Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aaron B. Benjamin"'
Autor:
Madeleine G. Moule, Aaron B. Benjamin, Melanie L. Burger, Claudine Herlan, Maxim Lebedev, Jennifer S. Lin, Kent J. Koster, Neha Wavare, Leslie G. Adams, Stefan Bräse, Ricardo Munoz-Medina, Carolyn L. Cannon, Annelise E. Barron, Jeffrey D. Cirillo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract The rise of drug resistance has become a global crisis, with >1 million deaths due to resistant bacterial infections each year. Pseudomonas aeruginosa, in particular, remains a serious problem with limited solutions due to complex resistance
Externí odkaz:
https://doaj.org/article/ab40fd863f304eb4a471e70484e74673
Autor:
Madeleine G. Moule, Aaron B. Benjamin, Melanie L. Burger, Claudine Herlan, Maxim Lebedev, Jennifer S. Lin, Kent J. Koster, Neha Wavare, Leslie G. Adams, Stefan Bräse, Ricardo Munoz-Medina, Carolyn L. Cannon, Annelise E. Barron, Jeffrey D. Cirillo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/b6356ca139474b47a0ccb2ae4fd36b91
Autor:
Andrew R. DiNardo, Moshe Arditi, Ashish M. Kamat, Kent J. Koster, Santiago Carrero, Tomoki Nishiguchi, Maxim Lebedev, Aaron B. Benjamin, Pablo Avalos, Marisa Lozano, Madeleine G. Moule, Brittany McCune, Baysia Herron, Malik Ladki, Daanish Sheikh, Matthew Spears, Ivan A. Herrejon, Courtney Dodge, Sathish Kumar, Robert W. Hutchison, Theresa U. Ofili, Lynne A. Opperman, Jessica A. Bernard, Seth P. Lerner, George Udeani, Gabriel Neal, Mihai G. Netea, Jeffrey D. Cirillo
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Background A large epidemic, such as that observed with SARS-CoV-2, seriously challenges available hospital capacity, and this would be augmented by infection of healthcare workers (HCW). Bacillus Calmette-Guérin (BCG) is a vaccine against
Externí odkaz:
https://doaj.org/article/dcb9a63f260c439d9bbf3e7bf439dfe9
Autor:
Maxim Lebedev, Aaron B. Benjamin, Sathish Kumar, Natalia Molchanova, Jennifer S. Lin, Kent J. Koster, Julian L. Leibowitz, Annelise E. Barron, Jeffrey D. Cirillo
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 464 (2024)
New antiviral agents are essential to improving treatment and control of SARS-CoV-2 infections that can lead to the disease COVID-19. Antimicrobial peptoids are sequence-specific oligo-N-substituted glycine peptidomimetics that emulate the structure
Externí odkaz:
https://doaj.org/article/7b24857c92f74ec191ebd9ad305568d0
Autor:
Aaron B. Benjamin, Madeleine G. Moule, Maruti K. Didwania, Jonathan Hardy, Panatda Saenkham-Huntsinger, Preeti Sule, Josefine Eilsø Nielsen, Jennifer S. Lin, Christopher H. Contag, Annelise E. Barron, Jeffrey D. Cirillo
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Staphylococcus aureus is one of the most common pathogens associated with infection in wounds. The current standard of care uses a combination of disinfection and drainage followed by conventional antibiotics such as methicillin. Methicillin
Externí odkaz:
https://doaj.org/article/8e921a2943fb4dafa117f86e91624304
Autor:
Maxim Lebedev, Aaron B. Benjamin, Kent J. Koster, Kathryn E. Broyles, Sathish Kumar, Joseph M. Jilka, Jeffrey D. Cirillo
Publikováno v:
Diagnostics, Vol 12, Iss 7, p 1745 (2022)
Tuberculosis is one of the most frequent causes of death in humans worldwide. One of the primary reasons tuberculosis remains a public health threat is that diagnosis can take weeks to months, is often not very sensitive and cannot be accomplished in
Externí odkaz:
https://doaj.org/article/eb98b19203bf4f4faa318b2042817fcf
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 79:61-69
Acetyl coenzyme A (acetyl-CoA) is a reactive metabolite that nonproductively hydrolyzes in a number of enzyme active sites in the crystallization time frame. In order to elucidate the enzyme–acetyl-CoA interactions leading to catalysis, acetyl-CoA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c518f1dd29604af094581647b8649c4c
https://doi.org/10.1107/s2053230x23001206
https://doi.org/10.1107/s2053230x23001206
Autor:
Trevor J. Boram, Aaron B. Benjamin, Amanda Silva de Sousa, Lee M. Stunkard, Taylor A. Stewart, Timothy J. Adams, Nicholas A. Craft, Kevin G. Velázquez-Marrero, Jianheng Ling, Jaelen N. Nice, Jeremy R. Lohman
Publikováno v:
ACS Chemical Biology. 18:49-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd3e722017460ce6032d0dd59b4d205
https://doi.org/10.1021/acschembio.2c00667
https://doi.org/10.1021/acschembio.2c00667
Crystal structures of Streptomyces coelicolor methylmalonyl-CoA epimerase in the holo-form, with substrate or the putative transition state analog, 2-nitroproionyl-CoA. The proposed catalytic mechanism is general acid-base catalysis. The proposed cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df9998b78867ba87b27f7ea1d36faae
https://doi.org/10.26434/chemrxiv.14403929
https://doi.org/10.26434/chemrxiv.14403929
Dissertation/ Thesis
Autor:
Aaron B Benjamin (9175175)
Thioesters are highly reactive centers for acyl-CoAs which allows them to be utilized in a variety of differing enzyme chemistries. As a result of this reactivity, structure-function studies of enzymes using acyl-CoA substrates is difficult. When acy