Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Aarash Bordbar"'
Autor:
Travis Nemkov, Davide Stefanoni, Aarash Bordbar, Aaron Issaian, Bernhard O. Palsson, Larry J. Dumont, Ariel Hay, Anren Song, Yang Xia, Jasmina S. Redzic, Elan Z. Eisenmesser, James C. Zimring, Steve Kleinman, Kirk C. Hansen, Michael P. Busch, Angelo D’Alessandro, the Recipient Epidemiology and Donor Evaluation Study III Red Blood Cell–Omics (REDS-III RBC-Omics) Study
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Computational models based on recent maps of the RBC proteome suggest that mature erythrocytes may harbor targets for common drugs. This prediction is relevant to RBC storage in the blood bank, in which the impact of small molecule drugs or other xen
Externí odkaz:
https://doaj.org/article/10ef3ba194d24381b742b21602b2835e
Autor:
Ali Ebrahim, Elizabeth Brunk, Justin Tan, Edward J. O'Brien, Donghyuk Kim, Richard Szubin, Joshua A. Lerman, Anna Lechner, Anand Sastry, Aarash Bordbar, Adam M. Feist, Bernhard O. Palsson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Translating omics data sets into biological insight is one of the great challenges of our time. Here, the authors make headway by synchronising pairs of omics data types via invariants across conditions and by integrating datasets into a genome-scale
Externí odkaz:
https://doaj.org/article/54b0e226f9794904895aa0e7518d169f
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 7, p e1005039 (2016)
Progress in systems medicine brings promise to addressing patient heterogeneity and individualized therapies. Recently, genome-scale models of metabolism have been shown to provide insight into the mechanistic link between drug therapies and systems-
Externí odkaz:
https://doaj.org/article/67d35b3e2b484a338948838175ecd703
Autor:
Ali Ebrahim, Eivind Almaas, Eugen Bauer, Aarash Bordbar, Anthony P Burgard, Roger L Chang, Andreas Dräger, Iman Famili, Adam M Feist, Ronan MT Fleming, Stephen S Fong, Vassily Hatzimanikatis, Markus J Herrgård, Allen Holder, Michael Hucka, Daniel Hyduke, Neema Jamshidi, Sang Yup Lee, Nicolas Le Novère, Joshua A Lerman, Nathan E Lewis, Ding Ma, Radhakrishnan Mahadevan, Costas Maranas, Harish Nagarajan, Ali Navid, Jens Nielsen, Lars K Nielsen, Juan Nogales, Alberto Noronha, Csaba Pal, Bernhard O Palsson, Jason A Papin, Kiran R Patil, Nathan D Price, Jennifer L Reed, Michael Saunders, Ryan S Senger, Nikolaus Sonnenschein, Yuekai Sun, Ines Thiele
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 10, Pp n/a-n/a (2015)
Externí odkaz:
https://doaj.org/article/889764d4207842bb8d486cb49f32b9c4
Autor:
Hojung Nam, Miguel Campodonico, Aarash Bordbar, Daniel R Hyduke, Sangwoo Kim, Daniel C Zielinski, Bernhard O Palsson
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003837 (2014)
Altered metabolism in cancer cells has been viewed as a passive response required for a malignant transformation. However, this view has changed through the recently described metabolic oncogenic factors: mutated isocitrate dehydrogenases (IDH), succ
Externí odkaz:
https://doaj.org/article/04a38c5545694958a010207816f363fe
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45635 (2012)
Biological systems are inherently hierarchal and multiscale in time and space. A major challenge of systems biology is to describe biological systems as a computational model, which can be used to derive novel hypothesis and drive experiments leading
Externí odkaz:
https://doaj.org/article/455334280c0d4405a50759e40931201f
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Metabolic coupling of Mycobacterium tuberculosis to its host is foundational to its pathogenesis. Computational genome‐scale metabolic models have shown utility in integrating ‐omic as well as physiologic data for systemic, mechanistic analysis o
Externí odkaz:
https://doaj.org/article/ee29f60a9ffd453c85e53e45a7737935
Autor:
Mark Seielstad, Adam S. Butterworth, Stacy M Endres-Dighe, Connie M. Westhoff, Aarash Bordbar, Yontao Lu, Steve Kleinman, Brian Custer, Brendan J. Keating, Carolyn Hoppe, Tamir Kanias, Yuelong Guo, Michael P. Busch, Alan E. Mast, Grier P. Page
Publikováno v:
Transfusion. 59:101-111
Background Many aspects of transfusion medicine are affected by genetics. Current single-nucleotide polymorphism (SNP) arrays are limited in the number of targets that can be interrogated and cannot detect all variation of interest. We designed a tra
Autor:
Jasmina S. Redzic, Larry J. Dumont, Angelo D'Alessandro, Travis Nemkov, Yang Xia, Kirk C. Hansen, Anren Song, Aarash Bordbar, Michael P. Busch, Recipient Epidemiology, Elan Z. Eisenmesser, James C. Zimring, Davide Stefanoni, Ariel Hay, Bernhard O. Palsson, Aaron Issaian, Steve Kleinman
Publikováno v:
JCI insight, vol 6, iss 3
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
Computational models based on recent maps of the red blood cell proteome suggest that mature erythrocytes may harbor targets for common drugs. This prediction is relevant to red blood cell storage in the blood bank, in which the impact of small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d1860d195b8c1b32de04060856a431
https://escholarship.org/uc/item/7d8467k2
https://escholarship.org/uc/item/7d8467k2
Autor:
James C. Zimring, Ariel Hay, Yang Xia, Anren Song, Donor Evaluation Study-III (Reds-Iii) RBC-Omics Study, Recipient Epidemiology, Elan Z. Eisenmesser, Bernhard O. Palsson, Aarash Bordbar, Aaron Issaian, Jasmina S. Redzic, Davide Stefanoni, Angelo D'Alessandro, Larry J. Dumont, Steve Kleinman, Travis Nemkov, Michael P. Busch, Kirk C. Hansen
Publikováno v:
SSRN Electronic Journal.
Computational models based on recent maps of the red blood cell proteome suggest that mature erythrocytes may harbor targets for common drugs. This prediction is relevant to red blood cell storage in the blood bank, in which the impact of small molec