Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Aaron A Diaz"'
Autor:
Cathy Pichol-Thievend, Oceane Anezo, Aafrin M. Pettiwala, Guillaume Bourmeau, Remi Montagne, Anne-Marie Lyne, Pierre-Olivier Guichet, Pauline Deshors, Alberto Ballestín, Benjamin Blanchard, Juliette Reveilles, Vidhya M. Ravi, Kevin Joseph, Dieter H. Heiland, Boris Julien, Sophie Leboucher, Laetitia Besse, Patricia Legoix, Florent Dingli, Stephane Liva, Damarys Loew, Elisa Giani, Valentino Ribecco, Charita Furumaya, Laura Marcos-Kovandzic, Konstantin Masliantsev, Thomas Daubon, Lin Wang, Aaron A. Diaz, Oliver Schnell, Jürgen Beck, Nicolas Servant, Lucie Karayan-Tapon, Florence M. G. Cavalli, Giorgio Seano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Glioblastoma (GBM) is a highly lethal type of cancer. GBM recurrence following chemoradiation is typically attributed to the regrowth of invasive and resistant cells. Therefore, there is a pressing need to gain a deeper understanding of the
Externí odkaz:
https://doaj.org/article/3b619e0cc25442dda280674d2cd28cb1
Autor:
Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz, Hideho Okada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider a
Externí odkaz:
https://doaj.org/article/4c9ca26f096d46feb278b4dfc8e66f04
Autor:
Husam Babikir, Lin Wang, Karin Shamardani, Francisca Catalan, Sweta Sudhir, Manish K. Aghi, David R. Raleigh, Joanna J. Phillips, Aaron A. Diaz
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prog
Externí odkaz:
https://doaj.org/article/1f912e20cb9c45bfa17d01103b13cc81
Autor:
Lin Wang, Karin Shamardani, Husam Babikir, Francisca Catalan, Takahide Nejo, Susan Chang, Joanna J. Phillips, Hideho Okada, Aaron A. Diaz
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Alternative splicing is a rich source of tumor-specific neoantigen targets for immunotherapy. This holds promise for glioblastomas (GBMs), the most common primary tumors of the adult brain, which are resistant to standard-of-care
Externí odkaz:
https://doaj.org/article/f4e1f927f7564becaa0351b1e74db697
Autor:
Itay Raphael, Rajeev Kumar, Lauren H. McCarl, Karsen Shoger, Lin Wang, Poorva Sandlesh, Chaim T. Sneiderman, Jordan Allen, Shuyan Zhai, Marissa Lynn Campagna, Alexandra Foster, Tullia C. Bruno, Sameer Agnihotri, Baoli Hu, Brandyn A. Castro, Frank S. Lieberman, Alberto Broniscer, Aaron A. Diaz, Nduka M. Amankulor, Dhivyaa Rajasundaram, Ian F. Pollack, Gary Kohanbash
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Glioblastoma (GBM) remains an aggressive brain tumor with a high rate of mortality. Immune checkpoint (IC) molecules are expressed on tumor infiltrating lymphocytes (TILs) and promote T cell exhaustion upon binding to IC ligands expressed by the tumo
Externí odkaz:
https://doaj.org/article/aec74bbb1c6b4bd1b658f3f136f5b61d
Autor:
Aaron A. Diaz, Manish K. Aghi, Joanna J. Phillips, Susan M. Chang, Harsh Wadhwa, Sumedh Shah, Arnold Kriegstein, Elizabeth Di Lullo, Beatriz Alvarado, Gary Kohanbash, Francisca Catalan, Karin Shamardani, Garima Yagnik, Sören Müller, Husam Babikir, Lin Wang
Although tumor-propagating cells can be derived from glioblastomas (GBM) of the proneural and mesenchymal subtypes, a glioma stem-like cell (GSC) of the classic subtype has not been identified. It is unclear whether mesenchymal GSCs (mGSC) and/or pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c5a1ed46ea1b2a678e1ee4ecdf7fff
https://doi.org/10.1158/2159-8290.c.6548086
https://doi.org/10.1158/2159-8290.c.6548086
Autor:
Aaron A. Diaz, Manish K. Aghi, Joanna J. Phillips, Susan M. Chang, Harsh Wadhwa, Sumedh Shah, Arnold Kriegstein, Elizabeth Di Lullo, Beatriz Alvarado, Gary Kohanbash, Francisca Catalan, Karin Shamardani, Garima Yagnik, Sören Müller, Husam Babikir, Lin Wang
Table S1: Clinical and molecular characteristics of the glioma cases profiled by scRNA-seq.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad78905dff81bdf3b45694fd88f7b4ce
https://doi.org/10.1158/2159-8290.22536250.v1
https://doi.org/10.1158/2159-8290.22536250.v1
Autor:
Aaron A. Diaz, Manish K. Aghi, Joanna J. Phillips, Susan M. Chang, Harsh Wadhwa, Sumedh Shah, Arnold Kriegstein, Elizabeth Di Lullo, Beatriz Alvarado, Gary Kohanbash, Francisca Catalan, Karin Shamardani, Garima Yagnik, Sören Müller, Husam Babikir, Lin Wang
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd69a3eb723fb5d8ec3b43529a90683
https://doi.org/10.1158/2159-8290.22536253.v1
https://doi.org/10.1158/2159-8290.22536253.v1
Autor:
Manish K. Aghi, Sanjay Kumar, Luke A. Gilbert, Aaron A. Diaz, Jonathan W. Rick, Sören Müller, Jung-Ming G. Lin, Kayla J. Wolf, Jacob Weiss, Rushikesh S. Joshi, Harsh Wadhwa, Sumedh S. Shah, Joseph H. Garcia, Saket Jain, Matheus P. Pereira, Garima Yagnik, Alan T. Nguyen, William Chen, Arman Jahangiri, Ankush Chandra
Supplementary Table S2 has primer sequences used to analyze expression of genes known to be expressed by GBM stem cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b990e318aee6b351b6fa77ac0194ec
https://doi.org/10.1158/0008-5472.22424869.v1
https://doi.org/10.1158/0008-5472.22424869.v1
Autor:
Manish K. Aghi, Sanjay Kumar, Luke A. Gilbert, Aaron A. Diaz, Jonathan W. Rick, Sören Müller, Jung-Ming G. Lin, Kayla J. Wolf, Jacob Weiss, Rushikesh S. Joshi, Harsh Wadhwa, Sumedh S. Shah, Joseph H. Garcia, Saket Jain, Matheus P. Pereira, Garima Yagnik, Alan T. Nguyen, William Chen, Arman Jahangiri, Ankush Chandra
Glioblastoma (GBM) responses to bevacizumab are invariably transient with acquired resistance. We profiled paired patient specimens and bevacizumab-resistant xenograft models pre- and post-resistance toward the primary goal of identifying regulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa10d7708df640a9d9374f33293f856
https://doi.org/10.1158/0008-5472.c.6511885
https://doi.org/10.1158/0008-5472.c.6511885