Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Aakash Gautam Mukhopadhyay"'
Publikováno v:
Seminars in Cell & Developmental Biology
Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like organelles found on the surface of virtually all human cell types. By delivering proteins to the growing ciliary tip, recycling turnover products, and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81514448b32d27c12af4fa924c440d
https://doi.org/10.1016/j.semcdb.2020.05.021
https://doi.org/10.1016/j.semcdb.2020.05.021
Autor:
Anthony J. Roberts, Nicola L. Stevenson, David J. Stephens, Laura Vuolo, Aakash Gautam Mukhopadhyay
Publikováno v:
Vuolo, L, Stevenson, N L, Mukhopadhyay, A G, Roberts, A J & Stephens, D 2020, ' Cytoplasmic dynein-2 at a glance ', Journal of Cell Science . https://doi.org/10.1242/jcs.240614
Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ea5171934dc4d9a087ad27ccec1cb7
https://hdl.handle.net/1983/e3ba6905-d2dd-49cb-a5c8-a9869a918715
https://hdl.handle.net/1983/e3ba6905-d2dd-49cb-a5c8-a9869a918715
Publikováno v:
Molecular and Biochemical Parasitology. 225:27-37
Trypanosomes of the genus Leishmania swim by undulating motions of a single flagellum driven by axonemal dynein ATPases, essential for parasite survival and infectivity. The flagellum possesses two waveforms; flagellar (tip-to-base) responsible for f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e874577f0d05edc8e8c7a746454cb9b
https://doi.org/10.1016/j.molbiopara.2018.08.002
https://doi.org/10.1016/j.molbiopara.2018.08.002
Publikováno v:
Biochemical and Biophysical Research Communications. 493:1425-1429
Mitogen-activated protein kinases (MAPKs) have been demonstrated to regulate flagellar/ciliary motility of spermatozoa and miracidia of Schistosoma mansoni . However, the role of MAPKs in mediating flagella-driven motility of Leishmania donovani is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c98ff451c7fd42e3480ba4fa4161da1
https://doi.org/10.1016/j.bbrc.2017.09.135
https://doi.org/10.1016/j.bbrc.2017.09.135
Publikováno v:
Parasitology Research. 116:3221-3228
We have previously reported the involvement of cyclic AMP in regulating flagellar waveforms in Leishmania. Here, we investigated the roles of calcium, calmodulin, and calcineurin in flagellar motility regulation in L. donovani. Using high-speed video
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd8f92d80e3025a3cf64dba0ab3585c
https://doi.org/10.1007/s00436-017-5608-6
https://doi.org/10.1007/s00436-017-5608-6
Publikováno v:
Molecular and Biochemical Parasitology. 214:75-81
Axonemal dyneins are members of AAA+ proteins involved in force generation and are responsible for flagellar motility in eukaryotes. In this study, we characterized the effects of ciliobrevin A (CbA), a dynein ATPase inhibitor, on flagella driven mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f5ad07f25217235d7a0f135e1e580f
https://doi.org/10.1016/j.molbiopara.2017.04.003
https://doi.org/10.1016/j.molbiopara.2017.04.003
Autor:
Katerina Toropova, Anthony J. Roberts, Andrew P. Carter, Aakash Gautam Mukhopadhyay, Ruta Zalyte, Miroslav Mladenov
Publikováno v:
Nature structural & molecular biology
Dynein-2 assembles with polymeric intraflagellar transport (IFT) trains to form a transport machinery that is crucial for cilia biogenesis and signaling. Here we recombinantly expressed the ~1.4-MDa human dynein-2 complex and solved its cryo-EM struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce8db09939a90f3c31ff765a5018a59
https://pubmed.ncbi.nlm.nih.gov/31451806
https://pubmed.ncbi.nlm.nih.gov/31451806
Publikováno v:
Biochemistry and Biophysics Reports
Dyneins are high molecular weight microtubule based motor proteins responsible for beating of the flagellum. The flagellum is important for the viability of trypanosomes like Leishmania. However, very little is known about dynein and its role in flag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6c9453d3bd0053d14112ae07c260d1
Publikováno v:
Scientific Reports
The flagellum of parasitic trypanosomes is a multifunctional appendage essential for its viability and infectivity. However, the biological mechanisms that make the flagellum so dynamic remains unexplored. No method is available to access and induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e227ffe200670fd7b61b013837846c8