Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Aaron D, Krabill"'
Autor:
Aaron D. Krabill, Hao Chen, Sajjad Hussain, Chad S. Hewitt, Ryan D. Imhoff, Christine S. Muli, Chittaranjan Das, Paul J. Galardy, Michael K. Wendt, Daniel P. Flaherty
Publikováno v:
Molecules, Vol 26, Iss 5, p 1227 (2021)
The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of quality probe molecules to gain a better understanding on UCHL1 biology. To this end a study w
Externí odkaz:
https://doaj.org/article/61cafbcea7ac477da7a719f874ab958a
Autor:
Amanda L. Graboski, Xufeng Cao, Yehia Elgammal, Devon P. Amos, Molly S. Youse, Alessio Nocentini, Nader S. Abutaleb, Anil Kumar Marapaka, Weiwei An, Mohamed N. Seleem, Claudiu T. Supuran, Ahmed E. M. Elhassanny, Katrina J. Holly, Chad S. Hewitt, Daniel P. Flaherty, Jatinder Kaur, Aaron D Krabill, Ahmed Elkashif
Publikováno v:
ACS Infectious Diseases. 7:1969-1984
Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased rates of resistance. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::506c99f38b00123de518cee832d6beb7
https://doi.org/10.1021/acsinfecdis.1c00055
https://doi.org/10.1021/acsinfecdis.1c00055
Publikováno v:
Biochemistry. 59:3447-3462
Ubiquitin (Ub) is a highly conserved protein that is covalently attached to substrate proteins as a post-translational modification to regulate signaling pathways such as proteasomal degradation and cell cycle/transcriptional regulation in the eukary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9f41cc7584c01b8dc249f24b3e0698
https://doi.org/10.1021/acs.biochem.9b01076
https://doi.org/10.1021/acs.biochem.9b01076
Autor:
Paul J. Galardy, Michael K. Wendt, Chao Feng, Hao Chen, Chittaranjan Das, Ammara Abdullah, Carol Beth Post, Sajjad Hussain, Uma K. Aryal, Daniel P. Flaherty, Aaron D Krabill
Publikováno v:
ChemBioChem. 21:712-722
The deubiquitinase (DUB) ubiquitin C-terminal hydrolase L1 (UCHL1) is expressed primarily in the central nervous system under normal physiological conditions. However, UCHL1 is overexpressed in various aggressive forms of cancer with strong evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0516ea67cb642242b5f52d3a4b3e94
https://doi.org/10.1002/cbic.201900434
https://doi.org/10.1002/cbic.201900434
Autor:
Aaron D Krabill, Zhong Yin Zhang
Publikováno v:
Biochem Soc Trans
Protein tyrosine phosphatases (PTPs) counteract the enzymatic activity of protein tyrosine kinases to modulate levels of both normal and disease-associated protein tyrosine phosphorylation. Aberrant activity of PTPs has been linked to the progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f8855b2de6fbafe4ce4efc75b01857
https://pubmed.ncbi.nlm.nih.gov/34431504
https://pubmed.ncbi.nlm.nih.gov/34431504
Autor:
Chad S, Hewitt, Nader S, Abutaleb, Ahmed E M, Elhassanny, Alessio, Nocentini, Xufeng, Cao, Devon P, Amos, Molly S, Youse, Katrina J, Holly, Anil Kumar, Marapaka, Weiwei, An, Jatinder, Kaur, Aaron D, Krabill, Ahmed, Elkashif, Yehia, Elgammal, Amanda L, Graboski, Claudiu T, Supuran, Mohamed N, Seleem, Daniel P, Flaherty
Publikováno v:
ACS Infect Dis
Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased rates of resistance. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::276a76d58342871c1deb2f7fde0604e6
https://pubmed.ncbi.nlm.nih.gov/33765392
https://pubmed.ncbi.nlm.nih.gov/33765392
Autor:
Ryan D Imhoff, Aaron D Krabill, Chad S. Hewitt, Daniel P. Flaherty, Christine S Muli, Paul J. Galardy, Hao Chen, Sajjad Hussain, Chittaranjan Das, Michael K. Wendt
Publikováno v:
Molecules
Volume 26
Issue 5
Molecules, Vol 26, Iss 1227, p 1227 (2021)
Volume 26
Issue 5
Molecules, Vol 26, Iss 1227, p 1227 (2021)
The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of quality probe molecules to gain a better understanding on UCHL1 biology. To this end a study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c208f912b6b055b9d901bb24673e3fb2
Autor:
Aaron D. Krabill, Hao Chen, Sajjad Hussain, Chao Feng, Ammara Abdullah, Chad S. Hewitt, Chittaranjan Das, Uma K. Aryal, Carol Beth Post, Michael K. Wendt, Paul J. Galardy, Daniel P. Flaherty
Publikováno v:
Chembiochem
The deubiquitinase (DUB) Ubiquitin C-terminal Hydrolase L1 (UCHL1) is expressed primarily in the central nervous system under normal physiological conditions. However, UCHL1 is overexpressed in various aggressive forms of cancer with strong evidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19b143ce3b86bb140255d4db6cfc310
https://pubmed.ncbi.nlm.nih.gov/31449350
https://pubmed.ncbi.nlm.nih.gov/31449350
Autor:
Jatinder, Kaur, Xufeng, Cao, Nader S, Abutaleb, Ahmed, Elkashif, Amanda L, Graboski, Aaron D, Krabill, Ahmed Hassan, AbdelKhalek, Weiwei, An, Atul, Bhardwaj, Mohamed N, Seleem, Daniel P, Flaherty
Publikováno v:
J Med Chem
Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired infections (HAIs) attributed to a drug-resistant bacterium in the United States and resistance to the frontline treatments is well documented. To combat VRE, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd1ac8909c7435d76228bb74bba6f1b6
https://pubmed.ncbi.nlm.nih.gov/32787141
https://pubmed.ncbi.nlm.nih.gov/32787141