Výsledky vyhledávání - "Aaron Atkinson"

Abstract 6074: Germline and somatic genomic profiling of urothelial carcinoma

Publikováno v: Cancer Research. 83:6074-6074

Urothelial carcinoma (UC) presents most frequently as bladder cancer and is the most common cancer of the urinary system in the United States. UC relapse and progression are common and impose a significant negative impact on the lives of patients and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc9bc520c4b09f3c3ff6d82936e0b7bf
https://doi.org/10.1158/1538-7445.am2023-6074

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Abstract 3506: High-grade serous ovarian cancer somatic mutational signatures in Black and White individuals

Autor: Katherine A. Lawson-Michod, David Nix, Lindsay Collin, Natalie Davidson, Ariel Hippen, Chad Huff, Aaron Atkinson, Lucas A. Salas, Lauren Peres, Casey Greene, Joellen Schildkraut, Jeffrey Marks, Jennifer A. Doherty

Publikováno v: Cancer Research. 83:3506-3506

Causes of racial disparities in ovarian cancer survival are likely multifactorial, including socio-environmental, structural, and biological factors. Mutational signatures reflect endogenous and exogenous exposures, which may differ by race and ethni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6610b9722576cde604351d6d19253269
https://doi.org/10.1158/1538-7445.am2023-3506

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Abstract 5901: Germline tissue sequencing in patients with solid tumors uncovers clonal hematopoiesis variants

Publikováno v: Cancer Research. 82:5901-5901

The peripheral blood (PB) is broadly used as a source of germline tissue for next generation sequencing in both clinical and research settings. Incidental or secondary findings are often uncovered at the time of germline sequencing. Current guideline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6beb74d3bda975760b13c6a95d63f4cd
https://doi.org/10.1158/1538-7445.am2022-5901

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Inherited germline variants in urothelial cancer: A multicenter whole-exome sequencing analysis

Publikováno v: Journal of Clinical Oncology. 40:451-451

451 Background: Outside of Lynch syndrome, few genetic factors have been associated with urothelial cancer (UC). This project seeks to describe the frequency of germline variants in a multi-center UC cohort. Methods: Patients diagnosed with UC from 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cb8764a5a958d80041d7b6f9c123623
https://doi.org/10.1200/jco.2022.40.6_suppl.451

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The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria

Autor: Aaron Atkinson, Dennis R. Winge, Jennifer L. Fox, Pamela M. Smith, Oleh Khalimonchuk, Tie-Zhong Cui

Publikováno v: Molecular and cellular biology. 31(19)

The assembly of the cytochrome bc(1) complex in Saccharomyces cerevisiae is shown to be conditionally dependent on a novel factor, Mzm1. Cells lacking Mzm1 exhibit a modest bc(1) defect at 30°C, but the defect is exacerbated at elevated temperatures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fe3e8c3231999770555e514e20b281
https://pubmed.ncbi.nlm.nih.gov/21807901

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Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function

Autor: David J. Eide, Pamela M. Smith, Oleh Khalimonchuk, Dennis R. Winge, Aaron Atkinson, Hana Sabic

Publikováno v: The Journal of biological chemistry. 285(25)

Zinc is essential for function of mitochondria as a cofactor for several matrix zinc metalloproteins. We demonstrate that a labile cationic zinc component of low molecular mass exists in the yeast mitochondrial matrix. This zinc pool is homeostatical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584bf039a21101ad3f4e88265980e4cd
https://pubmed.ncbi.nlm.nih.gov/20404342

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