Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Aaron, Randolph"'
Autor:
Markus Rapedius, Alison Obergrussberger, Edward S. A. Humphries, Stephanie Scholz, Ilka Rinke-Weiss, Tom A. Goetze, Nina Brinkwirth, Maria Giustina Rotordam, Tim Strassmaier, Aaron Randolph, Søren Friis, Aiste Liutkute, Fitzwilliam Seibertz, Niels Voigt, Niels Fertig
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Fluoride has been used in the internal recording solution for manual and automated patch clamp experiments for decades because it helps to improve the seal resistance and promotes longer lasting recordings. In manual patch clamp, fluoride has been us
Externí odkaz:
https://doaj.org/article/83adde9de25943fbbe36f6b380522509
Autor:
Paul B. Fisher, Devanand Sarkar, Kristoffer Valerie, Aaron Randolph, Luni Emdad, Irina V. Lebedeva, Zao-zhong Su, Mark R. Walter, Pankaj Gupta
Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that induces cancer-selective growth suppression and apoptosis in a wide spectrum of human cancers in cell culture and animal models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce29768368f8cc64c31211e3b016817
https://doi.org/10.1158/0008-5472.c.6494534.v1
https://doi.org/10.1158/0008-5472.c.6494534.v1
Autor:
Paul B. Fisher, Devanand Sarkar, Kristoffer Valerie, Aaron Randolph, Luni Emdad, Irina V. Lebedeva, Zao-zhong Su, Mark R. Walter, Pankaj Gupta
Supplementary Table 1 from BiP/GRP78 Is an Intracellular Target for MDA-7/IL-24 Induction of Cancer-Specific Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1524e70c4e938e38b13b294e62619218
https://doi.org/10.1158/0008-5472.22365107.v1
https://doi.org/10.1158/0008-5472.22365107.v1
Autor:
Nadine Becker, Mohammadreza Samieegohar, John Imredy, Jin Zhai, Anders Lindqvist, Søren Friis, Nina Brinkwirth, Tim Strassmaier, Jae Kwagh, James Kramer, Jingsong Fan, Paul Levesque, Sonja Stoelzle-Feix, Bradley J. Ridder, Herbert Himmel, Timm Danker, Derek J. Leishman, Markus Rapedius, Liudmila Polonchuk, Jiansong Sheng, Marc Rogers, Gary R. Mirams, Simon Hebeisen, Haiyang Wei, George Okeyo, Evgenia Gissinger, Tom A. Goetze, Phu N. Tran, Zhihua Li, Rémi Bardenet, Yuri A. Kuryshev, Muthukrishnan Renganathan, Maria Giustina Rotordam, Aaron Randolph, Daniel Konrad, Robert W. Kirby, Wendy W. Wu, Caiyun Wu, David G. Strauss, Matthew Bridgland-Taylor, Bryan Koci, Edward Humphries, Xiaomei Han
Publikováno v:
Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Introduction hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and a lack of statistical quantificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944e258ca318d261e63e5e97ce793630
http://europepmc.org/articles/PMC7166077
http://europepmc.org/articles/PMC7166077
Autor:
Habib, Boukerche, Zao-Zhong, Su, Luni, Emdad, Patrick, Baril, Brigitte, Balme, Luc, Thomas, Aaron, Randolph, Kristoffer, Valerie, Devanand, Sarkar, Paul B, Fisher
Publikováno v:
Cancer research. 79(19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da9c83a9d93a3269a7310e0b0cd7e20b
https://pubmed.ncbi.nlm.nih.gov/16322237
https://pubmed.ncbi.nlm.nih.gov/16322237
Autor:
Jiansong Sheng, Claudia Alvarez Baron, Min Wu, David G. Strauss, Nicolas Thiebaud, Phu N. Tran, Wendy W. Wu, Donna A. Volpe, Ksenia Blinova, Dakshesh Patel, Ming Ren, Lars Johannesen, Aaron Randolph
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241362 (2020)
PLoS ONE, Vol 15, Iss 11, p e0241362 (2020)
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTCprolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e4ae1975a14ae3e9a13995b652208c
https://doi.org/10.1371/journal.pone.0241362
https://doi.org/10.1371/journal.pone.0241362
Autor:
Søren Friis, Jiansong Sheng, Tim Strassmaier, David G. Strauss, Tom A. Goetze, Wendy W. Wu, Zhihua Li, Phu N. Tran, Sonja Stoelzle-Feix, Maria Giustina Rotordam, Yuri A. Kuryshev, James Kramer, Xiaomei Han, Nina Brinkwirth, George Okeyo, Caiyun Wu, Bradley J. Ridder, Markus Rapedius, Nadine Becker, Mohammadreza Samieegohar, Aaron Randolph
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106890
Introduction In response to the ongoing shift of the regulatory cardiac safety paradigm, a recent White Paper proposed general principles for developing and implementing proarrhythmia risk prediction models. These principles included development stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7848a8e34c37f208cd232abf2882a2
https://doi.org/10.1016/j.vascn.2020.106890
https://doi.org/10.1016/j.vascn.2020.106890
Autor:
Daniel Konrad, James Kramer, John Imredy, Anders Lindqvist, Haiyang Wei, Evgenia Gissinger, Tim Strassmaier, Jae Kwagh, Søren Friis, Aaron Randolph, Caiyun Wu, Muthukrishnan Renganathan, David G. Strauss, Jingsong Fan, Edward Humphries, George Okeyo, Timm Danker, Nina Brinkwirth, Bradley J. Ridder, Robert W. Kirby, Wendy W. Wu, Markus Rapedius, Phu N. Tran, Nadine Becker, Mohammadreza Samieegohar, Jiansong Sheng, Marc Rogers, Paul Levesque, Sonja Stoelzle-Feix, Herbert Himmel, Bryan Koci, Yuri A. Kuryshev, Matthew Bridgland-Taylor, Liudmila Polonchuk, Jin Zhai, Tom A. Goetze, Zhihua Li, Xiaomei Han, Simon Hebeisen, Rémi Bardenet, Gary R. Mirams, Maria Giustina Rotordam, Derek J. Leishman
Publikováno v:
Toxicology and Applied Pharmacology. 395:114983
© 2020 The Author(s) The authors regret that one affiliation address is mistaken in the published paper. Matthew Bridgland-Taylor's affiliation was incorrectly listed as Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9325ed3f56c1916f5af5315ccfb4082
https://doi.org/10.1016/j.taap.2020.114983
https://doi.org/10.1016/j.taap.2020.114983
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 100:106605
Introduction Cardiac late Na+ current (INaL) contributes to ventricular action potential duration. Pathological increase in INaL is arrhythmogenic, and inhibition of INaL offers protection against ventricular repolarization disturbance. Recently, two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bac9e584f5947f565078244cdaa580a
https://doi.org/10.1016/j.vascn.2019.106605
https://doi.org/10.1016/j.vascn.2019.106605