Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Aaron A Hoskins"'
Publikováno v:
eLife, Vol 11 (2022)
In eukaryotes, splice sites define the introns of pre-mRNAs and must be recognized and excised with nucleotide precision by the spliceosome to make the correct mRNA product. In one of the earliest steps of spliceosome assembly, the U1 small nuclear r
Externí odkaz:
https://doaj.org/article/e72c81db7599402eb17d42af4cccfd84
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0229315 (2020)
Mutations in the splicing machinery have been implicated in a number of human diseases. Most notably, the U2 small nuclear ribonucleoprotein (snRNP) component SF3b1 has been found to be frequently mutated in blood cancers such as myelodysplastic synd
Externí odkaz:
https://doaj.org/article/57492dad03e94b7a93bb5aa1a9d79a45
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Splice site recognition is essential for defining the transcriptome. Drugs like risdiplam and branaplam change how human U1 snRNP recognizes particular 5′ splice sites (5′SS) and promote U1 snRNP binding and splicing at these locations.
Externí odkaz:
https://doaj.org/article/ab7585aca3a24b5ebc80331ebd19ecf0
Autor:
Joshua Donald Larson, Aaron A Hoskins
Publikováno v:
eLife, Vol 6 (2017)
The spliceosome must identify the correct splice sites (SS) and branchsite (BS) used during splicing. E complex is the earliest spliceosome precursor in which the 5' SS and BS are defined. Definition occurs by U1 small nuclear ribonucleoprotein (snRN
Externí odkaz:
https://doaj.org/article/a0c7787d62a84686940d378f8be94b3a
Publikováno v:
eLife, Vol 5 (2016)
The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs. After assembly the spliceosome is activated for catalysis by rearrangement of subunits to form an a
Externí odkaz:
https://doaj.org/article/38d552474b4040a498a9eb18049e312d
Autor:
Judith Kimble, William M Bement, Qiang Chang, Benjamin L Cox, Norman R Drinkwater, Richard L Gourse, Aaron A Hoskins, Anna Huttenlocher, Pamela K Kreeger, Paul F Lambert, Marsha R Mailick, Shigeki Miyamoto, Richard L Moss, Kate M O'Connor-Giles, Avtar Roopra, Krishanu Saha, Hannah S Seidel
Publikováno v:
eLife, Vol 4 (2015)
A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.
Externí odkaz:
https://doaj.org/article/977f332b05b245bbb249d515b2ab0389
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 525-538 (2023)
Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome. Given the spliceosome's role in shaping the cellular transcriptome, it is not surprising tha
Externí odkaz:
https://doaj.org/article/ffa85d3a02b74e05a7d837128a80011d
Autor:
Kassandra Hernandez, Aaron B. Hoskins
Publikováno v:
Trees, Forests and People, Vol 15, Iss , Pp 100516- (2024)
This study focuses on using Machine Learning methods to predict wildfires within California's Central Valley. The specific areas within the Central Valley were Yosemite Valley, Sequoias, and Kings Canyon since these areas can be considered wildfire h
Externí odkaz:
https://doaj.org/article/ef28abedc43248dea9d96d1f01b9317d
Publikováno v:
Advances in Space Research. 70:1013-1031
Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
Autor:
Allison L. Didychuk, Eric J. Montemayor, Tucker J. Carrocci, Andrew T. DeLaitsch, Stefani E. Lucarelli, William M. Westler, David A. Brow, Aaron A. Hoskins, Samuel E. Butcher
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional a
Externí odkaz:
https://doaj.org/article/af0bae0e35e0403b9769387c02748283