Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Aaron, Rigby"'
Autor:
Elizabeth Kinchin, Lilian Alcaraz, Aaron Rigby, Haydn Beaton, Matt Soars, Rebecca Denton, Keith Bowers, Ash Bahl, David Donald, John Collington, Cathy MacDonald, Rob Riley, Peter J. H. Webborn, Christopher A. Luckhurst, Brian Springthorpe, Mark Furber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7702-7706
The discovery of potent small molecule dual antagonists of the human CCR3 and H(1) receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326676355fb09074d590653a96585ff3
https://doi.org/10.1016/j.bmcl.2012.09.113
https://doi.org/10.1016/j.bmcl.2012.09.113
Autor:
Aaron Rigby, Peter J. H. Webborn, Rob Riley, John Collington, Mark Furber, Brian Springthorpe, Matt Soars, Ash Bahl, Cathy MacDonald, Keith Bowers, Elizabeth Kinchin, Lilian Alcaraz, Rebecca Denton, Haydn Beaton, David Donald, Christopher A. Luckhurst
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7707-7710
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H(1) dual antagonists described in Part I. This involved further structural exploration directed at reducing metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a2660289e12b8effe0ecbfde4d5f050
https://doi.org/10.1016/j.bmcl.2012.09.112
https://doi.org/10.1016/j.bmcl.2012.09.112
Autor:
Mark, Furber, Lilian, Alcaraz, Christopher, Luckhurst, Ash, Bahl, Haydn, Beaton, Keith, Bowers, John, Collington, Rebecca, Denton, David, Donald, Elizabeth, Kinchin, Cathy, MacDonald, Aaron, Rigby, Rob, Riley, Matt, Soars, Brian, Springthorpe, Peter, Webborn
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H(1) dual antagonists described in Part I. This involved further structural exploration directed at reducing metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b265960f1cf196e20fed3d284455964f
https://pubmed.ncbi.nlm.nih.gov/23116889
https://pubmed.ncbi.nlm.nih.gov/23116889
Autor:
Mark, Furber, Lilian, Alcaraz, Christopher, Luckhurst, Ash, Bahl, Haydn, Beaton, Keith, Bowers, John, Collington, Rebecca, Denton, David, Donald, Elizabeth, Kinchin, Cathy, MacDonald, Aaron, Rigby, Rob, Riley, Matt, Soars, Brian, Springthorpe, Peter, Webborn
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
The discovery of potent small molecule dual antagonists of the human CCR3 and H(1) receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f02a7236d2b3e6e812e2998f262f09f1
https://pubmed.ncbi.nlm.nih.gov/23142617
https://pubmed.ncbi.nlm.nih.gov/23142617
Autor:
Adam Sisson, Steve Brough, Evans Richard, Patrick Barton, Keith Bowers, Christopher A. Luckhurst, Perry Matthew, Aaron Rigby, Robert J. Riley, Hitesh J. Sanganee, Ash Bahl, Tobias Mochel, Brian Springthorpe
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(21)
A series of dual CCR3/H1 antagonists based on a bispiperidine scaffold were discovered. Introduction of an acidic group overcame hERG liability. Bioavailability was optimised by modulation of physico-chemical properties and physical form to deliver a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d487e180cf067fd117022b4e08004f05
https://pubmed.ncbi.nlm.nih.gov/23031591
https://pubmed.ncbi.nlm.nih.gov/23031591
Autor:
Anthony Ingall, Brian Springthorpe, Simon Guile, Chapman David, Paul D. Leeson, Timothy Nicholas Birkinshaw, Garry Pairaudeau, Simon F. Hunt, John Dixon, Michael Mortimore, Richard J. Lewis, Barry Teobald, Dermot F. McGinnity, Brown Roger Charles, Stuart W. Paine, Anil Patel, Robert J. Riley, Francis Ince, Wendy Tomlinson, Kirk Ian, Roger Bonnert, Andrew Bailey, Aaron Rigby, Patrick Barton, Paul Willis, Barrie Martin, P. Leff, R.G. Humphries, Peter J. H. Webborn
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described. Modifications of the acidic side chain and the purine core and investigation of hydrophobic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6951535cd7d2c326d389158dd07fcea
https://pubmed.ncbi.nlm.nih.gov/17827008
https://pubmed.ncbi.nlm.nih.gov/17827008