Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Aaron Bender"'
Autor:
Huan Wang, Aaron Bender, Peng Wang, Esra Karakose, William B. Inabnet, Steven K. Libutti, Andrew Arnold, Luca Lambertini, Micheal Stang, Herbert Chen, Yumi Kasai, Milind Mahajan, Yayoi Kinoshita, Gustavo Fernandez-Ranvier, Thomas C. Becker, Karen K. Takane, Laura A. Walker, Shira Saul, Rong Chen, Donald K. Scott, Jorge Ferrer, Yevgeniy Antipin, Michael Donovan, Andrew V. Uzilov, Boris Reva, Eric E. Schadt, Bojan Losic, Carmen Argmann, Andrew F. Stewart
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highligh
Externí odkaz:
https://doaj.org/article/80c3e45c47014686a61554de1f26c1c1
Autor:
Pablo Ranea-Robles, Natalya N Pavlova, Aaron Bender, Andrea S Pereyra, Jessica M Ellis, Brandon Stauffer, Chunli Yu, Craig B Thompson, Carmen Argmann, Michelle Puchowicz, Sander M Houten
Publikováno v:
Cardiovasc Res
Aims Cardiomyopathy and arrhythmias can be severe presentations in patients with inherited defects of mitochondrial long-chain fatty acid β-oxidation (FAO). The pathophysiological mechanisms that underlie these cardiac abnormalities remain largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7961f1286b7ec77ba33a5ec0c170aaf1
https://doi.org/10.1093/cvr/cvac050
https://doi.org/10.1093/cvr/cvac050
Autor:
Sander M. Houten, Aaron Bender, Carmen Argmann, Pablo Ranea-Robles, Kensey Portman, John Cijiang He, David J. Mulholland, Kyung Lee
Publikováno v:
Kidney360
Background Proximal tubular (PT) cells are enriched in mitochondria and peroxisomes. Whereas mitochondrial fatty acid oxidation (FAO) plays an important role in kidney function by supporting the high-energy requirements of PT cells, the role of perox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1edb8c77886df2c0069821b909422ea
https://doi.org/10.34067/kid.0003772021
https://doi.org/10.34067/kid.0003772021
Autor:
Jerri Rook, Aaron Bender, Jonathan Dickerson, Daniel Foster, Alice Rodriguez, Colleen Niswender, Ellen Hess, Jeff Conn, Craig Lindsley
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::188d96ea359a5442df66cc04e707b53e
https://doi.org/10.1096/fasebj.2022.36.s1.l8009
https://doi.org/10.1096/fasebj.2022.36.s1.l8009
Autor:
Sander M. Houten, Carmen Argmann, Natalya N. Pavlova, Aaron Bender, Brandon Stauffer, Pablo Ranea-Robles, Chunli Yu, Craig B. Thompson, Michelle Puchowicz
The heart relies mainly on mitochondrial fatty acid β-oxidation (FAO) for its high energy requirements. Cardiomyopathy and arrhythmias can be severe complications in patients with inherited defects in mitochondrial long-chain FAO, reinforcing the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37fa253ccae014d55647ad80736b2dc5
https://doi.org/10.1101/2021.05.13.443905
https://doi.org/10.1101/2021.05.13.443905
Autor:
Pablo Ranea-Robles, KathyAnn Lee, Sander M. Houten, Carmen Argmann, John Cijiang He, Kensey Portman, Aaron Bender, David J. Mulholland
BackgroundProximal tubular (PT) cells are enriched in mitochondria and peroxisomes. Whereas mitochondrial fatty acid oxidation (FAO) plays an important role in kidney function by supporting the high-energy requirements of PT cells, the role of peroxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beefbf3311ca7277d0e0f56b81bcfe2c
https://doi.org/10.1101/2021.03.14.435187
https://doi.org/10.1101/2021.03.14.435187
Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains
Publikováno v:
Molecular genetics and metabolism. 132(2)
The glutaric acidurias are a group of inborn errors of metabolism with different etiologies. Glutaric aciduria type 3 (GA3) is a biochemical phenotype with uncertain clinical relevance caused by a deficiency of succinyl-CoA:glutarate-CoA transferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db431c1457b0eb5bfb83db6a28bbc492
https://pubmed.ncbi.nlm.nih.gov/33483254
https://pubmed.ncbi.nlm.nih.gov/33483254
Autor:
Nahum Sonenberg, Akiko Yanagiya, Aaron Bender, Margarita Jimenez-Palomares, Manuel Blandino-Rosano, Ming Liu, Rebecca Barbaresso, Ernesto Bernal-Mizrachi, Joshua O. Scheys, Liangyou Rui
Publikováno v:
Diabetes
The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d115ab0f22721461edd3b4f0bb7ceabc
https://doi.org/10.2337/db15-1443
https://doi.org/10.2337/db15-1443
Autor:
Evan G. Williams, Carmen Argmann, Sander M. Houten, Wei Zhang, Chunli Yu, Johan Auwerx, Alexis Maximilien Bachmann, João Leandro, Sara Violante, Aaron Bender, Jacob Hagen, Tetyana Dodatko
Publikováno v:
Molecular genetics and metabolism. 126(4)
Inbred mouse strains are a cornerstone of translational research but paradoxically many strains carry mild inborn errors of metabolism. For example, α-aminoadipic acidemia and branched-chain ketoacid dehydrogenase deficiency are known in C57BL/6J mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb116f0783f7aed77e1640cf115a0825
https://pubmed.ncbi.nlm.nih.gov/30709776
https://pubmed.ncbi.nlm.nih.gov/30709776
Autor:
Juan-Carlos Alvarez-Perez, Aaron Bender, Sharmila Sivendran, Andrew F. Stewart, Adolfo Garcia-Ocaña, Peng Wang, Donald K. Scott, Roberto Sanchez, Dan P. Felsenfeld, Anil Kumar, Hongtao Liu
Publikováno v:
Nature Medicine. 21:383-388
Types 1 and 2 diabetes affect some 380 million people worldwide. Both ultimately result from a deficiency of functional pancreatic insulin-producing beta cells. Beta cells proliferate in humans during a brief temporal window beginning around the time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc285a296772196107afb4469c2e6f35
https://doi.org/10.1038/nm.3820
https://doi.org/10.1038/nm.3820