341a04
https://pubmed.ncbi.nlm.nih.gov/30838324

Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration

Autor: Fernando D. Stefani, Catalina von Bilderling, Nicolas Unsain, Mariano Bisbal, Martín Diego Bordenave, Gaby F. Martinez, Sami Jalil, Alfredo Cáceres, Philip A. Barker, Federico Martín Barabas, Luciano A. Masullo, Aaron D. Johnstone

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports

Axonal degeneration occurs in the developing nervous system for the appropriate establishment of mature circuits, and is also a hallmark of diverse neurodegenerative diseases. Despite recent interest in the field, little is known about the changes (a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f212af994d2241c630ac0d00f9042094
https://www.nature.com/articles/s41598-018-21232-0

Sildenafil Improves Brain Injury Recovery following Term Neonatal Hypoxia-Ischemia in Male Rat Pups

Autor: Armin Yazdani, Zehra Khoja, Pia Wintermark, Emmanouil Rampakakis, Laura M. Dale, Aaron D. Johnstone

Publikováno v: Developmental Neuroscience. 38:251-263

Term asphyxiated newborns remain at risk of developing brain injury despite available neuropreventive therapies such as hypothermia. Neurorestorative treatments may be an alternative. This study investigated the effect of sildenafil on brain injury i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57369d39702a79fa1362527679e8dc1
https://doi.org/10.1159/000448327