Zobrazeno 1 - 10
of 823
pro vyhledávání: '"Aalten, P."'
Autor:
Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103117- (2024)
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively reg
Externí odkaz:
https://doaj.org/article/174bdfaa05484649a9d4e82ff51fecbf
Autor:
Ahnjili Zhuparris, Ghobad Maleki, Liesbeth van Londen, Ingrid Koopmans, Vincent Aalten, Iris E. Yocarini, Vasileios Exadaktylos, Albert van Hemert, Adam Cohen, Pim Gal, Robert-Jan Doll, Geert Jan Groeneveld, Gabriël Jacobs, Wessel Kraaij
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Drug development for mood disorders can greatly benefit from the development of robust, reliable, and objective biomarkers. The incorporation of smartphones and wearable devices in clinical trials provide a unique opportunity to monitor beha
Externí odkaz:
https://doaj.org/article/7fc77d26e65c4a94b6761c3ca90e1519
Autor:
Florence Authier, Nina Ondruskova, Andrew T. Ferenbach, Alison D. McNeilly, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/efc22cabbb364e4299dad3bb5b55dac5
Autor:
Haibin Yu, Dandan Liu, Yaowen Zhang, Ruijun Tang, Xunan Fan, Song Mao, Lu Lv, Fang Chen, Hongtao Qin, Zhuohua Zhang, Daan MF van Aalten, Bing Yang, Kai Yuan
Publikováno v:
eLife, Vol 13 (2024)
O-GlcNAcylation is a dynamic post-translational modification that diversifies the proteome. Its dysregulation is associated with neurological disorders that impair cognitive function, and yet identification of phenotype-relevant candidate substrates
Externí odkaz:
https://doaj.org/article/6c6eefd4c2924060b89bc0e379a659a4
Autor:
Bron, Esther E., Klein, Stefan, Papma, Janne M., Jiskoot, Lize C., Venkatraghavan, Vikram, Linders, Jara, Aalten, Pauline, De Deyn, Peter Paul, Biessels, Geert Jan, Claassen, Jurgen A. H. R., Middelkoop, Huub A. M., Smits, Marion, Niessen, Wiro J., van Swieten, John C., van der Flier, Wiesje M., Ramakers, Inez H. G. B., van der Lugt, Aad
This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI).
Externí odkaz:
http://arxiv.org/abs/2012.08769
Autor:
Nicola Morrice, Susanne Vainio, Kirsi Mikkola, Lidy van Aalten, Jennifer R. Gallagher, Michael L.J. Ashford, Alison D. McNeilly, Rory J. McCrimmon, Alexandra Grosfeld, Patricia Serradas, Jukka Koffert, Ewan R. Pearson, Pirjo Nuutila, Calum Sutherland
Publikováno v:
Molecular Metabolism, Vol 77, Iss , Pp 101807- (2023)
Objectives: Metformin is the first line therapy recommended for type 2 diabetes. However, the precise mechanism of action remains unclear and up to a quarter of patients show some degree of intolerance to the drug, with a similar number showing poor
Externí odkaz:
https://doaj.org/article/60ff9417f6b94a40a6a38abc3d1becfc
Autor:
Leandro R. Soria, Georgios Makris, Alfonso M. D’Alessio, Angela De Angelis, Iolanda Boffa, Veronica M. Pravata, Véronique Rüfenacht, Sergio Attanasio, Edoardo Nusco, Paola Arena, Andrew T. Ferenbach, Debora Paris, Paola Cuomo, Andrea Motta, Matthew Nitzahn, Gerald S. Lipshutz, Ainhoa Martínez-Pizarro, Eva Richard, Lourdes R. Desviat, Johannes Häberle, Daan M. F. van Aalten, Nicola Brunetti-Pierri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Hyperammonemia occurs in liver diseases affecting ureagenesis, and is life-threatening. Here, the authors show that liver UDP-GlcNAc is increased during hyperammonemia, leading to O-GlcNAcylation of the rate-limiting ureagenesis enzyme CPS1, that enh
Externí odkaz:
https://doaj.org/article/f7dd4ac66ee843bca09996d7cef4b0de
Akademický článek
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Akademický článek
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Autor:
Michaela Omelková, Christina Dühring Fenger, Marta Murray, Trine Bjørg Hammer, Veronica M. Pravata, Sergio Galan Bartual, Ignacy Czajewski, Allan Bayat, Andrew T. Ferenbach, Marios P. Stavridis, Daan M. F. van Aalten
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/6c57373f8d2a40f7b2a046c323d0064e