Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes

Autor: Caner Saygin, Ashwin Kishtagari, Ryan D. Cassaday, Natalie Reizine, Ilana Yurkiewicz, Michaela Liedtke, Wendy Stock, Richard A. Larson, Ross L. Levine, Martin S. Tallman, Jae H. Park, Cassandra Kerr, Bartlomiej Przychodzen, Mikkael A. Sekeres, Matt E. Kalaycio, Hetty E. Carraway, Betty K. Hamilton, Ronald Sobecks, Aaron Gerds, Sudipto Mukherjee, Aziz Nazha, Jaroslaw P. Maciejewski, Anjali S. Advani

Publikováno v: Blood Advances, Vol 3, Iss 24, Pp 4228-4237 (2019)

Abstract: Patients with therapy-related acute lymphoblastic leukemia (t-ALL) represent a small subset of acute lymphoblastic leukemia (ALL) patients who received genotoxic therapy (ie, chemotherapy or radiation) for a prior malignancy. These patients

Externí odkaz: https://doaj.org/article/cab86d84cd7c4e9c8f87db118e5bdbb6

Supplementary Tables from Integrated Human and Murine Clinical Study Establishes Clinical Efficacy of Ruxolitinib in Chronic Myelomonocytic Leukemia

Autor: Eric Padron, Rami S. Komrokji, Mikkael A. Sekeres, Alan F. List, Jeffrey E. Lancet, Hailing Zhang, Traci Kruer, Markus Ball, Maria E. Balasis, Christopher Letson, William Dominguez-Viqueira, David A. Sallman, Aaron Gerds, Onyee Chan, Qianxing Mo, Gail J. Roboz, Sandrine Niyongere, David P. Steensma, Amy E. Dezern, Hannah Newman, Anthony M. Hunter

Supplementary Table S1 details the IWG response criteria for MDS/MPNs. Supplementary Table S2 summarizes grade 3 and 4 treatment-emergent toxicities. Supplementary Table S3 summarizes all recorded adverse events. Supplementary Table S4 summarizes the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546a01d27e36ac313485050cabac7a27
https://doi.org/10.1158/1078-0432.22480698.v1

Data from Integrated Human and Murine Clinical Study Establishes Clinical Efficacy of Ruxolitinib in Chronic Myelomonocytic Leukemia

Autor: Eric Padron, Rami S. Komrokji, Mikkael A. Sekeres, Alan F. List, Jeffrey E. Lancet, Hailing Zhang, Traci Kruer, Markus Ball, Maria E. Balasis, Christopher Letson, William Dominguez-Viqueira, David A. Sallman, Aaron Gerds, Onyee Chan, Qianxing Mo, Gail J. Roboz, Sandrine Niyongere, David P. Steensma, Amy E. Dezern, Hannah Newman, Anthony M. Hunter

Purpose:Chronic myelomonocytic leukemia (CMML) is a rare leukemia characterized by peripheral monocytosis with no disease-modifying therapies. CMML cells are uniquely hypersensitive to granulocyte-macrophage colony-stimulating factor (GM-CSF) and rob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3051e3248a86b6314849860553cc89b3
https://doi.org/10.1158/1078-0432.c.6530514

Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM):results from an international, double-blind, randomised, controlled, phase 3 study

