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pro vyhledávání: '"Aapo Aho"'
Publikováno v:
Molecules, Vol 26, Iss 2, p 490 (2021)
Oligonucleotides modified by a 2′-deoxy-2′-(N-methoxyamino) ribonucleotide react readily with aldehydes in slightly acidic conditions to yield the corresponding N-(methoxy)oxazolidine-linked oligonucleotide-conjugates. The reaction is reversible
Externí odkaz:
https://doaj.org/article/7fc2ef1f381a45c79d1aafe7a0056122
Autor:
Aapo Aho, Pasi Virta
Publikováno v:
Chemical Communications. 59:5689-5692
A dynamic pH-responsive covalent ligation of split aptamer fragments utilizing a small molecule substrate as a template is described.
Publikováno v:
European Journal of Organic Chemistry. 2022
Conjugation of Oligonucleotides to Peptide Aldehydes via a pH-Responsive N-Methoxyoxazolidine Linker
Publikováno v:
Organic Letters. 22:6714-6718
The formation of N-methoxyoxazolidines in the preparation of oligonucleotide-peptide conjugates was evaluated. The reaction occurred between unprotected 2'-N-(methoxy)amino-modified oligonucleotides and peptide aldehydes in reasonable yields when iso
Publikováno v:
Organic letters. 22(17)
The formation of