Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.

Autor: Ekaterina Posokhova, David Ng, Aaisha Opel, Ikuo Masuho, Andrew Tinker, Leslie G Biesecker, Kevin Wickman, Kirill A Martemyanov

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76973 (2013)

Normal heart function requires generation of a regular rhythm by sinoatrial pacemaker cells and the alteration of this spontaneous heart rate by the autonomic input to match physiological demand. However, the molecular mechanisms that ensure consiste

Externí odkaz: https://doaj.org/article/d8b427b5acaf46cca7dbe1378b01ae8d

Comparison of a high throughput day case atrial fibrillation ablation service in a local hospital with standard regional tertiary cardiac centre care

Autor: Aaisha Opel, Richard J. Schilling, Alison Butler, Josephine Mansell, Ross J. Hunter, Malcolm Finlay, Michael Fannon, Rhona Schwartz

Publikováno v: EP Europace. 21:440-444

AIMS We investigated safety and efficacy of a high throughput atrial fibrillation (AF) ablation service within a local non-cardiac centre compared with matched patients at the regional tertiary cardiac centre. METHODS AND RESULTS Patients were consen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f331f00d68ec5b206bf4e0d32a0a623
https://doi.org/10.1093/europace/euy153

POSTERS (1)59MULTIPOLAR CONTACT MAPPING GUIDED ABLATION OF TEMPORALLY STABLE HIGH FREQUENCY AND COMPLEX FRACTIONATED ATRIAL ELECTROGRAM SITES IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION60INTRA-CARDIAC AND PERIPHERAL LEVELS OF BIOCHEMICAL MARKERS OF FIBROSES IN PATIENTS UNDERGOING CATHETER ABLATION FOR ATRIAL FIBRILATION61THE DON'T WAIT TO ANTICOAGULATE PROJECT (DWAC) BY THE WEST OF ENGLAND ACADEMIC HEALTH SCIENCE NETWORK (AHSN) OPTIMISES STROKE PREVENTION FOR PATIENTS WITH ATRIAL FIBRILLATION (AF) WITHIN PRIMARY CARE IN LINE WITH NICE CG180 IN THE WEST OF ENGLAND62ILLNESS AND TREATMENT REPRESENTATIONS, COPING AND DISTRESS: VICIOUS CYCLES OF EVERYDAY EXPERIENCES IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION63THE NEEDS OF THE ADOLESCENT LIVING WITH AN INHERITED CARDIAC CONDITION: THE PATIENTS' PERSPECTIVE64SAFETY AND EFFICACY OF PARAMEDIC TREATMENT OF REGULAR SUPRAVENTRICULAR TACHYCARDIA (PARA-SVT)65NATURAL PROGRESSION OF QRS DURATION FOLLOWING IMPLATABLE CARDIOVERTER DEFIBRILLATORS (ICD) - IMPLANTATION66COMPARISON OF EFFICACY OF VOLTAGE DIRECTED CAVOTRICUSPID ISTHMUS ABLATION USING MINI VS CONVENTIONAL ELETRODES67CRYOBALLOON ABLATION (CRYO) FOR ATRIAL FIBRILLATION (AF) CANNOT BE GUIDED BY TEMPERATURE END-POINTS ALONE68MODERATOR BAND ECTOPY UNMASKED BY ADENOSINE AS A CAUSE OF ECTOPIC TRIGGERED IDIOPATHIC VF69EARLY