Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aaron B. Reeve"'
Autor:
Maria E. Cilento, Xin Wen, Aaron B. Reeve, Obiaara B. Ukah, Alexa A. Snyder, Ciro M. Carrillo, Cole P. Smith, Kristin Edwards, Claudia C. Wahoski, Deborah R. Kitzler, Eiichi N. Kodama, Hiroaki Mitsuya, Michael A. Parniak, Philip R. Tedbury, Stefan G. Sarafianos
Publikováno v:
Viruses, Vol 15, Iss 10, p 1990 (2023)
Tenofovir disoproxil fumarate (TDF) and islatravir (ISL, 4′-ethynyl-2-fluoro-2′-deoxyadensine, or MK-8591) are highly potent nucleoside reverse transcriptase inhibitors. Resistance to TDF and ISL is conferred by K65R and M184V, respectively. Furt
Externí odkaz:
https://doaj.org/article/f8179306a49c4f7ea7367c95413a0d0c
Autor:
Michael A. Parniak, Philip R. Tedbury, Stefan G. Sarafianos, Aaron B. Reeve, Eva Nagy, Tatiana V Ilina, Maria E. Cilento, Eleftherios Michailidis, Hiroaki Mitsuya
Publikováno v:
Antimicrob Agents Chemother
4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA, MK-8591, islatravir) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with exceptional potency against wild-type (WT) and drug-resistant HIV-1 in phase III clinical trials. EFdA re
Autor:
Mary E. Moreno, Michael Murphey-Corb, Stefan G. Sarafianos, Jose M. Rivera, Barbara Sloan, Cheryl A. Stoddart, Galina Kosikova, Pheroze Joshi, Michael A. Parniak, Sofiya A. Galkina, Aaron B. Reeve
Publikováno v:
Antimicrobial agents and chemotherapy, vol 59, iss 7
Like normal cellular nucleosides, the nucleoside reverse transcriptase (RT) inhibitor (NRTI) 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) has a 3′-hydroxyl moiety, and yet EFdA is a highly potent inhibitor of human immunodeficiency virus (HIV)
Autor:
Aaron B. Reeve, Francis J. Novembre, Shawn P. O'Neil, Katherine V. Augustus, Kalpana Patel, Heber G. Domingues, Nicholas C. Pearce
Publikováno v:
AIDS Research and Human Retroviruses. 25:583-601
The simian lentivirus strain SIVsmmFGb is a viral swarm population inducing neuropathology in over 90% of infected pigtailed macaques and serves as a reliable model for HIV neuropathogenesis. However, little is understood about the genetic diversity
Autor:
Maxwell D. Leslie, Michael A. Parniak, Eleftherios Michailidis, Yee Tsuey Ong, Karen A. Kirby, Lisa C. Rohan, Hiroaki Mitsuya, Eiichi Kodama, Aaron B. Reeve, Stefan G. Sarafianos, Bruno Marchand, Shinichi Oka, Atsuko Hachiya
Publikováno v:
Antimicrobial agents and chemotherapy. 57(9)
Drug combination studies of 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) with FDA-approved drugs were evaluated by two different methods, MacSynergy II and CalcuSyn. Most of the combinations, including the combination of the two adenosine analogs
Autor:
Premeela A. Rajakumar, Hiroaki Mitsuya, Michael A. Parniak, Julia Nyaundi, Michael Murphey-Corb, Heather Michael, Aaron B. Reeve, Stefan G. Sarafianos, Peter J. Didier
Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) are essential components in first-line therapy for human immunodeficiency virus (HIV) infection. However, long-term treatment with existing NRTIs can be associated with significant toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafb03a93693dffee0928ee70c8a2257
https://europepmc.org/articles/PMC3421895/
https://europepmc.org/articles/PMC3421895/
Autor:
Francis J. Novembre, Katherine V. Augustus, Nicholas C. Pearce, Aaron B. Reeve, Kalpana Patel
Publikováno v:
AIDS research and human retroviruses. 26(6)
SIVsmmFGb is a lentivirus swarm that induces neuropathology in over 90% of infected pigtailed macaques and reliably models central nervous system HIV infection in people. We have previously studied SIVsmmFGb genetic diversity and compartmentalization