P03.03 Active immunization against human endogenous retrovirus type K (HERV-K) as an immunotherapeutic strategy against solid tumors

Autor: E Ragonnaud, L Neukirch, IS Pedersen, J Daradoumis, KV Grunddal, L Duvnjak, AV Bermejo, S Schroedel, C Thirion, KN Nielsen, AC Andersson, PJ Holst

Publikováno v: Poster Presentations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::750d521590c54c1d8439b5017097410f
https://doi.org/10.1136/jitc-2022-itoc9.31

An Endogenous Retrovirus Vaccine Encoding an Envelope with a Mutated Immunosuppressive Domain in Combination with Anti-PD1 Treatment Eradicates Established Tumours in Mice.

Autor: Daradoumis J; Department of Immunology and Microbiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark., Ragonnaud E; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark.; Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Skandorff I; Department of Immunology and Microbiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark., Nielsen KN; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark., Bermejo AV; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark.; Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Andersson AM; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark., Schroedel S; Sirion Biotech GmbH, 82166 Graefelfing, Germany., Thirion C; Sirion Biotech GmbH, 82166 Graefelfing, Germany., Neukirch L; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark.; Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Holst PJ; Department of Immunology and Microbiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.; InProTher, Bioinnovation Institute, COBIS, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark.

Publikováno v: Viruses [Viruses] 2023 Apr 06; Vol. 15 (4). Date of Electronic Publication: 2023 Apr 06.

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.

Autor: Møller SH; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Mellergaard M; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Madsen M; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Bermejo AV; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Jepsen SD; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Hansen MH; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Høgh RI; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Aldana BI; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Desler C; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Rasmussen LJ; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Sustarsic EG; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Gerhart-Hines Z; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Daskalaki E; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Wheelock CE; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Hiron TK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Lin D; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., O'Callaghan CA; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Wandall HH; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Andresen L; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark., Skov S; Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Aug 11; Vol. 11, pp. 1968. Date of Electronic Publication: 2020 Aug 11 (Print Publication: 2020).