Výsledky vyhledávání

Akademický článek

New improved radiometabolite analysis method for [18F]FTHA from human plasma: a test-retest study with postprandial and fasting state

Autor: Richard Aarnio, Anna Kirjavainen, Johan Rajander, Sarita Forsback, Kari Kalliokoski, Pirjo Nuutila, Zvonko Milicevic, Tamer Coskun, Axel Haupt, Iina Laitinen, Merja Haaparanta-Solin

Publikováno v: EJNMMI Research, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Background Fatty acid uptake can be measured using PET and 14-(R,S)‐[18F]fluoro‐6‐thia‐heptadecanoic acid ([18F]FTHA). However, the relatively rapid rate of [18F]FTHA metabolism significantly affects kinetic modeling of tissue uptake

Externí odkaz: https://doaj.org/article/431ec5815c0a4c829a4b8d52c133bc9b

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

Autor: Tamer Coskun, Kyle W. Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Krister B. Bokvist, Xuewei Cui, Daniel A. Briere, Over Cabrera, William C. Roell, Uma Kuchibhotla, Julie S. Moyers, Charles T. Benson, Ruth E. Gimeno, David A. D'Alessio, Axel Haupt

Publikováno v: Molecular Metabolism, Vol 18, Iss , Pp 3-14 (2018)

Objective: A novel dual GIP and GLP-1 receptor agonist, LY3298176, was developed to determine whether the metabolic action of GIP adds to the established clinical benefits of selective GLP-1 receptor agonists in type 2 diabetes mellitus (T2DM). Metho

Externí odkaz: https://doaj.org/article/e80aeca8145a4ac5b361969b75b1dc5e

Zobrazit plný text záznamu

Akademický článek

An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans

Autor: Otto Tschritter, Axel Haupt, Hubert Preissl, Caroline Ketterer, Anita M. Hennige, Tina Sartorius, Fausto Machicao, Andreas Fritsche, Hans-Ulrich Häring

Publikováno v: Journal of Obesity, Vol 2011 (2011)

Activation of melanocortin-4 receptor (MC4R) by insulin sensitive neurons is a central mechanism in body weight regulation, and genetic variants in the MC4R gene (e.g., rs17782313) are associated with obesity. By using magnetoencephalography, we addr

Externí odkaz: https://doaj.org/article/635e9e9d8e80417d8ff3464ef2b7ac1d

Zobrazit plný text záznamu

Once-Weekly Basal Insulin Fc Demonstrated Similar Glycemic Control to Once-Daily Insulin Degludec in Insulin-Naive Patients With Type 2 Diabetes: A Phase 2 Randomized Control Trial

Autor: Juliana M. Bue-Valleskey, Christof M. Kazda, Chenchen Ma, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Axel Haupt, Juan P. Frias

Publikováno v: Diabetes Care. 46:1060-1067

OBJECTIVE Basal insulin Fc (BIF) (insulin efsitora alfa; LY3209590), a fusion protein combining a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-weekly basal insulin administration. This phase 2 study assessed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::554f271b1679eb8ceb0cb386d844a4f3
https://doi.org/10.2337/dc22-2396

Zobrazit plný text záznamu

Novel Once-Weekly Basal Insulin Fc Achieved Similar Glycemic Control With a Safety Profile Comparable to Insulin Degludec in Patients With Type 1 Diabetes

Autor: Christof M. Kazda, Juliana M. Bue-Valleskey, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Paula Wullenweber, Axel Haupt, Dominik Dahl

Publikováno v: Diabetes Care. 46:1052-1059

OBJECTIVE Basal Insulin Fc (BIF; insulin efsitora alfa; LY3209590), a fusion protein combining a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-weekly basal insulin administration. This phase 2 study assessed safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b09912fe9e31ff8d441e60a36156d404
https://doi.org/10.2337/dc22-2395

Zobrazit plný text záznamu

Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes

Autor: Tim Heise, J. Hans DeVries, Shweta Urva, Jing Li, Edward J. Pratt, Melissa K. Thomas, Kieren J. Mather, Chrisanthi A. Karanikas, Julia Dunn, Axel Haupt, Zvonko Milicevic, Tamer Coskun

Publikováno v: Diabetes Care. 46:998-1004

OBJECTIVE To evaluate the effects of tirzepatide on body composition, appetite, and energy intake to address the potential mechanisms involved in body weight loss with tirzepatide. RESEARCH DESIGN AND METHODS In a secondary analysis of a randomized,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48517387ad5d00f605bd3c125d750b3d
https://doi.org/10.2337/dc22-1710

Zobrazit plný text záznamu

LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial

Autor: Shweta, Urva, Tamer, Coskun, Mei Teng, Loh, Yu, Du, Melissa K, Thomas, Sirel, Gurbuz, Axel, Haupt, Charles T, Benson, Martha, Hernandez-Illas, David A, D'Alessio, Zvonko, Milicevic

Publikováno v: The Lancet. 400:1869-1881

Treating hyperglycaemia and obesity in individuals with type 2 diabetes using multi-receptor agonists can improve short-term and long-term outcomes. LY3437943 is a single peptide with agonist activity for glucagon, glucose-dependent insulinotropic po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6fbf9575e306306e92cc4c2bbb96b7
https://doi.org/10.1016/s0140-6736(22)02033-5

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání