Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Aaron Ciechanover"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Huntington’s disease (HD) is caused by a glutamine repeat expansion in the protein huntingtin. Mutated huntingtin (mHtt) forms aggregates whose impacts on neuronal survival are still debated. Using weeks-long, continual imaging of cortical
Externí odkaz:
https://doaj.org/article/570f213c91c048b794109a5e6f03ad9f
Autor:
Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky, Aaron Ciechanover
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiquitination-promoting complex su
Externí odkaz:
https://doaj.org/article/918e4432e5634576bba28c5195a42d9f
Autor:
Shunit Neeman-Egozi, Ido Livneh, Irit Dolgopyat, Udi Nussinovitch, Helena Milman, Nadav Cohen, Binyamin Eisen, Aaron Ciechanover, Ofer Binah
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4932 (2024)
The ubiquitin–proteasome system (UPS) is an essential mechanism responsible for the selective degradation of substrate proteins via their conjugation with ubiquitin. Since cardiomyocytes have very limited self-renewal capacity, as they are prone to
Externí odkaz:
https://doaj.org/article/3b1ff9ecfa7d43ff81bb3fabd8fc1e91
Publikováno v:
Rambam Maimonides Medical Journal, Vol 14, Iss 4, p e0019 (2023)
It has been the policy of Rambam Maimonides Medical Journal to limit the number of editorials published. However, silence and standing on the sidelines is not an option in light of the atrocities and inhumanity we witnessed on October 7. The savagery
Externí odkaz:
https://doaj.org/article/f3292ed989654987b0dad9254dd5e2ba
Publikováno v:
Cells, Vol 13, Iss 2, p 180 (2024)
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes responsible for linking a transfer RNA (tRNA) with its cognate amino acid present in all the kingdoms of life. Besides their aminoacyl-tRNA synthetase activity, it was described that many of th
Externí odkaz:
https://doaj.org/article/8292f8df401e4660891064cebf465127
Autor:
Ortal Nahum-Ankonina, Efrat Kurtzwald-Josefson, Aaron Ciechanover, Maayan Waldman, Orna Shwartz-Rohaker, Edith Hochhauser, Sam J. Meyer, Dan Aravot, Moshe Phillip, Yaron D. Barac
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15376 (2023)
This study investigated modifications to the ubiquitin proteasome system (UPS) in a mouse model of type 2 diabetes mellitus (T2DM) and their relationship to heart complications. db/db mice heart tissues were compared with WT mice tissues using RNA se
Externí odkaz:
https://doaj.org/article/24c98cc1597b4f5d8e699aa5bfe18cdd
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2021)
Abstract Background Hematopoietic stem cell (HSC) transplantation is an effective treatment strategy for many types of diseases. Peripheral blood (PB) is the most commonly used source of bone marrow (BM)-derived stem cells for current HSC transplanta
Externí odkaz:
https://doaj.org/article/c71f7b36bf7544b682ceadeb4dd95fbb
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 5 (2021)
Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes. Whether they are real has become the center of heated discussion where the main issues are their mech
Externí odkaz:
https://doaj.org/article/f263ab72044f4461afd1ed2dba582776
Autor:
Bert M. Verheijen, Aaron Ciechanover
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/f263d679e17a4d8b9816b24f3d5ece19
Autor:
Hyunjoo Cha-Molstad, Ji Eun Yu, Zhiwei Feng, Su Hyun Lee, Jung Gi Kim, Peng Yang, Bitnara Han, Ki Woon Sung, Young Dong Yoo, Joonsung Hwang, Terry McGuire, Sang Mi Shim, Hyun Dong Song, Srinivasrao Ganipisetti, Nuozhou Wang, Jun Min Jang, Min Jae Lee, Seung Jun Kim, Kyung Ho Lee, Jin Tae Hong, Aaron Ciechanover, Inhee Mook-Jung, Kwang Pyo Kim, Xiang-Qun Xie, Yong Tae Kwon, Bo Yeon Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin
Externí odkaz:
https://doaj.org/article/a427518b7ba242ffb3606852a4c4bba9