Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Aarif Y, Khakoo"'
Autor:
Jeffrey E. Gotts, Mazharul Maishan, Lauren Chun, Xiaohui Fang, Chun‐Ya Han, Venice Chiueh, Aarif Y. Khakoo, TaeWeon Lee, Marina Stolina, Michael A. Matthay
Publikováno v:
Physiological Reports, Vol 9, Iss 21, Pp n/a-n/a (2021)
Abstract Influenza remains a major cause of death and disability with limited treatment options. Studies of acute lung injury have identified angiopoietin‐2 (Ang‐2) as a key prognostic marker and a potential mediator of Acute respiratory distress
Externí odkaz:
https://doaj.org/article/b29d331877234c9bb8ba6528693709e0
Autor:
Xin Luo, Kenneth B. Margulies, Aarif Y. Khakoo, Jun Yin, Kavita Sharma, David A. Kass, Virginia S. Hahn, Marina Stolina, Joel S. Bader, Kenneth Bedi, Joban Vaishnav, Saptarsi M. Haldar, Hildur Knutsdottir
Publikováno v:
Circulation. 143:120-134
Background: Heart failure (HF) with preserved ejection fraction (HFpEF) constitutes half of all HF but lacks effective therapy. Understanding of its myocardial biology remains limited because of a paucity of heart tissue molecular analysis. Methods:
Publikováno v:
FEBS Open Bio
Pericytes (PCs) in general are known to help maintain vessel integrity; however, their specific function in the heart is not well defined. Our in vitro study details NG2+ PDGFRβ+ CD146+ CD34− CD31− CD45− cardiac PC phenotypic and functional ch
Autor:
Kia N. Zellars, Eva Romito, Heather Doviak, Tae-Weon Lee, Gregory L. Brower, Parker D. Freels, Stephen W. Smith, David C Lobb, James A Shuman, Lisa A. Freeburg, Francis G. Spinale, Aarif Y. Khakoo, Jason W. O’Neill
Publikováno v:
J Pharmacol Exp Ther
Infarct expansion can occur after myocardial infarction (MI), which leads to adverse left ventricular (LV) remodeling and failure. An imbalance between matrix metalloproteinase (MMP) induction and tissue inhibitors of MMPs (TIMPs) can accelerate this
Publikováno v:
JACC: Basic to Translational Science
Summary Despite the fact that cardiovascular disease (CVD) is the number 1 cause of death globally, investment in drug development and new drug approvals for CVD are precipitously declining. In contrast, the trajectory of both investment in developme
Autor:
Shayne C. Barlow, TaeWeon Lee, Heather Doviak, Ran Klein, Julia Jacobs, Robert A. deKemp, Kia N. Zellars, Albert J. Sinusas, Jennifer M. Renaud, Stephanie Thorn, Mitchel R. Stacy, Attila Feher, Aarif Y. Khakoo, Francis G. Spinale
Publikováno v:
Circulation: Cardiovascular Imaging. 12
Background: The induction of matrix metalloproteinases (MMPs) and reduction in tissue inhibitors of MMPs (TIMPs) plays a role in ischemia/reperfusion (I/R) injury post-myocardial infarction (MI) and subsequent left ventricular remodeling. We develope
Autor:
Stephanie L, Thorn, Shayne C, Barlow, Attila, Feher, Mitchel R, Stacy, Heather, Doviak, Julia, Jacobs, Kia, Zellars, Jennifer M, Renaud, Ran, Klein, Robert A, deKemp, Aarif Y, Khakoo, TaeWeon, Lee, Francis G, Spinale, Albert J, Sinusas
Publikováno v:
Circ Cardiovasc Imaging
BACKGROUND: The induction of matrix metalloproteinases (MMPs), and reduction in tissue inhibitors of MMPs (TIMPs) plays a role in ischemia/reperfusion (I/R) injury post myocardial infarction (MI) and subsequent left ventricular (LV) remodeling. We de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::685352f51ea018d646f9eb2c5d3d8023
https://europepmc.org/articles/PMC7250243/
https://europepmc.org/articles/PMC7250243/
Autor:
Jonathan B. Houze, Andrea Boden, Ning Li, Dongming M. Liu, Xun Li, Jing Man Wong, Paul John Dransfield, Khanh Nguyen, Sridharan Rajamani, Gayathri Swaminath, Weston Sutherland, Yaping Sun, Ying Zhang, Vatee Pattaropong, Rhonda Chen, Vishnu Chintalgattu, Xiaochuan Ma, Murielle M. Véniant, Jim R. Turk, Ray W. Chui, Jinghong Wang, BaoXi Gao, Mark R. Fielden, Joyce Chi Yee Chan, Hugo M. Vargas, Kimberly M. Hoagland, Yinhong Chen, Yusheng Qu, Aarif Y. Khakoo, Shirley Mihardja, Qi Guo, Brandon Ason, Liaoyuan A. Hu, Ji Ma
Publikováno v:
JCI Insight
Heart failure (HF) remains a grievous illness with poor prognosis even with optimal care. The apelin receptor (APJ) counteracts the pressor effect of angiotensin II, attenuates ischemic injury, and has the potential to be a novel target to treat HF.
Publikováno v:
Journal of Visualized Experiments.
Pericytes, perivascular cells of microvessels and capillaries, are known to play a part in angiogenesis, vessel stabilization, and endothelial barrier integrity. However, their tissue-specific functions in the heart are not well understood. Moreover,
Autor:
Vishnu Chintalgattu, Jason W. O'Neill, Aarif Y. Khakoo, Amy Gilbert, Shivani Singh, TaeWeon Lee, Joanne Greenberg, Venice Chiueh, Simon Jackson, Stephen Smith
Publikováno v:
Pharmacology Research & Perspectives
Tissue Inhibitor of Metalloproteinase 3 (TIMP3) is a secreted protein that has a great utility to inhibit elevated metalloproteinase (MMP) activity in injured tissues including infarcted cardiac tissue, inflamed vessels, and joint cartilages. An imba