INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants

Autor: Viviane M. Andrade, Aaron Christensen-Quick, Joseph Agnes, Jared Tur, Charles Reed, Richa Kalia, Idania Marrero, Dustin Elwood, Katherine Schultheis, Mansi Purwar, Emma Reuschel, Trevor McMullan, Patrick Pezzoli, Kim Kraynyak, Albert Sylvester, Mammen P. Mammen, Pablo Tebas, J. Joseph Kim, David B. Weiner, Trevor R. F. Smith, Stephanie J. Ramos, Laurent M. Humeau, Jean D. Boyer, Kate E. Broderick

Publikováno v: npj Vaccines, Vol 6, Iss 1, Pp 1-4 (2021)

Abstract Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses again

Externí odkaz: https://doaj.org/article/861f6b3de24f4eca965d9adae892bcdd

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

Autor: Pablo Tebas, ShuPing Yang, Jean D. Boyer, Emma L. Reuschel, Ami Patel, Aaron Christensen-Quick, Viviane M. Andrade, Matthew P. Morrow, Kimberly Kraynyak, Joseph Agnes, Mansi Purwar, Albert Sylvester, Jan Pawlicki, Elisabeth Gillespie, Igor Maricic, Faraz I. Zaidi, Kevin Y. Kim, Yaya Dia, Drew Frase, Patrick Pezzoli, Katherine Schultheis, Trevor R.F. Smith, Stephanie J. Ramos, Trevor McMullan, Karen Buttigieg, Miles W. Carroll, John Ervin, Malissa C. Diehl, Elliott Blackwood, Mammen P. Mammen, Jessica Lee, Michael J. Dallas, Ami Shah Brown, Jacqueline E. Shea, J.Joseph Kim, David B. Weiner, Kate E. Broderick, Laurent M. Humeau

Publikováno v: EClinicalMedicine, Vol 31, Iss , Pp 100689- (2021)

Background: A vaccine against SARS-CoV-2 is of high urgency. Here the safety and immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen of SARS-CoV-2 are described. Methods: INO-4800 was evaluated in two groups of

Externí odkaz: https://doaj.org/article/a9f1cb97a12243469984e15dede48ebe

Seeking career clarity

Autor: Yongsheng Ji, Athanasia Nikolaou, Pragya Srivastava, Khor Waiho, Samuel Nathan Kirshner, Brynn Anne Hollingsworth, Michael J. Strong, Muhammad M. Khalifa, Aaron Christensen-Quick, Antarip Halder, Aleksandra Kosanic, Nikos Konstantinides, Norman van Rhijn, Katie Burnette, Ashley B. Heim, Chloe Antoniou, Eric Britt Moore, Monika Lewinska, Saumya Saurabh

Publikováno v: Van Rhijn, N, Antoniou, C, Burnette, K, Christensen-Quick, A, Lewinska, M, Ji, Y, Khalifa, M, Nikolaou, A, Srivastava, P, Hollingsworth, B, Sarah, S, Konstantinides, N, Heim, A, Moore, E, Strong, M, Kosanic, A, Kirshner, S, Halder, A & Wait, K 2020, ' Seeking career clarity ', Science, vol. 368, no. 6486, 10.1126/science.abb6859, pp. 26-28 . https://doi.org/10.1126/science.abb6859

We asked young scientists to serve as peer mentors for “Seeking Career Clarity,” the author of the question below. By asking refl ective questions, sharing relevant personal experiences, and of ering advice, these scientists provide support and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b3c5bfa505787e6b151e0e199495a7
https://doi.org/10.1126/science.abb6859

INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T cell Activity Against Global SARS-CoV-2 Variants

Autor: Joseph Agnes, Aaron Christensen-Quick, Emma L. Reuschel, Kim Kraynyak, Jared Tur, Mammen P Mammen, Viviane M Andrade, Trevor R.F. Smith, Katherine Schultheis, Dustin Elwood, Patrick Pezzoli, Jean D. Boyer, Idania Marrero, Laurent Humeau, Stephanie Ramos, David B. Weiner, J. Joseph Kim, Trevor McMullan, Albert Sylvester, Pablo Tebas, Charles C. Reed, Kate E. Broderick, Mansi Purwar, Richa Kalia

Publikováno v: npj Vaccines, Vol 6, Iss 1, Pp 1-4 (2021)
NPJ Vaccines

Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99099b9b80749aac455ddd7326015284
https://doi.org/10.1101/2021.04.14.439719

Influenza Vaccination Can Broadly Activate the HIV Reservoir During Antiretroviral Therapy

Autor: Sara Gianella, Antoine Chaillon, Caroline Ignacio, Aaron Christensen-Quick, Parris Jordan, Davey M. Smith, Gemma Caballero, Christina Yek, Fabio Zanini

Publikováno v: Journal of acquired immune deficiency syndromes (1999), vol 79, iss 3
Christensen-Quick, Aaron; Chaillon, Antoine; Yek, Christina; Zanini, Fabio; Jordan, Parris; Ignacio, Caroline; et al.(2018). Influenza Vaccination Can Broadly Activate the HIV Reservoir During Antiretroviral Therapy.. Journal of acquired immune deficiency syndromes (1999), 79(3), e104-e107. doi: 10.1097/qai.0000000000001829. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/4079w4c3

Author(s): Christensen-Quick, Aaron; Chaillon, Antoine; Yek, Christina; Zanini, Fabio; Jordan, Parris; Ignacio, Caroline; Caballero, Gemma; Gianella, Sara; Smith, Davey

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781e40753fa8ca17126b3889be07958b
https://doi.org/10.1097/qai.0000000000001829