CLINICAL EXPERIENCE WITH TARGETED SITE SELECTION FOR THE WiCS-LV ELECTRODE FOR CRT70DOES VECTOR MAPPING PRIOR TO IMPLANTABLE LOOP RECORDER INSERTION IMPROVE THE DETECTION OF ARRHYTHMIA?71THE ROLE OF SPECKLE TRACKING STRAIN IMAGING IN ASSESSING LEFT VENTRICULAR RESPONSE TO CARDIAC RESYNCHRONISATION THERAPY IN RESPONDERS AND NON-RESPONDERS72EVALUATING PATIENTS' EXPERIENCE AND SATISFACTION OF THE ATRIAL FIBRILLATION ABLATION PROCEDURE: A RETROSPECTIVE ANALYSIS73TROUBLESHOOTING LV LEAD IMPLANTATION - NOVEL 'UNIRAIL TECHNIQUE'74SUBCLINICAL ATHEROSCELEROSIS AND COGNITIVE IMPAIRMENT75EFFECT OF LOZARTANE ON DEVELOPMENT OF THE ELECTRICAL INSTABILITY OF THE MYOCARDIUM76THE INTERPLAY BETWEEN BODY COMPOSITION AND LEFT VENTRICULAR REMODELLING IN CARDIAC RESYNCHRONISATION THERAPY77FAMILY SCREENING IN IDIOPATHIC VENTRICULAR FIBRILLATION78MANAGEMENT OF ATRIAL FIBRILLATION IN A LARGE TEACHING HOSPITAL79THE EFFECT OF LEFT VENTRICULAR LEAD POSITION ON SURVIVAL IN PATIENTS WITH BINVENTRICULAR PACEMAKRS/DEFIBRILLATORS80ACUTE DEVICE IMPLANT-RELATED COMPLICATIONS DO NOT INCREASE LATE MORTALITY81ABORTED CARIDAC ARREST AS THE SENTINEL PRESENTATION IN A COHORT OF PATIENTS WITH THE CONCEALED BRUGADA PHENOTYPE82POST-CARDIAC DEVICE IMPLANTATION MOBILISATION ADVICE: A NATIONAL SURVEY83DO RISK SCORES DEVELOPED TO PROTECT ONE-YEAR MORTALITY ACTUALLY HELP IN ACCURATELY SELECTING PATIENTS RECEIVING PRIMARY PREVENTION ICD?84ATRIAL TACHYCARDIA ARISING FROM THE NON-CORONARY AORTIC CUSP85THE EFFECT OF DIFFERENT ATRIAL FIBRILLATION ABLATION STRATEGIES ON SURFACE ECG P WAVE DURATION86PRESCRIBING DRONEDARONE: HOW IS IT DONE ACROSS THE UK AND IS IT SAFE?87A CASE OF WIDE COMPLEX TACHYCARDIA88TRANSITION TO DEDICATED DAY CASE DEVICES - SAFETY AND EFFICACY IN A LARGE VOLUME CENTRE89SEQUENTIAL REGIONAL DOMINANT FREQUENCY MAPPING DURING ATRIAL FIBRILLATION: A NOVEL TEQUNIQUE90ELECTIVE CARDIOVERSION ENERGY PROTOCOLS: A RETROSPECTIVE COMPARISON OF ESCALATION STRATEGIES91THE INCIDENCE OF CLINCALLY RELEVANT HAEMATOMAS WITH PERIOPERATIVE USE OF NEWER P2Y12 INHIBITORS AND INTERRUPTED NOAC THERAPY IN CARDIAC IMPLANTABLE ELECTRONIC DEVICE INSERTION92AN AUDIT OF THE OUTCOMES FOR CHEMICAL AND DIRECT CURRENT CARDIOVERSION FOR ATRIAL FIBRILLATION AT OUR DGH OVER A 3 YEAR DURATION93REAL LIFE ACUTE MANAGEMET OF HAEMODYNAMICALLY TOLERATED MONOMORPHIC VENTRICULAR TACHYCARDIA. ARE WE MAKING EVIDENCE BASED ON DECISIONS?94A SERVICE EVALUATION TO ASSESS THE EFFICACY AND SAFETY OF NOVEL ORAL ANTICOAGULANTS VERSUS WARFARIN FOR ELECTIVE CARDIVERSION IN PATIENTS WITH NON VALVULAR AF IN A NURSE LED CARDIOVERSION SERVICE95PICK UP RATE OF IMPLANTED LOOP RECORDER AT A DISTRICT HOSPITAL

