Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aaron Castro"'
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147234 (2016)
Modified nucleosides have the potential to inhibit DNA polymerases for the treatment of viral infections and cancer. With the hope of developing potent drug candidates by the modification of the 2',4'-position of the ribose with the inclusion of a br
Externí odkaz:
https://doaj.org/article/8adbc535efcd4ca28cfe5f04a54c4359
Autor:
Jose Manuel Nieto Jalil, Aaron Castro Bazua, Luis Carlos Felix Herran, Francisco Isaias Gutierrez Castillo, Dionisio Othon Katase, Oscar Alberto Gonzalez Valenzuela
Publikováno v:
2022 IEEE Global Engineering Education Conference (EDUCON).
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147234 (2016)
PLoS ONE
PLoS ONE
Modified nucleosides have the potential to inhibit DNA polymerases for the treatment of viral infections and cancer. With the hope of developing potent drug candidates by the modification of the 2’,4’-position of the ribose with the inclusion of
Autor:
Aaron Castro, Pavlo Holenya, Maren Eckey, Marco Schulz, Holger Wenschuh, Ulf Reimer, Tatjana Tech, Kam Chan, Ramesh Janani, Blake Broaten, Florian Kern
Publikováno v:
The Journal of Immunology. 200:120.15-120.15
T-cell activation assays such as Elispot or Intracellular Cytokine Staining (ICS) require appropriate positive stimulation controls. Compared with conventional assay controls based on polyclonal stimulation (e.g. PHA/Ionomycin), peptide pools have th
Autor:
Aaron Castro, Evelyna Derhovanessian, Ulrich Luxemburger, Michaela Beck, Franziska Gehring, Holger Wenschuh, Johannes Zerweck, Florian Kern, Ulf Reimer, Ugur Sahin
Publikováno v:
The Journal of Immunology. 198:213.5-213.5
Advances in genomic technologies have paved the way to developing personalized cancer vaccines targeting neo-antigens. Patient-specific vaccines, targeting several neo-antigens in one go have already entered the clinic. Such personalized, multi-targe
Publikováno v:
The Journal of Immunology. 162:1261-1269
IL-2 activates several distinct signaling pathways that are important for T cell activation, proliferation, and differentiation into both Th1 and Th2 phenotypes. IL-4, the major cytokine that promotes differentiation of Th2 cells, has been shown to b
Autor:
Yuewei Zhao, Austin Dinkel, Xiaoyun Liu, Miguel E. Castro, Houquan Dai, Sung Kun Kim, Aaron Castro, Leticia Loredo
Publikováno v:
Cancer Research. 76:411-411
BRAF is a human gene encoding a serine/threonine protein kinase in the RAS-RAF-MEK-ERK signal pathway, which is important in regulating cellular responses to extracellular signals. Frequent mutations on BRAF gene have been detected in various types o
Publikováno v:
Journal of Leukocyte Biology. 50:615-623
Recent studies by these investigators have shown that horseradish peroxidase (HRP) can cause murine thioglycollate-induced peritoneal macrophages (Mø) to produce both tumor necrosis factor (TNF) and enhance macrophage-mediated cytotoxicity (MMC) to
Publikováno v:
Cancer Research. 75:4753-4753
Mutations on epidermal growth factor receptor (EGFR) cause a variety of cancers including breast and lung cancers. The single mutation T790M on tyrosine kinase domain of EGFR signifies the response to the popular cancer drug gefitinib, which leads to
Autor:
Aaron Castro, Kathryn Stephenson, George Neubauer, Bette Korber, Dan Barouch, Nikolaus Pawlowski, Johannes Zerweck, Ulf Reimer
Publikováno v:
The Journal of Immunology. 194:206.21-206.21
Pathogens such as HIV or other viruses exhibit considerable sequence diversity as a strategy to escape the host immune system. However, sequence diversity is not limited to infectious agents. The increasing application of DNA sequencing indicates div