Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Aaron C Hinken"'
Autor:
Adelaida R. Palla, Keren I. Hilgendorf, Ann V. Yang, Jaclyn P. Kerr, Aaron C. Hinken, Janos Demeter, Peggy Kraft, Nancie A. Mooney, Nora Yucel, David M. Burns, Yu Xin Wang, Peter K. Jackson, Helen M. Blau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with agi
Externí odkaz:
https://doaj.org/article/1cb547b9df374953936e2d5fd08f29bc
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 5, Pp 1321-1335 (2020)
Abstract Background Surgery can lead to significant muscle loss, which increases recovery time and associates with increased mortality. Muscle loss is not uniform, with some patients losing significant muscle mass and others losing relatively little,
Externí odkaz:
https://doaj.org/article/d39f2a9134fc4fa293f0f14109c4f970
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments.
Externí odkaz:
https://doaj.org/article/e1f73e6f4eda4a62a3d79d3777de791e
Autor:
Dylan C. Sarver, Kristoffer B. Sugg, Jeffrey R. Talarek, Jacob B. Swanson, David J. Oliver, Aaron C. Hinken, Henning F. Kramer, Christopher L. Mendias
Publikováno v:
Physiological Reports, Vol 7, Iss 22, Pp n/a-n/a (2019)
Abstract Injured tendons heal through the formation of a fibrovascular scar that has inferior mechanical properties compared to native tendon tissue. Reducing inflammation that occurs as a result of the injury could limit scar formation and improve f
Externí odkaz:
https://doaj.org/article/37fe28bf7e6d448badd6ba6992c99b73
Autor:
Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:14930-14941
The discovery of reldesemtiv, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit 1 led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68
https://doi.org/10.1021/acs.jmedchem.1c01067
https://doi.org/10.1021/acs.jmedchem.1c01067
Autor:
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-1 (2018)
Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.
Externí odkaz:
https://doaj.org/article/d03026fdb79744668aebcc8fa062fee1
Autor:
Akshay Bareja, Jason A Holt, Guizhen Luo, Calvin Chang, Junyu Lin, Aaron C Hinken, Johannes M Freudenberg, William E Kraus, William J Evans, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90398 (2014)
Satellite cells are the chief contributor to skeletal muscle growth and regeneration. The study of mouse satellite cells has accelerated in recent years due to technical advancements in the isolation of these cells. The study of human satellite cells
Externí odkaz:
https://doaj.org/article/b59f032fb88a4b6cac5f3fde409dca6f
Autor:
Darren T Hwee, Adam Kennedy, Julie Ryans, Alan J Russell, Zhiheng Jia, Aaron C Hinken, David J Morgans, Fady I Malik, Jeffrey R Jasper
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96921 (2014)
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years
Externí odkaz:
https://doaj.org/article/2d8b4b2563864ca697b28f372dd39e3f
Autor:
Alan J. Russell, David Neil, Mark J.D. Griffiths, Paul R. Kemp, Aaron C. Hinken, Richard Paul
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 5, Pp 1321-1335 (2020)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle
Background Surgery can lead to significant muscle loss, which increases recovery time and associates with increased mortality. Muscle loss is not uniform, with some patients losing significant muscle mass and others losing relatively little, and is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953388208b9e03ba18c9e1794d72c4ec
http://hdl.handle.net/10044/1/80732
http://hdl.handle.net/10044/1/80732
Autor:
Keren I. Hilgendorf, Helen M. Blau, Adelaida R. Palla, Aaron C. Hinken, Nora Yucel, Jaclyn P. Kerr, Peter K. Jackson, Ann V Yang, Nancie Mooney, Janos Demeter, Peggy E. Kraft
During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We performed a small molecule library screen and discovered that the proliferation and expansion of aged MuS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64abffcaf26c6e74fee59a18f6b51090