Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Aaron C Hinken"'
Autor:
Akshay Bareja, Jason A Holt, Guizhen Luo, Calvin Chang, Junyu Lin, Aaron C Hinken, Johannes M Freudenberg, William E Kraus, William J Evans, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90398 (2014)
Satellite cells are the chief contributor to skeletal muscle growth and regeneration. The study of mouse satellite cells has accelerated in recent years due to technical advancements in the isolation of these cells. The study of human satellite cells
Externí odkaz:
https://doaj.org/article/b59f032fb88a4b6cac5f3fde409dca6f
Autor:
Darren T Hwee, Adam Kennedy, Julie Ryans, Alan J Russell, Zhiheng Jia, Aaron C Hinken, David J Morgans, Fady I Malik, Jeffrey R Jasper
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96921 (2014)
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years
Externí odkaz:
https://doaj.org/article/2d8b4b2563864ca697b28f372dd39e3f
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 5, Pp 1321-1335 (2020)
Abstract Background Surgery can lead to significant muscle loss, which increases recovery time and associates with increased mortality. Muscle loss is not uniform, with some patients losing significant muscle mass and others losing relatively little,
Externí odkaz:
https://doaj.org/article/d39f2a9134fc4fa293f0f14109c4f970
Autor:
Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14930-14941
The discovery of reldesemtiv, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit 1 led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68
https://doi.org/10.1021/acs.jmedchem.1c01067
https://doi.org/10.1021/acs.jmedchem.1c01067
Autor:
Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau
Publikováno v:
Nature Communications. 13
During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs to regenerate is regulated by the primary cilium, a cellular protrusion t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f22939928b01fef055499da5b7d7786
https://doi.org/10.1038/s41467-022-29150-6
https://doi.org/10.1038/s41467-022-29150-6
Autor:
Alan J. Russell, David Neil, Mark J.D. Griffiths, Paul R. Kemp, Aaron C. Hinken, Richard Paul
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 5, Pp 1321-1335 (2020)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle
Background Surgery can lead to significant muscle loss, which increases recovery time and associates with increased mortality. Muscle loss is not uniform, with some patients losing significant muscle mass and others losing relatively little, and is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953388208b9e03ba18c9e1794d72c4ec
http://hdl.handle.net/10044/1/80732
http://hdl.handle.net/10044/1/80732
Autor:
Keren I. Hilgendorf, Helen M. Blau, Adelaida R. Palla, Aaron C. Hinken, Nora Yucel, Jaclyn P. Kerr, Peter K. Jackson, Ann V Yang, Nancie Mooney, Janos Demeter, Peggy E. Kraft
During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We performed a small molecule library screen and discovered that the proliferation and expansion of aged MuS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64abffcaf26c6e74fee59a18f6b51090
Autor:
Adelaida R, Palla, Keren I, Hilgendorf, Ann V, Yang, Jaclyn P, Kerr, Aaron C, Hinken, Janos, Demeter, Peggy, Kraft, Nancie A, Mooney, Nora, Yucel, David M, Burns, Yu Xin, Wang, Peter K, Jackson, Helen M, Blau
Publikováno v:
Nature communications. 13(1)
During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs to regenerate is regulated by the primary cilium, a cellular protrusion t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd442d505bfc3e9b064ea830d47e2422
https://pubmed.ncbi.nlm.nih.gov/35301320
https://pubmed.ncbi.nlm.nih.gov/35301320
Autor:
A Kennedy, Aaron C. Hinken, William F. Browne, Kwan Leung, Matthew Tomlinson, Bradley P Morgan, James J. Hartman, Pu-Ping Lu, Gustave Bergnes, Fady I. Malik, David J. Morgans, Alexander Muci, David Marquez, Marc Garard, Ion Suehiro, Scott Collibee, Kenneth Lee, Donghong Xu, Alan J. Russell, Julia Schaletzky, Raja Kawas, Darren Hwee
Publikováno v:
ACS Medicinal Chemistry Letters
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction with the troponin compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1cd746965443b1eee2a4f71ea7923b
http://europepmc.org/articles/PMC5900333
http://europepmc.org/articles/PMC5900333
Autor:
James J. Hartman, Darren T. Hwee, Jeffrey R. Jasper, Kenneth Lee, Alan J. Russell, Nickie Durham, Fady I. Malik, Arthur J. Cheng, Håkan Westerblad, Aaron C. Hinken
Publikováno v:
The Journal of Physiology. 595:1657-1670
Key points We report that the small molecule CK-2066260 selectively slows the off-rate of Ca2+ from fast skeletal muscle troponin, leading to increased myofibrillar Ca2+ sensitivity in fast skeletal muscle. Rodents dosed with CK-2066260 show increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e8899c62724edf68a11d3cf88e49a36
https://doi.org/10.1113/jp273248
https://doi.org/10.1113/jp273248