Výsledky vyhledávání - "Aaron, Janowsky"

Akademický článek

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.

Autor: Jennifer M Loftis, Michael Lasarev, Xiao Shi, Jodi Lapidus, Aaron Janowsky, William F Hoffman, Marilyn Huckans

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0220270 (2019)

BackgroundMethamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involveme

Externí odkaz: https://doaj.org/article/cc5448f2e84b47b78eb752cafb282caf

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Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)(2A) Receptor (5-HT(2A)R), 5-HT(2C)R, 5-HT(1A)R, and Serotonin Transporter

Autor: Laura B. Kozell, Amy J. Eshleman, Tracy L. Swanson, Shelley H. Bloom, Katherine M. Wolfrum, Jennifer L. Schmachtenberg, Randall J. Olson, Aaron Janowsky, Atheir I. Abbas

Publikováno v: J Pharmacol Exp Ther

Novel psychoactive substances, including synthetic substituted tryptamines, represent a potential public health threat. Additionally, some substituted tryptamines are being studied under medical guidance as potential treatments of psychiatric disorde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c873bdb6d466b99885f6445a49a7ca
https://europepmc.org/articles/PMC10029822/

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Development of a translational model to assess the impact of opioid overdose and naloxone dosing on respiratory depression and cardiac arrest

Autor: John Mann, Mohammadreza Samieegohar, Anik Chaturbedi, Joel Zirkle, Xiaomei Han, S. Farzad Ahmadi, Amy Eshleman, Aaron Janowsky, Katherine Wolfrum, Tracy Swanson, Shelley Bloom, Albert Dahan, Erik Olofsen, Jeffry Florian, David G. Strauss, Zhihua Li

Publikováno v: Clinical Pharmacology & Therapeutics, 112(5), 1020-1032. WILEY

In response to a surge of deaths from synthetic opioid overdoses, there have been increased efforts to distribute naloxone products in community settings. Prior research has assessed the effectiveness of naloxone in the hospital setting; however, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f88f489c8c0988eede7606bebd9ffb5
https://hdl.handle.net/1887/3572107

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Akademický článek

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.

Autor: Xiao Shi, Nicole A R Walter, John H Harkness, Kim A Neve, Robert W Williams, Lu Lu, John K Belknap, Amy J Eshleman, Tamara J Phillips, Aaron Janowsky

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0152581 (2016)

Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and β-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1). TAAR1 has been implicated in human conditions includin

Externí odkaz: https://doaj.org/article/7030c05efd874274b2cf2d34ae5accc5

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Fentanyl but not Morphine Interacts with Nonopioid Recombinant Human Neurotransmitter Receptors and Transporters

Autor: Jennifer L. Schmachtenberg, John F. Reed, Randy Torralva, Tracy L. Swanson, William E. Schutzer, Katherine M. Wolfrum, Amy J. Eshleman, Shelley H. Bloom, Aaron Janowsky

Publikováno v: J Pharmacol Exp Ther

Synthetic opioids, including fentanyl and its analogs, have therapeutic efficacy in analgesia and anesthesia. However, their illicit use in the United States has increased and contributed to the number one cause of death for adults 18–50 years old.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e92ee3ca2ff2d4f14709bce93e7be2
https://doi.org/10.1124/jpet.120.265561

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