Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Aaron C. Koppel"'
1
Genetic algorithm-based personalized models of human cardiac action potential
Autor: Kedar Aras, R. A. Syunyaev, Ruslan Deviatiiarov, Igor R. Efimov, Dmitrii Smirnov, Oleg Gusev, Andrey Pikunov, Anna Gams, Aaron C. Koppel
Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0231695 (2020)
We present a novel modification of genetic algorithm (GA) which determines personalized parameters of cardiomyocyte electrophysiology model based on set of experimental human action potential (AP) recorded at different heart rates. In order to find t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf76d2753c3da0d17d0a3340f042b29
http://europepmc.org/articles/PMC7213718
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2
Genetic algorithm-based personalized models of human cardiac action potential
Autor: Aaron C. Koppel, Oleg Gusev, Ruslan Deviatiiarov, Dmitrii Smirnov, R. A. Syunyaev, Igor R. Efimov, Kedar Aras
We present a novel genetic algorithm-based solution to determine the set of cardiomyocyte model parameters based on experimental human action potential (AP) recordings. The novel approach is based on AP waveform dependence on the heart rate. In order
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f404756ab54f7eb3bcdbf237994753
https://doi.org/10.1101/712406
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3
Cell Type-Specific p38δ Targeting Reveals a Context-, Stage-, and Sex-Dependent Regulation of Skin Carcinogenesis
Autor: Meral Barlas, Alexi Kiss, Maxwell Sall, Grace E. Kissling, Emily C. Murphy, Tatiana Efimova, Aaron C. Koppel
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1532 (2019)
Volume 20
Issue 7
Activation and/or upregulated expression of p38&delta
are demonstrated in human skin malignancies including cutaneous squamous cell carcinoma, suggesting a role for p38&delta
in skin carcinogenesis. We previously reported that mice with ger
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d95ea5e0f9f0fbfd2fc995c1b8d1945
https://pubmed.ncbi.nlm.nih.gov/30934690
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4
Arrhythmogenic and metabolic remodelling of failing human heart
Autor: Christopher R Gloschat, Aaron C. Koppel, Kedar Aras, Jaclyn A. Brennan, Igor R. Efimov, Katherine M. Holzem
Publikováno v: The Journal of Physiology. 594:3963-3980
Heart failure (HF) is a major cause of morbidity and mortality worldwide. The global burden of HF continues to rise, with prevalence rates estimated at 1-2% and incidence approaching 5-10 per 1000 persons annually. The complex pathophysiology of HF i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1f0dce07571dd0264bb24d7903cd4be
https://doi.org/10.1113/jp271992
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6
Keratinocyte p38δ loss inhibits Ras-induced tumor formation, while systemic p38δ loss enhances skin inflammation in the early phase of chemical carcinogenesis in mouse skin
Autor: Alexi Kiss, Christophe Cataisson, Stuart H. Yuspa, Miroslav Blumenberg, Tatiana Efimova, Joanna Anders, Aaron C. Koppel
Publikováno v: Molecular Carcinogenesis. 55:563-574
p38δ expression and/or activity are increased in human cutaneous malignancies, including invasive squamous cell carcinoma (SCC) and head and neck SCC, but the role of p38δ in cutaneous carcinogenesis has not been well-defined. We have reported that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df9ec3f32cb8552e6cca044ae9093e43
https://doi.org/10.1002/mc.22303
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7
Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice
Autor: Anna Hindes, Carole J. Burns, Alexi Kiss, Gregory I. Goldberg, Miroslav Blumenberg, Barry L. Marmer, Tatiana Efimova, Aaron C. Koppel
Publikováno v: American Journal of Physiology-Cell Physiology. 306:C899-C909
Proline-rich protein tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family. We used Pyk2 knockout (Pyk2-KO) mice to study the role of Pyk2 in cutaneous wound repair. We report that the rate of wound closure was delayed in Pyk2-KO c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9044ba390a924aacc2356a8cce0b176
https://doi.org/10.1152/ajpcell.00331.2013
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9
Serum Response Factor Controls Transcriptional Network Regulating Epidermal Function and Hair Follicle Morphogenesis
Autor: Anna Hindes, Miroslav Blumenberg, Seth D. Crosby, Alexi Kiss, Narendrakumar Ramanan, Frode L. Jahnsen, Carole J. Burns, Tatiana Efimova, Liang Ma, Denis Khnykin, Yan Yin, Aaron C. Koppel, Congxing Lin
Publikováno v: Journal of Investigative Dermatology. 133(3):608-617
Serum response factor (SRF) is a transcription factor that regulates the expression of growth-related immediate-early, cytoskeletal, and muscle-specific genes to control growth, differentiation, and cytoskeletal integrity in different cell types. To
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a313fa0e61e0533f5ec97a18ccd5da
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10
Reduced response to IKr blockade and altered hERG1a/1b stoichiometryin human heart failure
Autor: Alexey V. Glukhov, Eli J. Madden, Igor R. Efimov, Beatriz Trenor, Katherine M. Holzem, Juan F. Gomez, Gregory A. Ewald, Aaron C. Koppel
Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
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Heart failure (HF) claims 250,000 lives per year in the US, and nearly half of these deaths are sudden and presumably due to ventricular tachyarrhythmias. QT interval and action potential (AP) prolongation are hallmark proarrhythmic changes in the fa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba2fc60178e10839864d2423c600062
http://hdl.handle.net/10251/83828
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