Autor: Srdan Verstovsek, Aaron T Gerds, Alessandro M Vannucchi, Haifa Kathrin Al-Ali, David Lavie, Andrew T Kuykendall, Sebastian Grosicki, Alessandra Iurlo, Yeow Tee Goh, Mihaela C Lazaroiu, Miklos Egyed, Maria Laura Fox, Donal McLornan, Andrew Perkins, Sung-Soo Yoon, Vikas Gupta, Jean-Jacques Kiladjian, Nikki Granacher, Sung-Eun Lee, Luminita Ocroteala, Francesco Passamonti, Claire N Harrison, Barbara J Klencke, Sunhee Ro, Rafe Donahue, Jun Kawashima, Ruben Mesa, Adi Shacham Abulafia, Bjorn Andreasson, Anna Angona, Rosa Ayala, Soo-Mee Bang, Bruce Bank, Fiorenza Barraco, Eloise Beggiato, Fleur Samantha Benghiat, MassimiliaNo Bonifacio, Claire Bories, Gabriela Borsaru, Mette Brabrand, Andrei Braester, Andes Broliden, Veronika Buxhofer-Ausch, Nathalie Cambier, Marianna Caramella, Benjamin Carpentier, Nicola Cascavilla, Maria Giraldo Castellano, Hung Chang, Chih-Cheng Chen, June-Won Cheong, Yunsuk Choi, Philip Choi, Maria Teresa Corsetti, Isabel Montero Cuadrado, Julia Cunningham, Gandhi Laurent Damaj, Valerio De Stefano, Robert Delage, Regina Garcĺa Delgado, Jose Miguel Torregrosa Diaz, Péter Dombi, Viviane Dubruille, Miklós Egyed, Daniel El Fassi, Anna Elinder-Camburn, Elena Maria Elli, Martin Ellis, Carmen Fava, Salman Fazal, Angela Fleischman, Lynda Foltz, Laura Fox, Nashat Gabrail, Jose Valentĺn Garcĺa-Gutiérrez, Aaron Gerds, Stephane Girault, Heinz Gisslinger, Alexandru Gluvacov, Joachim Göthert, Evgeni (Evgueniy) Hadjiev (Hadzhiev), Kaoutar Hafraoui, Aryan Hamed, Claire Harrison, Hans Hasselbalch, Hanns Hauser, Mark Heaney, Holger Hebart, Jesus Maria Hernandez Rivas, Victor Higuero Saavedra, Christopher Hillis, Hsin-An Hou, Jonathan How, Daniel Huang, Marek Hus, Arpad Illés, Alessandro Isidori, Vadim Ivanov, Peter Johansson, Chul Won Jung, Ilya Kirgner, Maya Koren-Michowitz, Steffen Koschmieder, Szabolcs Ors Kosztolanyi, Natalia Kreiniz, Andrew Kuykendall, Jonathan Lambert, Kamel Laribi, Axelle Lascaux, Noa Lavie, Mihaela Lazaroiu, Michael Leahy, Ewa Lech-Maranda, Won Sik Lee, Ollivier Legrand, Roberto Lemoli, James Liang, Sung-Nam Lim, Michael Loschi, Alessandro Lucchesi, Ioan Macarie, Jean-Pierre Marolleau, Maurizio Martelli, Jiri Mayer, James McCloskey, Christopher McDermott, Brandon McMahon, Priyanka Mehta, Gábor Mikala, Dragana Milojkovic, Philippe Mineur, Elena Mishchenko, Joon Ho Moon, Zsolt Nagy, Srinivasan Narayanan, Casey O'Connell, Stephen Oh, Mario Ojeda-Uribe, Kiat Hoe Ong, Folashade Otegbeye, Jeanne Palmer, Fabrizio Pane, Andrea Patriarca, Giuseppe Pietrantuono, Mark Plander, Uwe Platzbecker, Ritam Prasad, Witold Prejzner, Tobias Rachow, Atanas Radinoff, László Rejtő, Ciro Rinaldi, Tadeusz Robak, Maria Angeles Fernandez Rodriguez, Aaron Ronson, David Ross, Tomasz Sacha, Parvis Sadjadian, Antonio Salar, Guillermo Sanz Santillana, Christof Scheid, Aline Schmidt, Marianne Tang Severinsen, Vera Stoeva, Paweł Szwedyk, Mario Tiribelli, Karolin Trautmann-Grill, Amy Trottier, Nikolay Tzvetkov, Janusz van Droogenbroeck, Alessandro Vannucchi, Nicola Vianelli, Nikolas von Bubnoff, Dominik Wolf, Dariusz Woszczyk, Tomasz Woźny, Tomasz Wróbel, Blanca Xicoy, Su-Peng Yeh

Publikováno v: Verstovsek, S, Gerds, A, Vannucchi, A, Vannucchi, A, Al-Ali, H K, Lavie, D, Kuykendall, A T, Grosicki, S, Iurlo, A, Goh, Y T, Lazaroiu, M C, Egyed, M, Fox, M L, McLornan, D, Harrison, C N, Perkins, A, Yoon, S S, Gupta, V, Kiladjian, J J, Granacher, N, Lee, S E, Ocroteala, L, Passamonti, F, Klencke, B J, Ro, S, Donahue, R, Kawashima, J, Mesa, R, MOMENTUM Study Investigators & Severinsen, M T 2023, ' Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM) : results from an international, double-blind, randomised, controlled, phase 3 study ', The Lancet, vol. 401, no. 10373, pp. 269-280 . https://doi.org/10.1016/S0140-6736(22)02036-0

BACKGROUND: Janus kinase (JAK) inhibitors approved for myelofibrosis provide spleen and symptom improvements but do not meaningfully improve anaemia. Momelotinib, a first-in-class inhibitor of activin A receptor type 1 as well as JAK1 and JAK2, has s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0a29b32da77b75b50f0a41ca3581cd
https://vbn.aau.dk/da/publications/00e2be43-3d7e-42ce-a974-744fc61bd9e2

MPN-469 Rusfertide (PTG-300) Treatment Interruption Reverses Hematological Gains and Upon Reinitiation, Restoration of Clinical Benefit Observed in Patients With Polycythemia Vera

Autor: Naveen Pemmaraju, Andrew Kuykendall, Marina Kremyanskaya, Yelena Ginzburg, Ellen Ritchie, Jason Gotlib, Aaron Gerds, Jeanne Palmer, Frank Valone, Paula O'Connor, Nishit Modi, Suneel Gupta, Ronald Hoffman, Srdan Verstovsek

Publikováno v: Clinical lymphoma, myelomaleukemia. 22

Polycythemia vera (PV) patients are routinely treated with periodic therapeutic phlebotomy (TP) alone or combined with cytoreductive therapy to maintain hematocrit (HCT)45% and reduce the incidence of thrombosis. TP may not adequately control HCT and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe4885a4ada900c4a59f7c6280e317
https://pubmed.ncbi.nlm.nih.gov/36164011