Výsledky vyhledávání - "ATSUSHI KITANI"

Akademický článek

Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function

Autor: Liming Mao, Atika Dhar, Guangxun Meng, Ivan Fuss, Kim Montgomery-Recht, Zhiqiong Yang, Qiuyun Xu, Atsushi Kitani, Warren Strober

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The studies described here provide an analysis of the pathogenesis of Blau syndrome and thereby the function of NOD2 as seen through the lens of its dysfunction resulting from Blau-associated NOD2 mutations in its nucleotide-binding domain (NBD). As

Externí odkaz: https://doaj.org/article/5b47c420c24a4ec0821c1dbd820857bd

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Akademický článek

The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease

Autor: Liming Mao, Atsushi Kitani, Warren Strober, Ivan J. Fuss

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

It is logical to assume that a major pro-inflammatory mechanism, i.e., the NLRP3 inflammasome would play a prominent role in the pathogenesis of the Inflammatory Bowel Disease (IBD) in humans. However, while both studies of murine models of gut disea

Externí odkaz: https://doaj.org/article/f0158f84b244426cb3a91e9d8c4a92ee

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Akademický článek

NOD1-Mediated Mucosal Host Defense against Helicobacter pylori

Autor: Tomohiro Watanabe, Naoki Asano, Atsushi Kitani, Ivan J. Fuss, Tsutomu Chiba, Warren Strober

Publikováno v: International Journal of Inflammation, Vol 2010 (2010)

Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 response

Externí odkaz: https://doaj.org/article/67373bb686f64cce816a765b0963cfe8

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Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis

Autor: Atsushi Kitani, Liming Mao, Kim Montgomery-Recht, Wenchang Zhou, Adrian Wiestner, Ivan J. Fuss, Eitaro Hiejima, Warren Strober

Publikováno v: J Clin Invest

Bruton tyrosine kinase (BTK) is present in a wide variety of cells and may thus have important non–B cell functions. Here, we explored the function of this kinase in macrophages with studies of its regulation of the NLR family, pyrin domain–conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5065c11282ca001a45a6d2d7dd148c30
https://doi.org/10.1172/jci128322

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RICK/RIP2 is a NOD2-independent nodal point of gut inflammation

Autor: Tomoyuki Nagai, Kosuke Minaga, Ivan J. Fuss, Masatoshi Kudo, Ken Kamata, Atsushi Kitani, Masaki Tajima, Toshiharu Sakurai, Warren Strober, Yoriaki Komeda, Tomohiro Watanabe

Publikováno v: Int Immunol

Previous studies have shown that inhibition of receptor-interacting serine/threonine kinase (RICK) (also known as RIP2) results in amelioration of experimental colitis. This role has largely been attributed to nucleotide-binding oligomerization domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85f350da3fb05fd2c3ea9ed6939e84d
https://doi.org/10.1093/intimm/dxz045

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Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease

Autor: Martha Quezado, Lindsey Albenberg, Michael Yao, Atiye Aktay, Kim Montgomery-Recht, Liming Mao, Atsushi Kitani, Andrew J. Oler, Judith R. Kelsen, Ivan J. Fuss, Warren Strober, Morgan Similuk

Publikováno v: Journal of Clinical Investigation. 128:1793-1806

In these studies, we evaluated the contribution of the NLRP3 inflammasome to Crohn's disease (CD) in a kindred containing individuals having a missense mutation in CARD8, a protein known to inhibit this inflammasome. Whole exome sequencing and PCR st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad5f272d9f0fa4b73b2ed148da1b3ce
https://doi.org/10.1172/jci98642

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Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities

Autor: Masako Mizuno-Kamiya, Tatsuo Ichinohe, Eiji Takayama, Harumi Kawaki, Takahiro Nakata, Warren Strober, Shin Ichi Tokuno, Tsukasa Shigehiro, Akifumi Mizutani, Yasuko Honjo, Junko Masuda, Ayano Satoh, Ivan J. Fuss, Naoki Umemura, Toshiaki Ishizuka, Masaharu Seno, Yuji Morimoto, Nobuo Kondoh, Atsushi Kitani

Publikováno v: Oncology Reports. 38:449-455

To evaluate systemic immunity associated with tumor growth limited to a subcutaneous site versus growth proceeding at multiple tumor sites, we established syngeneic mouse subcutaneous and pulmonary tumor models by local subcutaneous and intravenous i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9edd554c40501af73b30bc1cfd3636
https://doi.org/10.3892/or.2017.5646

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Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting

Autor: Hiroshi Kawamoto, Ayano Satoh, Yoshimoto Katsura, Vaidyanath Arun, Akifumi Mizutani, Warren Strober, Tomokatsu Ikawa, Tomonari Kasai, Ivan J. Fuss, Hiroshi Murakami, Tsukasa Shigehiro, Junko Masuda, Narumi Maeno, Masaharu Seno, Akimasa Seno, Atsushi Kitani, Eiji Takayama

Publikováno v: Applied Biochemistry and Biotechnology. 180:1559-1573

Transplantation of hematopoietic stem and progenitor cells (HSCs) i.e., self-renewing cells that retain multipotentiality, is now a widely performed therapy for many hematopoietic diseases. However, these cells are present in low number and are subje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ed1383ac9ec83eac9fc4f66b2989d5
https://doi.org/10.1007/s12010-016-2187-4

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