Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Autor: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-20 (2021)

Abstract Background The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldwide. Since cells alte

Externí odkaz: https://doaj.org/article/cd492dd27f6048c9a645568ac4114063

Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma

Autor: Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal‐Egaña, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Færgeman, Ole N Jensen, Rasmus Siersbæk, Kumar Somyajit, Paolo Ceppi

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-24 (2023)

Abstract The epithelial‐to‐mesenchymal transition (EMT) plays a central role in the development of cancer metastasis and resistance to chemotherapy. However, its pharmacological treatment remains challenging. Here, we used an EMT‐focused integr

Externí odkaz: https://doaj.org/article/f6a02b7c4b9e494a97d706c0ba7228b7

Supplementary Table from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells

Autor: Paolo Ceppi, Thomas Brabletz, Florian R. Greten, Marco Volante, Ozgur Sahin, Peter J. Oefner, Dimitrios Mougiakakos, Suhail Ahmed Kabeer Rasheed, Arif B. Ekici, Maximilian J. Waldner, Katja Dettmer-Wilde, Ida Rapa, Fulvia Ferrazzi, Angela M. Krebs, Özge Saatci, Umar Raza, Bianca Menchicchi, Martin Böttcher, Francesca Napoli, Maria Eleni Vazakidou, Aarif Siddiqui, Annemarie Schwab

List of differentially expressed genes in all analyzed datasets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e2addf3d6c8de2c1035abed96f614b
https://doi.org/10.1158/0008-5472.22420745

Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling

Autor: Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Simon Toftholm Jakobsen, Elisa Le Boiteux, Karen Ege Olsen, Ole Nørregaard Jensen, Rasmus Siersbæk, Kumar Somyajit, Paolo Ceppi

Epithelial to mesenchymal transition (EMT) is a developmental cellular program driving metastasis and chemo-resistance in cancer, but its pharmacological treatment has been so far challenging. Targeting deregulated metabolic processes in cancer is em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::229a5b93a3c21e71de0a819e454b6871
https://doi.org/10.1101/2023.01.19.524677

Down-Regulation of CK2α Leads to Up-Regulation of the Cyclin-Dependent Kinase Inhibitor p27KIP1 in Conditions Unfavorable for the Growth of Myoblast Cells

Autor: Mohammad Aarif Siddiqui, Barbara Guerra, Maja Dembic, Paolo Ceppi, Isabel Dominguez, Brage S. Andresen

Publikováno v: Cellular Physiology and Biochemistry, Vol 54, Iss 6, Pp 1177-1198 (2020)
Guerra, B, Dembic, M, Siddiqui, M A, Dominguez, I, Ceppi, P & Andresen, B S 2020, ' Down-regulation of CK2α leads to up-regulation of the cyclin-dependent kinase inhibitor p27KIP1 in conditions unfavorable for the growth of myoblast cells ', Cellular Physiology and Biochemistry, vol. 54, no. 6, pp. 1177-1198 . https://doi.org/10.33594/000000308

BACKGROUND/AIMS: Compelling evidence indicates that CK2α, which is one of the two catalytic isoforms of protein kinase CK2, is required for cell viability and plays an important role in cell proliferation and differentiation. While much is known on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faac6ea035c772464b1938725783e4d
https://www.cellphysiolbiochem.com/Articles/000308/