Autor: K. Nizam ud Din, T.E. Edwards, R.J. Taylor, A.S. Sadiq, A.Y. Yeoh, A.S. Moss, Hassan Shariat, S.V. Saravu Vijayashankar, E. Yones, G.O. Furniss, A. Merghani, S.A. Akbar, G. Collins, Bode Ensam, K. Al-Lawati, M. Shah, S. Honarbakhsh, C.J. McAloon, N.V. Getman, Sevara Tairova, A.A. Khokhar, D. Thomas, K. Prakash, D.E. Thomas, A. Opel, Aaisha Opel, D.P. Redfearn, Wern Yew Ding, Shohreh Honarbakhsh, R.T. Buck, E.C. Taylor, J. Moore, G.A. Begg, D.T. Raine, P. Langley, E.J. Shepherd, S. Murray, S.W. Lord, J.P. Bourke, S. Plein, G.Y. Lip, M. H. Tayebjee, N. Owen, S. White, M. O'Neill, L.D. Hughes, S. Carroll, R. Moss-Morris, V. Baker, C. Kirkby, K. Patel, G. Robinson, S. Antoniou, L. Richmond, W. Ullah, R.J. Hunter, M. Finlay, M.J. Earley, M. Whitbread, R.J. Schilling, R. Cooper, S. Modi, R. Somani, A. Ng, N. Hobson, J.C. Caldwell, S. Hadjivassilev, R. Ang, M. Dhinoja, M. Earley, S. Sporton, R. Schilling, R. Hunter, P. Lambiase, A.J. Turley, N.M. Child, N.J. Linker, W.A. Owens, S.A. James, J. Milner, M. Tayebjee, J. Sibley, A. Griffiths, T. Meredith, Y. Basher, T.R. Betts, K. Rajappan, P.D. Lambiase, M.D. Lowe, Gulnara Rakhimbaeva, Nigora Akramova, T.V. Getman, T. Hamborg, J.P. O'Hare, H. Randeva, F. Osman, N. Srinivasan, E. Firman, L. Tobin, C. Murphy, M. Lowe, P. Mohan, G. Salahia, H.S. Lim, HS Lim, Velislav Batchvarov, Paul Brennan, Andrew Cox, Alison Muir, Elijah Behr, S. Hamill, C. Laventure, S. Newell, B. Gordon, K. Bashir, J. Chuen, W. Foster, S. Yusuf, S. Hayat, D. Panagopoulos, E.J. Davies, D.R. Tomlinson, G.A. Haywood, J. Mullan, N. Kelland, A. Horwood, N. Connell, S. Odams, J. Maloney, A. Shetty, A. Kyriacou, J. Sahu, J. Lee, O.U. Uzun, A.W. Wong, S.A. Ashtekar, Javad Hashemi, Saeed Gazor, Damian Redfearn, A. Song, J. Jenkins, J. Glancy, D.W. Wilson, E.S. Sammut, I.D. Diab, T.R.C. Cripps, A.G. Gill, S.A. Abbas, J.U. Enye, A.W. Wahab, S.E. Elshafie, K.L. Ling, P.C. Carey, D.C. Chatterjee, S.T. Timbrell, W.T. Tufail, H.W. Why, R.M. Martos, A.R. Thornley, S. James, M.G.D. Bates, E.H. Hassan, J.Q. Quick, R.P.W. Cowell, E. Ho

Publikováno v: Europace. 18:ii24-ii35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::589db54aa6af1fb9230eb04c213fb460
https://doi.org/10.1093/europace/euw273

Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling

Autor: Malcolm Finlay, Aaisha Opel, Ross A. Breckenridge, Andrew Tinker, David Montaigne, Naomi Anderson, Muriel Nobles

Publikováno v: Journal of Biological Chemistry. 290:19233-19244

The description of potential molecular substrates for predisposition to atrial fibrillation (AF) is incomplete, and it is unknown what role regulators of G-protein signaling might play. We address whether the attenuation of RGS4 function may promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6c574a8490aefc3513ac3e92b26bc2
https://doi.org/10.1074/jbc.m115.666719

iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death

Autor: Mario Notari, Aaisha Opel, Arash Yavari, Kieran Clarke, Gopinath Sutendra, Min Lu, Laurent Dupays, Sofia V. de Noronha, Mike Hollinshead, Timothy J. Mohun, Zinaida Dedeic, Mary N. Sheppard, Xin Lu, Shan Zhong, David J. P. Ferguson, Hugh Watkins, Andrew Tinker, Ying Hu, Carolyn A. Carr, David P. Kelsell

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 112(9)

Desmosomes are anchoring junctions that exist in cells that endure physical stress such as cardiac myocytes. The importance of desmosomes in maintaining the homeostasis of the myocardium is underscored by frequent mutations of desmosome components fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f79813f2fa0b3110bb4d87d6e3970ae
https://pubmed.ncbi.nlm.nih.gov/25691752