Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Aaron C. Hirko"'
Publikováno v:
Toxicology Letters. 299:47-55
Environmental exposure to the highly persistent chlorinated pesticides including dieldrin and lindane is postulated to be a risk factor to the development of Parkinson’s disease, a devastating movement disorder. We have previously reported that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c3e2a1a9bd5aea4fe5145008e7f3a6
https://doi.org/10.1016/j.toxlet.2018.09.006
https://doi.org/10.1016/j.toxlet.2018.09.006
Autor:
Jeffrey S. Thinschmidt, Aaron C. Hirko, Jeffrey A. Hughes, Michael A. King, Zhimin Li, Huong L. Moldthan, Ahmed S. Elshikha, Joanna Peris, Maria B. Grant, Yuanqing Lu, Sihong Song
Publikováno v:
Journal of Stroke and Cerebrovascular Diseases. 23:e355-e363
Currently, the only effective therapy for acute ischemic stroke is the thrombolytic agent recombinant tissue plasminogen activator. α1-Antitrypsin, an endogenous inhibitor of serine proteinases and a primary acute phase protein with potent anti-infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400c916a2f60b1c4419d7c4eb3d63afb
https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.12.029
https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.12.029
Publikováno v:
Stem Cells. 26:2893-2901
Rat umbilical cord matrix (RUCM) cells are stem-cell-like cells and have been shown to reduce neuronal loss in the selectively vulnerable brain regions after cardiac arrest (CA). Here, we investigate whether this protection is mediated by the RUCM ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b537a86ae8bcd039a84d9950dbe658fa
https://doi.org/10.1634/stemcells.2008-0075
https://doi.org/10.1634/stemcells.2008-0075
Publikováno v:
Molecular Therapy. 15(9):1623-1629
The accumulation and deposition of the 40-42-amino acid peptide amyloid beta (Abeta) is thought to be a critical event in the pathology of Alzheimer's disease (AD). Both passive and active immunizations against Abeta in amyloid-depositing transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cd92a3216a41de0dbc0b16fdbfc009
Autor:
Ralph Dawson, Masahiro Oka, Aaron C. Hirko, Naohiro Terada, Anthony Smith, Joanna Peris, Edwin M. Meyer, Yuka Nakano
Publikováno v:
Neurochemistry International. 45:1067-1073
This study characterized the presynaptic dopaminergic properties of neuronally differentiated mouse embryonic stem (ES) cells. Approximately 30% of the ES cells expressed tyrosine hydroxylase (TH) immunoreactivity when co-cultured with PA6 cells. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b57d260cf568e99dfb92f636edfae80
https://doi.org/10.1016/j.neuint.2004.05.005
https://doi.org/10.1016/j.neuint.2004.05.005
Publikováno v:
Current Medicinal Chemistry. 10:1185-1193
Successful gene therapy depends on efficient gene transfer vectors. Viral vectors and non-viral vectors have been investigated extensively. Cationic lipids are non-viral vectors, which resemble traditional pharmaceuticals, display little immunogenici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9066e8bec6bdd35ca1d82e3320a37639
https://doi.org/10.2174/0929867033457412
https://doi.org/10.2174/0929867033457412
Publikováno v:
Bioscience Reports. 22:297-308
Neurodegenerative diseases as a class do not have effective pharmacotherapies. This is due in part to a poor understanding of the pathologies of the disease processes, and the lack of effective medications. Gene delivery is an attractive possibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0c4da9c324071c5484ba5454088ec4
https://doi.org/10.1023/a:1020194807665
https://doi.org/10.1023/a:1020194807665
Autor:
Craig Meyers, Jeremy R. Grimes, Nicholas Muzyczka, Aaron C. Hirko, Ronald Klein, Edwin M. Meyer
Publikováno v:
Brain Research. 875:144-151
Administration of nerve growth factor (NGF) by intracerebroventricular infusion or transplantation of NGF-secreting cells to the basal forebrain improves spatial memory in aged animals. Using the adeno-associated virus (AAV) vector system, basal fore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1f671b0ea4a73118303fd513b00d7a
https://doi.org/10.1016/s0006-8993(00)02634-2
https://doi.org/10.1016/s0006-8993(00)02634-2
Autor:
Jeffrey S. Thinschmidt, Sihong Song, Joanna Peris, Huong T. Le, Maria B. Grant, Zhimin Li, Aaron C. Hirko, Michael A. King, Jeffrey A. Hughes
Publikováno v:
Experimental & Translational Stroke Medicine
Background To date, recombinant tissue plasminogen activator (rtPA) is the only approved drug for ischemic stroke. It is intravenously administered functioning as a thrombolytic agent and is used to obtain reperfusion of the affected area of the brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4511dd3a833da0038ec138307baf28
https://doi.org/10.1186/2040-7378-3-13
https://doi.org/10.1186/2040-7378-3-13
Publikováno v:
Molecular pharmaceutics. 7(4)
Polyethylenimine (PEI) was conjugated to phospholipase A(2) (PLA(2)) in an effort to improve transfection efficiency. PLA(2) was conjugated to PEI using EDC as a coupling reagent. The activity of enzyme in the conjugate was measured. DNA condensation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37bb4d0b3caef7233794757d8beac54
https://pubmed.ncbi.nlm.nih.gov/20459116
https://pubmed.ncbi.nlm.nih.gov/20459116