Výsledky vyhledávání - "AYAKO HIROTA"

Akademický článek

Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines.

Autor: Kazuhiro Hirasawa, Shota Moriya, Kana Miyahara, Hiromi Kazama, Ayako Hirota, Jun Takemura, Akihisa Abe, Masato Inazu, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0164529 (2016)

Autophagy, a self-digestive system for cytoplasmic components, is required to maintain the amino acid pool for cellular homeostasis. We previously reported that the macrolide antibiotics azithromycin (AZM) and clarithromycin (CAM) have an inhibitory

Externí odkaz: https://doaj.org/article/b41545854e87476c9c986f8449422fe2

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Akademický článek

A Case of Scrofuloderma in a Patient on JAK Inhibitor Treatment for Rheumatoid Arthritis.

Autor: Tomomichi SHIMIZU, Ayako HIROTA, Nobuhiro TAKAHASHI, Aya OKANIWA, Reiko SAITO, Narumi SAITO, Akio KONDOH, Fumikazu YAMAZAKI, Susumu TOSHIMA, Tomotaka MABUCHI

Publikováno v: Tokai Journal of Experimental & Clinical Medicine; Sep2024, Vol. 49 Issue 3, p101-104, 4p

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Lysosome‑targeted drug combination induces multiple organelle dysfunctions and non‑canonical death in pancreatic cancer cells

Autor: Sumire Suzuki, Masato Ogawa, Masaya Miyazaki, Kohki Ota, Hiromi Kazama, Ayako Hirota, Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa

Publikováno v: Oncology Reports

Pancreatic cancer is one of the leading causes of cancer-related mortality and has the lowest 5-year survival rate. Therefore, novel strategies are urgently required to treat pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) cells rely on en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efa094bcfa254be188acc592e6cd2d
https://pubmed.ncbi.nlm.nih.gov/34958115

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Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines

Autor: Hiroko Kokuba, Jun Takemura, Takashi Ishikawa, Kazuhiro Hirasawa, Keisuke Miyazawa, Masaki Hiramoto, Hiromi Kazama, Akihisa Abe, Shota Moriya, Ayako Hirota, Seiichiro Komatsu, Kana Miyahara

Publikováno v: International Journal of Oncology

The ubiquitin-proteasome and autophagy-lysosome pathways are two major self-digestive systems for cellular proteins. Ubiquitinated misfolded proteins are degraded mostly by proteasome. However, when ubiquitinated proteins accumulate beyond the capaci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6388e26de2c6adf3a737f4e746aeb04d
http://europepmc.org/articles/PMC5063435

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Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells

Autor: Shota Moriya, Kaho Yamasaki, Akihiko Gotoh, Yusuke Kawai, Masaki Hiramoto, Keisuke Miyazawa, Seiichiro Komatsu, Masato Inazu, Ayako Hirota, Xiao-Fang Che, Hiroko Kokuba

Publikováno v: International Journal of Oncology

The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b7337ac5f461c088d79e60d93cad6c
http://europepmc.org/articles/PMC4277245

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Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice

Autor: Kazuhiko Hamada, Fujio Otsuka, Yasuhiro Kawachi, Ayako Hirota, Tsutomu Koga, Masayuki Yamamoto

Publikováno v: Experimental Dermatology. 20:664-668

Ultraviolet (UV) radiation is one of the most important environmental factors involved in the pathogenesis of premature skin ageing, termed photoageing. The harmful effects of UV in photoageing are associated with the generation of reactive oxygen sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::482ca557e04dc5335d816dec3ee19de8
https://doi.org/10.1111/j.1600-0625.2011.01292.x

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Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines

Autor: Jun Takemura, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa, Hiromi Kazama, Shota Moriya, Kazuhiro Hirasawa, Ayako Hirota, Masato Inazu, Akihisa Abe, Kana Miyahara

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0164529 (2016)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a988af238e227456b5e0146228fe3f
http://europepmc.org/articles/PMC5158196?pdf=render

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Ultraviolet A Irradiation Induces NF-E2-Related Factor 2 Activation in Dermal Fibroblasts: Protective Role in UVA-Induced Apoptosis

Autor: Yasuhiro Kawachi, Masayuki Yamamoto, Xuezhu Xu, Takenori Takahashi, Yasuhiro Nakamura, Ayako Hirota, Tomohiro Banno, Fujio Otsuka, Ken Itoh

Publikováno v: Journal of Investigative Dermatology. 124:825-832

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Ultraviolet (UV) radiation is one of the most important environmental factors involved in the pathogenesis of skin aging and cancer. Many harmful effects of UV radiation are associated with the generation of reactive oxygen speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a239f5d195bbb9f676cadfe5fb306b
https://doi.org/10.1111/j.0022-202x.2005.23670.x

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Yin-Yang 1 Negatively Regulates the Differentiation-Specific Transcription of Mouse Loricrin Gene in Undifferentiated Keratinocytes

Autor: Yasuhiro Nakamura, Dennis R. Roop, Xuezhu Xu, Takenori Takahashi, Yasuhiro Kawachi, Fujio Otsuka, Hideko Sakurai, Ayako Hirota, Tomohiro Banno

Publikováno v: Journal of Investigative Dermatology. 123(6):1120-1126

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Loricrin is a major component of the epidermal cornified cell envelope, and is expressed only in terminally differentiated keratinocytes. This cell differentiation-specific expression pattern suggests specific suppression of lori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6440ccbc55ee56530016f2c98f1fa3e3

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Autor: Chiaki Kobayashi, Michiyo Ohyashiki, Ayako Hirota, Junko H. Ohyashiki, Kazuma Ohyashiki

Publikováno v: Immunity & Ageing, Vol 8, Iss 1, p 11 (2011)
Immunity & Ageing : I & A

MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any association between these levels and agei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7e857ca3a8b3d585ecf65d6417159f
http://www.immunityageing.com/content/8/1/11

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