Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Aaminah Khan"'
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer
Autor:
Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Marie Wong, Alvin Kamili, Maria Tsoli, Tim W Failes, Amit Kumar, Emily V A Mould, Andrew Gifford, Shu‐Oi Chow, Mark Pinese, Jamie I Fletcher, Greg M Arndt, Dong‐Anh Khuong‐Quang, Carol Wadham, Daniel Batey, Georgina Eden, Peter Trebilcock, Swapna Joshi, Stephanie Alfred, Anjana Gopalakrishnan, Aaminah Khan, Dylan Grebert Wade, Patrick A Strong, Elodie Manouvrier, Lisa T Morgan, Miriam Span, Jin Yi Lim, Roxanne Cadiz, Caitlin Ung, David M Thomas, Katherine M Tucker, Meera Warby, Geoffrey B McCowage, Luciano Dalla‐Pozza, Jennifer A Byrne, Federica Saletta, Andrew Fellowes, Stephen B Fox, Murray D Norris, Vanessa Tyrrell, Toby N Trahair, Richard B Lock, Mark J Cowley, Paul G Ekert, Michelle Haber, David S Ziegler, Glenn M Marshall
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-15 (2021)
Abstract Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. We developed a precision medicine platform of rapid high‐throughput drug screening (HTS) and patient‐
Externí odkaz:
https://doaj.org/article/f2db646d5831450d847f4d18a36cdea2
Autor:
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in
Externí odkaz:
https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8
Autor:
Anahid Ehteda, Sandy Simon, Laura Franshaw, Federico M. Giorgi, Jie Liu, Swapna Joshi, Jourdin R.C. Rouaen, Chi Nam Ignatius Pang, Ruby Pandher, Chelsea Mayoh, Yujie Tang, Aaminah Khan, Caitlin Ung, Ornella Tolhurst, Anne Kankean, Elisha Hayden, Rebecca Lehmann, Sylvie Shen, Anjana Gopalakrishnan, Peter Trebilcock, Katerina Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber, Orazio Vittorio, Maria Tsoli, David S. Ziegler
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108994- (2021)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (
Externí odkaz:
https://doaj.org/article/f3c43c1ed6e44cbd8f4c250a0e00921a
Autor:
Erin T. Kaseda, Emily E. Graupman, Samuel Vincent, Reid Faith, Meghan M. Howe, Madison Dykins, Courtney N. Beussink, Aaminah Khan, Karolina Grotkowski, Steven A. Miller
Publikováno v:
Stat. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d3c2904d30c7a7e2b8d078a4baec21
https://doi.org/10.1002/sta4.498
https://doi.org/10.1002/sta4.498
Publikováno v:
Assessment. :107319112311561
The Heterosexist Harassment, Rejection, and Discrimination Scale (HHRDS) is one of the most commonly used measures of sexual orientation-related discrimination, but little is known about its psychometric properties across different sexual orientation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeff955936a5103727aecddb61268023
https://doi.org/10.1177/10731911231156135
https://doi.org/10.1177/10731911231156135
Autor:
Jayne Murray, Laura D. Gamble, Michelle Haber, Claudia Flemming, Emanuele Valli, Denise M. T. Yu, Sophie Allan, Murray D. Norris, Aaminah Khan, Andrei L. Osterman, Georgina L. Eden, Jamie I. Fletcher, Rupinder Pandher, Kimberley M. Hanssen, Hayley Lam, David Scott
Publikováno v:
Oncogene
Amplification of the MYCN oncogene occurs in approximately 25% of primary neuroblastomas and is the single most powerful biological marker of poor prognosis in this disease. MYCN transcriptionally regulates a range of biological processes important f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c5e227162ebaf17ef04149b3000a60
https://doi.org/10.1038/s41388-020-1235-2
https://doi.org/10.1038/s41388-020-1235-2
Publikováno v:
Archives of Clinical Neuropsychology. 37:1330-1330
Objective: The Brief Assessment of Cognition in Schizophrenia (BACS) is widely used to assess cognition in schizophrenia spectrum disorders (SZ). However, norms were developed using a sample of 85% white and 15% black participants. Validation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee090f5992bd40374fe16f4c50d59d6
https://doi.org/10.1093/arclin/acac060.174
https://doi.org/10.1093/arclin/acac060.174
Autor:
Holly Holliday, Anahid Ehteda, Aaminah Khan, Brian Krug, Jourdin R C Rouaen, Nisitha Jayatilleke, Chelsea Mayoh, Orazio Vittorio, Nada Jabado, Maria Tsoli, David S Ziegler
Publikováno v:
Neuro-Oncology. 24:i18-i18
Effective treatments are urgently needed for the incurable paediatric brainstem tumour Diffuse Midline Glioma (DMG). Most DMGs contain Histone H3 mutations (H3K27M), which produce extensive epigenetic dysregulation by inhibiting EZH2-mediated trimeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd0280783f838db57bdd0aa94488e331
https://doi.org/10.1093/neuonc/noac079.063
https://doi.org/10.1093/neuonc/noac079.063
Autor:
Chelsea Mayoh, Mark R. Burns, Ruby Pandher, Anahid Ehteda, Michelle Haber, Laura D. Gamble, David S. Ziegler, Caitlin Ung, Dannielle Upton, Nada Jabado, Claudia L. Kleinman, Maria Tsoli, Steven Hébert, Denise M. T. Yu, Murray D. Norris, Aaminah Khan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977c454c52d5077ce362074ecf9bf714
https://doi.org/10.1038/s41467-021-20896-z
https://doi.org/10.1038/s41467-021-20896-z
Autor:
Swapna Joshi, Murray D. Norris, Sandy Simon, Orazio Vittorio, Sylvie Shen, Andrei V. Gudkov, Ornella Tolhurst, Anahid Ehteda, Caitlin Ung, Jourdin R. C. Rouaen, Ruby Pandher, Aaminah Khan, Michelle Haber, Elisha Hayden, Laura Franshaw, Rebecca Lehmann, Chelsea Mayoh, Yujie Tang, Katerina Gurova, David S. Ziegler, Maria Tsoli, Federico M. Giorgi, Anjana Gopalakrishnan, Jie Liu, Chi Nam Ignatius Pang, Anne Kankean, Peter Trebilcock
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108994-(2021)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbee79680e90f0fba780fc68415fa1d
https://hdl.handle.net/11585/831846
https://hdl.handle.net/11585/831846
