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Akademický článek

Inhibition of interleukin-12 expression by α-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses.

Autor: Naldini, A.¹ naldini@Unisi.it, Aarden, L.², Pucci, A.¹, Bernini, C.¹, Carraro, F.¹

Publikováno v: British Journal of Pharmacology. Nov2003, Vol. 140 Issue 5, p980-986. 7p. 6 Graphs.

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Akademický článek

Isotype-specific cross-linking of select human FcγR isoforms triggers release of IL-6.

Autor: Duits, A. J.¹, Aarden, L. A.², Ernst, L. K.³, Capel, P. J. A.¹, Van De Winkel, J. G. J.¹

Publikováno v: Clinical & Experimental Immunology. May1993, Vol. 92 Issue 2, p225-231. 7p.

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The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab

Autor: Mierlo, G.J.D. van, Cnubben, N.H.P., Wouters, D., Wolbink, G.J., Hart, M.H.L., Rispens, T., Ganderup, N.C., Kuper, C.F., Aarden, L., Penninks, A.H.

Publikováno v: Journal of Immunotoxicology, 1, 11, 62-71

Immunogenicity is a major issue of concern for monoclonal antibodies used in human diseases and is by default mainly determined in non-human primates (NHP), as target molecules are considered most similar in NHP compared to human. In this manuscript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8c5f4daad3eb3ab1629fc50cb9c46871
http://resolver.tudelft.nl/uuid:ca660385-2196-4ed1-a4f3-384dd6ba9502

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Akademický článek

From Poisson Distribution to Interleukins.

Autor: Aarden, L.¹ l.aarden@sanquin.nl

Publikováno v: Scandinavian Journal of Immunology. Jul2005 Supplement 1, Vol. 62, p33-35. 3p.

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Akademický článek

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Patients with systemic lupus erythematosus with high plasma levels of sFas risk relapse

Autor: van Lopik, T., Bijl, M., Hart, M., Boeije, L., Gesner, T., Creasy, A. A., Kallenberg, C. G., Aarden, L. A., Smeenk, R. J.

Publikováno v: Journal of rheumatology, 26(1), 60-67. Journal of Rheumatology

We related soluble Fas (sFas) levels to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) in a longitudinal series of plasma samples of patients with SLE to evaluate the relation between excessive production of sFas and disease activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::454f7c7f8fca193a352d07e0d3b0d010
https://pure.amc.nl/en/publications/patients-with-systemic-lupus-erythematosus-with-high-plasma-levels-of-sfas-risk-relapse(e4c5c40b-3811-422a-8ba1-bf52f53b8871).html

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Soluble Fas levels in sera of bone marrow transplantation recipients are increased during acute graft-versus-host disease but not during infections

Autor: Lm, Liem, van Lopik T, Annemarie van Nieuwenhuijze, Hc, Houwelingen, Aarden L, Goulmy E

Publikováno v: Blood, 91, 1464-1468
Scopus-Elsevier
Annemarie van Nieuwenhuijze
Europe PubMed Central

Graft-versus-host disease (GVHD) and infections are two major complications of allogeneic bone marrow transplantation (BMT). In the course of GVHD, one of the pathways that activated cytotoxic T cells use to execute their killing mechanisms is the Fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7c5f814ca44aa91eae7b52583c70708c
https://pubmed.ncbi.nlm.nih.gov/9454779

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Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: a phase I dose-escalating study

Autor: van Zaanen, H. C., Lokhorst, H. M., Aarden, L. A., Rensink, H. J., Warnaar, S. O., van der Lelie, J., van Oers, M. H.

Publikováno v: British journal of haematology, 102(3), 783-790. Wiley-Blackwell

Interleukin 6 plays a key role in the pathogenesis of multiple myeloma (MM). Therefore we conducted a phase I dose-escalating study with chimaeric monoclonal anti-IL6 antibodies (cMab) in MM patients resistant to second-line chemotherapy. The cMab (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::feee71a7cb2c97d7d7a763c085239f28
https://pure.amc.nl/en/publications/chimaeric-antiinterleukin-6-monoclonal-antibodies-in-the-treatment-of-advanced-multiple-myeloma-a-phase-i-doseescalating-study(4ae276b4-5459-4de1-acd6-d8d60f2a4be0).html

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