Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Aaron, Ehlinger"'
Autor:
Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stim
Externí odkaz:
https://doaj.org/article/6c3b35c0421a4ab2b8722df6acbdcac6
Autor:
Fahu He, Hans-Peter Wollscheid, Urszula Nowicka, Matteo Biancospino, Eleonora Valentini, Aaron Ehlinger, Filippo Acconcia, Elisa Magistrati, Simona Polo, Kylie J. Walters
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2683-2694 (2016)
Myosin VI is critical for cargo trafficking and sorting during early endocytosis and autophagosome maturation, and abnormalities in these processes are linked to cancers, neurodegeneration, deafness, and hypertropic cardiomyopathy. We identify a stru
Externí odkaz:
https://doaj.org/article/711b4be1280c41119c21b4ef156c7f0c
Autor:
Urszula Nowicka, Hans-Peter Wollscheid, Eleonora Valentini, Elisa Magistrati, Kylie J. Walters, Filippo Acconcia, Fahu He, Aaron Ehlinger, Matteo Biancospino, Simona Polo
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2683-2694 (2016)
Summary Myosin VI is critical for cargo trafficking and sorting during early endocytosis and autophagosome maturation, and abnormalities in these processes are linked to cancers, neurodegeneration, deafness, and hypertropic cardiomyopathy. We identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd6417a39c637fd54b8548b94121ef
Autor:
Pi-Chiang Hsu, Sora Lee, W. Hayes McDonald, Walter J. Chazin, Kristin K. Jernigan, Susan J. Qualls-Histed, Aaron Ehlinger, Jason A. MacGurn, Jessica M Tumolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8419d3c4136a9244a73fae0619c3854c
https://doi.org/10.7554/elife.29176.035
https://doi.org/10.7554/elife.29176.035
Autor:
Jessica M Tumolo, Jason A. MacGurn, Susan J. Qualls-Histed, Sora Lee, Kristin K. Jernigan, Pi Chiang Hsu, W. Hayes McDonald, Aaron Ehlinger, Walter J. Chazin
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Despite its central role in protein degradation little is known about the molecular mechanisms that sense, maintain, and regulate steady state concentration of ubiquitin in the cell. Here, we describe a novel mechanism for regulation of ubiquitin hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32676beaca6bbded0fd4c8bc1aa9fad
http://europepmc.org/articles/PMC5706963
http://europepmc.org/articles/PMC5706963
Autor:
Aaron Ehlinger, Marilyn E. Holt, Jacqueline K. Barton, Matthew K. Thompson, Lauren E. Salay, Elizabeth O’Brien, Walter J. Chazin
Baranovskiy et al . and Pellegrini argue that, based on structural data, the path for charge transfer through the [4Fe4S] domain of primase is not feasible. Our manuscript presents electrochemical data directly showing charge transport through DNA to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dacd18b5b12efefe52f20e80f645462
https://resolver.caltech.edu/CaltechAUTHORS:20170720-130038340
https://resolver.caltech.edu/CaltechAUTHORS:20170720-130038340
Autor:
Matthew K. Thompson, Walter J. Chazin, Aaron Ehlinger, Elizabeth O’Brien, Jacqueline K. Barton, Lauren E. Salay, Marilyn E. Holt
Publikováno v:
Science. 355
DNA charged with regulating replication DNA can transport electrical charge over long distances and has the potential to act as a signaling system. The iron-sulfur complex [4Fe4S] found in some proteins is known to be involved in redox reactions. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d81f191ac477589cff696b396d1909
https://doi.org/10.1126/science.aag1789
https://doi.org/10.1126/science.aag1789
Multiprotein machines drive virtually all primary cellular processes. Modular multidomain proteins are widely distributed within these dynamic complexes because they provide the flexibility needed to remodel structure as well as rapidly assemble and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f6751115a46aa1e487a2b291363958
https://doi.org/10.1016/bs.mie.2017.03.017
https://doi.org/10.1016/bs.mie.2017.03.017
Autor:
Aaron Ehlinger, Jeffrey W. Lary, James L. Cole, Soyeon Park, Amr Fahmy, Daniel Finley, Kylie J. Walters
Publikováno v:
Structure. 21(5):753-765
SummaryJuxtaposed to either or both ends of the proteasome core particle (CP) can exist a 19S regulatory particle (RP) that recognizes and prepares ubiquitinated proteins for proteolysis. RP triphosphatase proteins (Rpt1–Rpt6), which are critical f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc1400533b3fdb3cd06f5ddd9e472e5
Autor:
Thomas A, Guilliam, Nigel C, Brissett, Aaron, Ehlinger, Benjamin A, Keen, Peter, Kolesar, Elaine M, Taylor, Laura J, Bailey, Howard D, Lindsay, Walter J, Chazin, Aidan J, Doherty
Publikováno v:
Nature Communications
DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most euka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::063ecee0150004eabcb25edd4d553162
https://pubmed.ncbi.nlm.nih.gov/28534480
https://pubmed.ncbi.nlm.nih.gov/28534480