Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Aaron, Goldman"'
Autor:
Chen Wang, Hideki Tanizawa, Connor Hill, Aaron Havas, Qiang Zhang, Liping Liao, Xue Hao, Xue Lei, Lu Wang, Hao Nie, Yuan Qi, Bin Tian, Alessandro Gardini, Andrew V. Kossenkov, Aaron Goldman, Shelley L. Berger, Ken-ichi Noma, Peter D. Adams, Rugang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent manner by driving changes in high
Externí odkaz:
https://doaj.org/article/510df8c88f934aa994ca58141deaa581
Autor:
Mohamed Abdel-Mohsen, Steven Deeks, Leila Giron, Kai Ying Hong, Aaron Goldman, Liao Zhang, Susie S. Y. Huang, Donovan Verrill, Susan Guo, Lisa Selzer, Christiaan R. de Vries, Elena Vendrame, Devi SenGupta, Jeffrey J. Wallin, Yanhui Cai
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundAntiretroviral therapy (ART) for HIV-1 treatment has improved lifespan but requires lifelong adherence for people living with HIV (PLWH), highlighting the need for a cure. Evaluation of potential cure strategies requires analytic treatment
Externí odkaz:
https://doaj.org/article/095bab4f17fa480d8c63f5de87ce6252
Autor:
Nafiseh Moghimi, Seied Ali Hosseini, Altay Burak Dalan, Dorsa Mohammadrezaei, Aaron Goldman, Mohammad Kohandel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Cancer treatment resistance is a caused by presence of various types of cells and heterogeneity within the tumor. Tumor cell–cell and cell-microenvironment interactions play a significant role in the tumor progression and invasion, which h
Externí odkaz:
https://doaj.org/article/c0dcc5cb872d45aaa1d60c507f1c363f
Autor:
Aaron Goldman, Ketki Bhise, Chunxiao (Emma) Cui, Kirti Khardenavis, Anthony Attardo, Danielle Hagee, Sinal Patel, Julia Vail, Amir Aref, Nicholas Barris, Alyssa Martin, Michael A Perricone
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/64752b4b365a4801ac72c0fd0320ac0f
Autor:
Michelle Przedborski, Munisha Smalley, Saravanan Thiyagarajan, Aaron Goldman, Mohammad Kohandel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Michelle Przedborski et al. report an integrative systems biology and machine learning method for predicting cancer patient responses to immunotherapy treatment. Using their method, they identify several new drug combinations that could potentially i
Externí odkaz:
https://doaj.org/article/44e3f66755784e83bdb6e51e9bad3437
Autor:
Adrianne L. Jenner, Munisha Smalley, David Goldman, William F. Goins, Charles S. Cobbs, Ralph B. Puchalski, E. Antonio Chiocca, Sean Lawler, Paul Macklin, Aaron Goldman, Morgan Craig
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104395- (2022)
Summary: Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in the treatment of some tumors, OV therapy for central nervous system cancers has failed to show efficacy. We used an ex vivo tumor model developed from hu
Externí odkaz:
https://doaj.org/article/ce0d47aff0b143b1858eb624b2a4a00d
Autor:
Tanmoy Saha, Amanda A. van Vliet, Chunxiao Cui, Jorge Jimenez Macias, Arpita Kulkarni, Luu Nhat Pham, Sean Lawler, Jan Spanholtz, Anna-Maria Georgoudaki, Adil Doganay Duru, Aaron Goldman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Allogeneic natural killer (aNK) cell adoptive therapy has the potential to dramatically impact clinical outcomes of glioblastoma multiforme (GBM). However, in order to exert therapeutic activity, NK cells require tumor expression of ligands for activ
Externí odkaz:
https://doaj.org/article/e47ed6b00c7f48eaa54b2fa0f80f11a6
Autor:
Munisha Smalley, Michelle Przedborski, Saravanan Thiyagarajan, Moriah Pellowe, Amit Verma, Nilesh Brijwani, Debika Datta, Misti Jain, Basavaraja U. Shanthappa, Vidushi Kapoor, Kodaganur S. Gopinath, D.C. Doval, K.S. Sabitha, Gaspar Taroncher-Oldenburg, Biswanath Majumder, Pradip Majumder, Mohammad Kohandel, Aaron Goldman
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101229- (2020)
Summary: Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to int
Externí odkaz:
https://doaj.org/article/575a67d6a91847c882f2028f31c0496f
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Tunnelling nanotubes (TNTs), also known as membrane nanochannels, are actin-based structures that facilitate cytoplasmic connections for rapid intercellular transfer of signals, organelles and membrane components. These dynamic TNTs can form
Externí odkaz:
https://doaj.org/article/3783a9eaa90a41248302445182794b9f
Autor:
Morgan Craig, Kamran Kaveh, Alec Woosley, Andrew S Brown, David Goldman, Elliot Eton, Ravindra M Mehta, Andrew Dhawan, Kazuya Arai, M Mamunur Rahman, Sidi Chen, Martin A Nowak, Aaron Goldman
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1007278 (2019)
Understanding intrinsic and acquired resistance is crucial to overcoming cancer chemotherapy failure. While it is well-established that intratumor, subclonal genetic and phenotypic heterogeneity significantly contribute to resistance, it is not fully
Externí odkaz:
https://doaj.org/article/0d6fffb3382f4d45ba2967ac1a7ed714